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61.
Role of long extracellular channels in fluid transport across epithelia 总被引:13,自引:0,他引:13
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Hummingbirds are among the smallest endothermic vertebrates. Because they forage by energetically costly hovering, and because weight-specific basal metabolic rates increase with decreasing body size, their basal and active metabolic rates are among the highest recorded. Hummingbirds fuel these metabolic requirements mainly with highly concentrated sugar in nectar, which they extract rapidly and efficiently by an unknown mechanism. It is especially puzzling that, despite their high energy requirements, hummingbirds spend only approximately 20% of their waking hours feeding, but 75% perched and apparently doing nothing. Here we report the first measurement of nutrient absorption by hummingbird intestine and present a new method for measuring crop-emptying times. We find that hummingbird intestine has the highest active glucose transport rate and lowest passive glucose permeability reported for any vertebrate. Crop-emptying time may limit feeding-bout frequency and could largely account for the time spent perched. 相似文献
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Daffis S Szretter KJ Schriewer J Li J Youn S Errett J Lin TY Schneller S Zust R Dong H Thiel V Sen GC Fensterl V Klimstra WB Pierson TC Buller RM Gale M Shi PY Diamond MS 《Nature》2010,468(7322):452-456
Cellular messenger RNA (mRNA) of higher eukaryotes and many viral RNAs are methylated at the N-7 and 2'-O positions of the 5' guanosine cap by specific nuclear and cytoplasmic methyltransferases (MTases), respectively. Whereas N-7 methylation is essential for RNA translation and stability, the function of 2'-O methylation has remained uncertain since its discovery 35 years ago. Here we show that a West Nile virus (WNV) mutant (E218A) that lacks 2'-O MTase activity was attenuated in wild-type primary cells and mice but was pathogenic in the absence of type I interferon (IFN) signalling. 2'-O methylation of viral RNA did not affect IFN induction in WNV-infected fibroblasts but instead modulated the antiviral effects of IFN-induced proteins with tetratricopeptide repeats (IFIT), which are interferon-stimulated genes (ISGs) implicated in regulation of protein translation. Poxvirus and coronavirus mutants that lacked 2'-O MTase activity similarly showed enhanced sensitivity to the antiviral actions of IFN and, specifically, IFIT proteins. Our results demonstrate that the 2'-O methylation of the 5' cap of viral RNA functions to subvert innate host antiviral responses through escape of IFIT-mediated suppression, and suggest an evolutionary explanation for 2'-O methylation of cellular mRNA: to distinguish self from non-self RNA. Differential methylation of cytoplasmic RNA probably serves as an example for pattern recognition and restriction of propagation of foreign viral RNA in host cells. 相似文献
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Evolved stars of about one solar mass are in general spherically symmetric, yet the planetary nebulae that they produce in the next phase of their evolution tend not to exhibit such symmetry. Collimated 'jets' and outflows of material have been observed up to approximately 0.3 parsec from the central stars of planetary nebulae, and precession of those jets has been proposed to explain the observed asymmetries. Moreover, it has recently been shown theoretically that magnetic fields could launch and collimate such jets. Here we report the detection of a collimated and precessing jet of molecular gas that is traced by water-vapour maser spots approximately 500 astronomical units (au) from the star W43A in Aquila. We conclude that the jet is formed in the immediate vicinity of the star, and infer that elongated planetary nebulae are formed by jets during the short period, of less than 1,000 years, when the star makes its transition through the proto-planetary nebula phase to become a planetary nebula. 相似文献
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