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41.
M. N. Gillespie L. Diamond J. Newburger H. B. Kostenbauder 《Cellular and molecular life sciences : CMLS》1977,33(7):936-938
Summary The quaternary ammonium compound, methantheline, was found to antagonize acetylcholine induced contractions in isolated guinea pig ileum by a mechanism which did not conform to the criteria for either competitive or non-competitive inhibition. Enhancement of the lipid solubility of methantheline by formation of an ion pair with trichloracetate failed to influence its cholinergic inhibitory activity. The results suggest that in the guinea pig ileum a) an intracellular site of action does not exist for methantheline and b) the membrane receptors for methantheline most likely are located in an aqueous environment. 相似文献
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43.
Protein synthesis by amoebal ribosomes 总被引:2,自引:0,他引:2
44.
J M Diamond 《Nature》1987,327(6123):552-553
45.
The quaternary ammonium compound, methantheline, was found to antagonize acetylcholine induced contractions in isolated guinea pig ileum by a mechanism which did not conform to the criteria for either competitive or non-competitive inhibition. Enhancement of the lipid solubility of methantheline by formation of an ion pair with trichloracetate failed to influence its cholinergic inhibitory activity. The results suggest that in the guinea pig ileum a) an intracellular site of action does not exist for methantheline and b) the membrane receptors for methantheline most likely are located in an aqueous environment. 相似文献
46.
What maintains the frequencies of human genetic diseases? 总被引:2,自引:0,他引:2
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48.
de Bakker PI Burtt NP Graham RR Guiducci C Yelensky R Drake JA Bersaglieri T Penney KL Butler J Young S Onofrio RC Lyon HN Stram DO Haiman CA Freedman ML Zhu X Cooper R Groop L Kolonel LN Henderson BE Daly MJ Hirschhorn JN Altshuler D 《Nature genetics》2006,38(11):1298-1303
A general question for linkage disequilibrium-based association studies is how power to detect an association is compromised when tag SNPs are chosen from data in one population sample and then deployed in another sample. Specifically, it is important to know how well tags picked from the HapMap DNA samples capture the variation in other samples. To address this, we collected dense data uniformly across the four HapMap population samples and eleven other population samples. We picked tag SNPs using genotype data we collected in the HapMap samples and then evaluated the effective coverage of these tags in comparison to the entire set of common variants observed in the other samples. We simulated case-control association studies in the non-HapMap samples under a disease model of modest risk, and we observed little loss in power. These results demonstrate that the HapMap DNA samples can be used to select tags for genome-wide association studies in many samples around the world. 相似文献
49.
Sotoodehnia N Isaacs A de Bakker PI Dörr M Newton-Cheh C Nolte IM van der Harst P Müller M Eijgelsheim M Alonso A Hicks AA Padmanabhan S Hayward C Smith AV Polasek O Giovannone S Fu J Magnani JW Marciante KD Pfeufer A Gharib SA Teumer A Li M Bis JC Rivadeneira F Aspelund T Köttgen A Johnson T Rice K Sie MP Wang YA Klopp N Fuchsberger C Wild SH Mateo Leach I Estrada K Völker U Wright AF Asselbergs FW Qu J Chakravarti A Sinner MF Kors JA Petersmann A Harris TB Soliman EZ Munroe PB Psaty BM 《Nature genetics》2010,42(12):1068-1076
50.