有机二氟化磷双核铜(Ⅰ)配合物的合成和表征

合成了三个新型的有机二氟化磷双核铜(Ⅰ)配合物[Cu_2Cl_2(2.5-Me_2PhPF_2)_2]、[Cu_2Cl_2(Ne_2NPF_2)_2]和[Cu_2Cl_2(F_2POCH_2CH_2OPF_2)_2]。通过元素分析、分子量测定、红外光谱和~(31)P-NMR光谱对这些配合物进行了表征。研究发现,在这些配合物的结构中,Cl~(-1)桥联两个Cu(Ⅰ)使其具有桥式结构,配体中的两个P原子分别与两个Cu(Ⅰ),P—Cu(Ⅰ)反馈π键的强度随着和P相联原子的电负性的增大而增强。     

四川石棉大水沟碲矿床的同位素地质研究

石棉大水沟相矿是世界首例独立的破多金属矿床。矿体严格产于变质岩中，成矿作用在时间上与赋矿围岩经受的区域动热变质作用相一致。成矿输液的６Ｄ值为一６８．７％－一４１．６％，８＇勺值为２·６１‰～１１．９３‰，它最可能来源于变质水，是赋矿围岩在区域动热变质过程中发生的脱挥发反应形成的。Ｐｈ，Ｓｒ，Ｓ，Ｃ同位素研究表明，成矿物质具多来源特点，成矿组分是在区域动热变质的有利条件下，通过变质热液对围岩的浸取而它集成矿。     

多复变数Bergman空间中的Hardy—Littlewood定理

在C^n中有界对称域上的Bergman空间中建立了Hardy-Littlewood定理，并用更一般的分数次导数Dβf(β≥0）替代了单复变中的通常导数f′。最后还将这一结果推广到更一般的解析函数空间中。     

植物叶绿体色素的纸色谱分离

报道了一种新的以石油醚—氯仿—异两醇(79:20:1)三元体系为展开剂,分离叶绿体色素的单向纸色谱法,能够完全分离高等植物中常见的六种叶绿体色素,叶绿素a、叶绿素b、β-胡萝卜素、叶黄素、紫黄质、新黄质和一种叶绿素a的衍生物脱植基叶绿素a。     

铁氧体多层结构电波吸收体的研究

用三种不同磁导率μｉ的铁氧体基复合电波吸收材料制成双层结构电波吸收体,在７～１２ＧＨｚ频段Ａ～ｆ曲线与单层基本相似,存在两个吸收峰,但第二峰移向高频,吸收量Ａ由２０ｄＢ增至３７ｄＢ;在吸收介质层与反射板之间以及在两个介质层之间涂以介电型介质膜,使第一吸收峰移向高频,吸收量分别增至２９ｄＢ和２７ｄＢ;对其作用机理进行探讨。     

节水洗衣机的最优运行模型

在不考虑时间、温度情况下,我们讨论了洗衣机用水量与洗涤次数的关系,得出了解析式,并给出了总用水量最小值的每次加水量一定条件下成立的定理,并据解析式,列出了数据表格、讨论给出了最佳节水洗涤方案,分析了实验数据Ｕ、ＶｇＱ对结果影响,在推广中讨论了Ｖｇ的其它确定方式及自动控制洗涤次数的方案。     

中性载体DAM推动Ca^2＋离子在水／硝基苯界面的转移

本文用卷积(半微分和半积分)循环伏安法研究了中性载体DAM(二安替比林甲烷)络合推动Ca~(2 )离子在水/硝基苯界面的转移过程,探讨了有关转移过程的机理,测定了相应的扩散系数和配合物的络合稳定常数。     

Plectonema boryanum作为外源质粒受体的筛选及其原生质球的制备与再生

对三种丝状蓝藻株系（ＰｈｏｒｍｉｄｉｕｍＬｕｒｉｄｕｍ，Ｐｈｏｒｍｉｄｉｕｍｆａｖｅｏｌａｒｕｍ和Ｐｌｅｃｔｏｎｅｍａｂｏ－ｒｙａｍｕｍ）的研究结果表明：Ｐ，ｂｏｒｙａｎｕｍ因无明显限制性内切核酸酶活性可作为受体进一步研究，对其原生质球的释出和新细胞再生的最适条件分析表明：０．１％溶菌酶作用的最适时间为２ｈ温度为３５℃，ｐＨ为７．０～７．５（０．８ｍｏｌ／Ｌ的甘露醇为最适渗透稳定剂）。这些条件适合于在ＢＧ－１１液体中释放原生质球及固体培养基上新细胞的再生。     

Rab5 is a signalling GTPase involved in actin remodelling by receptor tyrosine kinases

Rab5 is a small GTPase involved in the control of intracellular trafficking, both at the level of receptor endocytosis and endosomal dynamics. The finding that Rab5 can be activated by receptor tyrosine kinases (RTK) raised the question of whether it also participates in effector pathways emanating from these receptors. Here we show that Rab5 is indispensable for a form of RTK-induced actin remodelling, called circular ruffling. Three independent signals, originating from Rab5, phosphatidylinositol-3-OH kinase and Rac, respectively, are simultaneously required for the induction of circular ruffles. Rab5 signals to the actin cytoskeleton through RN-tre, a previously identified Rab5-specific GTPase-activating protein (GAP). Here we demonstrate that RN-tre has the dual function of Rab5-GAP and Rab5 effector. We also show that RN-tre is critical for macropinocytosis, a process previously connected to the formation of circular ruffles. Finally, RN-tre interacts with both F-actin and actinin-4, an F-actin bundling protein. We propose that RN-tre establishes a three-pronged connection with Rab5, F-actin and actinin-4. This may aid crosslinking of actin fibres into actin networks at the plasma membrane. Thus, we have shown that Rab5 is a signalling GTPase and have elucidated the major molecular elements of its downstream pathway.     

Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene

The FBXW7/hCDC4 gene encodes a ubiquitin ligase implicated in the control of chromosome stability. Here we identify the mouse Fbxw7 gene as a p53-dependent tumour suppressor gene by using a mammalian genetic screen for p53-dependent genes involved in tumorigenesis. Radiation-induced lymphomas from p53+/- mice, but not those from p53-/- mice, show frequent loss of heterozygosity and a 10% mutation rate of the Fbxw7 gene. Fbxw7+/- mice have greater susceptibility to radiation-induced tumorigenesis, but most tumours retain and express the wild-type allele, indicating that Fbxw7 is a haploinsufficient tumour suppressor gene. Loss of Fbxw7 alters the spectrum of tumours that develop in p53 deficient mice to include a range of tumours in epithelial tissues such as the lung, liver and ovary. Mouse embryo fibroblasts from Fbxw7-deficient mice, or wild-type mouse cells expressing Fbxw7 small interfering RNA, have higher levels of Aurora-A kinase, c-Jun and Notch4, but not of cyclin E. We propose that p53-dependent loss of Fbxw7 leads to genetic instability by mechanisms that might involve the activation of Aurora-A, providing a rationale for the early occurrence of these mutations in human cancers.