A genome-wide association study in Han Chinese identifies new susceptibility loci for ankylosing spondylitis

To identify susceptibility loci for ankylosing spondylitis, we performed a two-stage genome-wide association study in Han Chinese. In the discovery stage, we analyzed 1,356,350 autosomal SNPs in 1,837 individuals with ankylosing spondylitis and 4,231 controls; in the validation stage, we analyzed 30 suggestive SNPs in an additional 2,100 affected individuals and 3,496 controls. We identified two new susceptibility loci between EDIL3 and HAPLN1 at 5q14.3 (rs4552569; P = 8.77 × 10(-10)) and within ANO6 at 12q12 (rs17095830; P = 1.63 × 10(-8)). We also confirmed previously reported associations in Europeans within the major histocompatibility complex (MHC) region (top SNP, rs13202464; P < 5 × 10(-324)) and at 2p15 (rs10865331; P = 1.98 × 10(-8)). We show that rs13202464 within the MHC region mainly represents the risk effect of HLA-B*27 variants (including HLA-B*2704, HLA-B*2705 and HLA-B*2715) in Chinese. The two newly discovered loci implicate genes related to bone formation and cartilage development, suggesting their potential involvement in the etiology of ankylosing spondylitis.     

Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder

Transitional cell carcinoma (TCC) is the most common type of bladder cancer. Here we sequenced the exomes of nine individuals with TCC and screened all the somatically mutated genes in a prevalence set of 88 additional individuals with TCC with different tumor stages and grades. In our study, we discovered a variety of genes previously unknown to be mutated in TCC. Notably, we identified genetic aberrations of the chromatin remodeling genes (UTX, MLL-MLL3, CREBBP-EP300, NCOR1, ARID1A and CHD6) in 59% of our 97 subjects with TCC. Of these genes, we showed UTX to be altered substantially more frequently in tumors of low stages and grades, highlighting its potential role in the classification and diagnosis of bladder cancer. Our results provide an overview of the genetic basis of TCC and suggest that aberration of chromatin regulation might be a hallmark of bladder cancer.     

A20 (TNFAIP3) deficiency in myeloid cells triggers erosive polyarthritis resembling rheumatoid arthritis

A20 (TNFAIP3) is a protein that is involved in the negative feedback regulation of NF-κB signaling in response to specific proinflammatory stimuli in different cell types and has been suggested as a susceptibility gene for rheumatoid arthritis. To define the contribution of A20 to rheumatoid arthritis pathology, we generated myeloid-specific A20-deficient mice and show that specific ablation of Tnfaip3 in myeloid cells results in spontaneous development of a severe destructive polyarthritis with many features of rheumatoid arthritis. Myeloid-A20-deficient mice have high levels of inflammatory cytokines in their serum, consistent with a sustained NF-κB activation and higher TNF production by macrophages. Destructive polyarthritis in myeloid A20 knockout mice was TLR4-MyD88 and IL-6 dependent but was TNF independent. Myeloid A20 deficiency also promoted osteoclastogenesis in mice. Together, these observations indicate a critical and cell-specific function for A20 in the etiology of rheumatoid arthritis, supporting the idea of developing A20 modulatory drugs as cell-targeted therapies.     

Fault-Tolerant Design for Data Efficient Retransmission in WiNoC

There is a sharp decline in the network performance when the wireless link fails as a data path in the Wireless Network-on-Chip(WiNoC).To counteract this problem,we propose a fault-tolerance mechanism for the efficient retransmission of data in the WiNoC.When an error is detected in the data transmission process,this mechanism works to feed back the fault information to the source node in real time via fault signal lines.In the source node,the highest transmission priority is assigned to the backup retransmitted data,and the corresponding direct link is positioned to enable the data packet for its efficient retransmission to the destination node,thereby ensuring efficiency in fault tolerance.Additionally,we have improved the receiving port of the wireless router,added the corresponding redundant buffers and mux,and dynamically selected the retransmitted non-faulty data packets to be written to the local router in order to avoid the disorderly retransmission of the data packets.The evaluation results of this paper demonstrate that compared with the methods which are under different fault conditions,this fault-tolerant method drastically improves the data throughput rate,reduces the delay,effectively guarantees the reliability of the network,and improves the system performance.     

TiC对原位自生钛基复合材料高温变形的影响

通过等温热压模拟试验研究了原位自生5% TiC(体积分数,下同)颗粒增强Ti-1100复合材料在1000~1150℃的热变形行为.在不同的温度区间内计算了原位自生5%TiC/Ti-1100复合材料的塑性变形激活能.结果发现,TiC颗粒对钛基材料的热变形行为有明显影响.复合材料的塑性变形激活能在不同的温度区间内变化.在1000℃,复合材料的表观塑性变形激活能为536 kJ/mol,显著高于纯钛合金的激活能;在1150℃,计算出的复合材料表观塑性变形激活能为245.2 kJ/mol,略大于纯钛合金的激活能.变形激活能的显著差别显示复合材料的变形机制发生了变化.在此温度区间内,TiC/Ti复合材料的变形机制受到TiC颗粒以及基体中α/β相比例的影响.     

秀丽线虫sod-3基因RNA干扰及早衰模型的建立

利用RNAi技术, 通过干扰秀丽线虫中的sod-3基因表达, 建立了因超氧化物歧化酶3（SOD3）表达缺失引起快速衰老的线虫模型,为sod-3 基因功能的研究以及相关疾病的基因治疗等提供动物模型.     

民族地区高校服务地方“三融合”ICT人才培养研究与实践——一西昌学院为例

提出了“‘三融合’ICT应用型人才培养”教改模式,阐述了该模式的背景、凉山民族地区高校信息与通信技术（ICT）人才培养存在的问题,以西昌学院为例, 介绍了“‘三融合’ICT应用型人才培养模式”的实践路径, 即通过专业融合、产教融合、两育融合,从培养方案、课程体系、教学方法、评价方式、实践教学、“双师”队伍、职业精神和中华民族共同体意识这8个方面进行实践,形成凉山民族地区高校服务地方的“三融合”ICT应用型人才培养新路径。分析了该模式在凉山民族地区人才培养、产业发展、脱贫奔康和乡村振兴中所取得的积极实践成果。     

固液流化床中不同粒径粒子群的滑流速度

在稳定的流动状态下,实验考察了铅直管内粒径不同的两组分粒子群的滑流速度,并与每一组分单独存在时的值进行了对比.相对于单组分时的滑流速度,两组分场合的每一组分的滑流速度都会发生偏离并相互接近,偏离的程度受两个粒子群的粒径比、浓度比以及总粒子浓度的影响.通过对两个粒子群之间的相互影响因素的定量分析,以单成分的空隙方程式为基础,建立了在多种操作条件下直接计算滑流速度的模型.     

纳滤-反渗透技术用于高盐废水中NaCl的回收

为了实现高盐废水中NaCl的回收,采用纳滤-反渗透双膜串级组合工艺,处理NaCl和Na2 SO4的混合模拟废水,考察了浓度配比、操作压力、流速及温度等工艺参数对膜分离效果的影响,并确定出了最佳工艺参数.实验结果表明:在最佳工艺参数下,经纳滤和反渗透分离后的反渗透浓缩液中,[NaCl]/[Na2SO4]≥41.45,可实...     

乘方权重不等式的证明及其系列推论

给出了乘方权重不等式的一种证明方法,并由此得到一系列重要推论.该系列推论在证明不等式及求极限过程中有着广泛的应用.