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201.
在德国联邦研发项目UNICARagil中,开发了一个ECU,作为UNICARagil新颖的大脑架构的一部分。应用所谓的脑干部件,通过面向服务的架构,对全自动驾驶车辆进行安全关键的实时控制。本文介绍了该设备的硬件架构和基本软件架构,并列举了一些安全措施。重点是MPSoC和OS配置、ECU的更新过程和启动过程。回退实例系统可以保护它免受引导加载程序、内核或根文件系统以及开发过程中和应用现场中的严重错误的影响。最后,列举了设备在车辆环境中的功能。在众多的科学内容出版物和社交媒体上,笔者展示了以使用脑干为核心部件的车辆通过试验场的测试情况。 相似文献
202.
Khor CC Chau TN Pang J Davila S Long HT Ong RT Dunstan SJ Wills B Farrar J Van Tram T Gan TT Binh NT Tri le T Lien le B Tuan NM Tham NT Lanh MN Nguyet NM Hieu NT Van N Vinh Chau N Thuy TT Tan DE Sakuntabhai A Teo YY Hibberd ML Simmons CP 《Nature genetics》2011,43(11):1139-1141
Hypovolemic shock (dengue shock syndrome (DSS)) is the most common life-threatening complication of dengue. We conducted a genome-wide association study of 2,008 pediatric cases treated for DSS and 2,018 controls from Vietnam. Replication of the most significantly associated markers was carried out in an independent Vietnamese sample of 1,737 cases and 2,934 controls. SNPs at two loci showed genome-wide significant association with DSS. We identified a susceptibility locus at MICB (major histocompatibility complex (MHC) class I polypeptide-related sequence B), which was within the broad MHC region on chromosome 6 but outside the class I and class II HLA loci (rs3132468, P(meta) = 4.41 × 10(-11), per-allele odds ratio (OR) = 1.34 (95% confidence interval: 1.23-1.46)). We identified associated variants within PLCE1 (phospholipase C, epsilon 1) on chromosome 10 (rs3765524, P(meta) = 3.08 × 10(-10), per-allele OR = 0.80 (95% confidence interval: 0.75-0.86)). We identify two loci associated with susceptibility to DSS in people with dengue, suggesting possible mechanisms for this severe complication of dengue. 相似文献
203.
Khor CC Davila S Breunis WB Lee YC Shimizu C Wright VJ Yeung RS Tan DE Sim KS Wang JJ Wong TY Pang J Mitchell P Cimaz R Dahdah N Cheung YF Huang GY Yang W Park IS Lee JK Wu JY Levin M Burns JC Burgner D Kuijpers TW Hibberd ML;Hong Kong–Shanghai Kawasaki Disease Genetics Consortium;Korean Kawasaki Disease Genetics Consortium;Taiwan Kawasaki Disease Genetics Consortium;International Kawasaki Disease Genetics Consortium;US Kawasaki Disease Genetics Consortium;Blue Mountains Eye Study 《Nature genetics》2011,43(12):1241-1246
Kawasaki disease is a systemic vasculitis of unknown etiology, with clinical observations suggesting a substantial genetic contribution to disease susceptibility. We conducted a genome-wide association study and replication analysis in 2,173 individuals with Kawasaki disease and 9,383 controls from five independent sample collections. Two loci exceeded the formal threshold for genome-wide significance. The first locus is a functional polymorphism in the IgG receptor gene FCGR2A (encoding an H131R substitution) (rs1801274; P = 7.35 × 10(-11), odds ratio (OR) = 1.32), with the A allele (coding for histadine) conferring elevated disease risk. The second locus is at 19q13, (P = 2.51 × 10(-9), OR = 1.42 for the rs2233152 SNP near MIA and RAB4B; P = 1.68 × 10(-12), OR = 1.52 for rs28493229 in ITPKC), which confirms previous findings(1). The involvement of the FCGR2A locus may have implications for understanding immune activation in Kawasaki disease pathogenesis and the mechanism of response to intravenous immunoglobulin, the only proven therapy for this disease. 相似文献
204.
The butterflies of the Great Basin exhibit general patterns of distribution and speciation similar to those found for other taxa, particularly birds. Two major centers of infraspecific differentiation and coinciding distribution limits of taxa are identified, each with three subregions. Great Basin butterflies are characterized by pallidity and substantial endemism below the species level. 相似文献
205.
Systems engineering research 总被引:3,自引:2,他引:1
Abd-El-Kader SAHRAOUI~ Dennis M.BUEDE~ Andrew P.SAGE~ LAAS-CNRS Universitéde Toulouse Avenue du Colonel Roche Toulouse France Innovative Decisions Inc. Golf Course Dr.Reston VA USA Dept.of Systems Engineering Operations Research George Mason University Fairfax VA USA 《系统科学与系统工程学报(英文版)》2008,17(3):319-333
In this paper, we propose selected research topics that are believed central to progress and growth in the application of systems engineering (SE). As a professional activity, and as an intellectual activity, systems engineering has strong links to such associated disciplines as decision analysis, operation research, project management, quality management, and systems design. When focussing on systems engineering research, we should distinguish between subjects that are of systems engineering essence and others that more closely correspond to those that are more relevant for related disciplines. 相似文献
206.
Dennis R. Dean 《Annals of science》2013,70(6):501-521
Though among the most famous earthquakes in modern times, San Francisco (18 April 1906) has almost always been presented as nothing more than a great human disaster. While certainly that, we should regard it also as having had unusual significance in the development of seismology. Because the full extent of the San Andreas fault was thereafter recognized, and the association between faulting and earthquakes confirmed, we may consider the San Francisco earthquake of 1906 to be the first in which modern understanding of seismic causality prevailed. 相似文献
207.
Bradfield JP Taal HR Timpson NJ Scherag A Lecoeur C Warrington NM Hypponen E Holst C Valcarcel B Thiering E Salem RM Schumacher FR Cousminer DL Sleiman PM Zhao J Berkowitz RI Vimaleswaran KS Jarick I Pennell CE Evans DM St Pourcain B Berry DJ Mook-Kanamori DO Hofman A Rivadeneira F Uitterlinden AG van Duijn CM van der Valk RJ de Jongste JC Postma DS Boomsma DI Gauderman WJ Hassanein MT Lindgren CM Mägi R Boreham CA Neville CE Moreno LA Elliott P Pouta A Hartikainen AL Li M Raitakari O 《Nature genetics》2012,44(5):526-531
Multiple genetic variants have been associated with adult obesity and a few with severe obesity in childhood; however, less progress has been made in establishing genetic influences on common early-onset obesity. We performed a North American, Australian and European collaborative meta-analysis of 14 studies consisting of 5,530 cases (≥95th percentile of body mass index (BMI)) and 8,318 controls (<50th percentile of BMI) of European ancestry. Taking forward the eight newly discovered signals yielding association with P < 5 × 10(-6) in nine independent data sets (2,818 cases and 4,083 controls), we observed two loci that yielded genome-wide significant combined P values near OLFM4 at 13q14 (rs9568856; P = 1.82 × 10(-9); odds ratio (OR) = 1.22) and within HOXB5 at 17q21 (rs9299; P = 3.54 × 10(-9); OR = 1.14). Both loci continued to show association when two extreme childhood obesity cohorts were included (2,214 cases and 2,674 controls). These two loci also yielded directionally consistent associations in a previous meta-analysis of adult BMI(1). 相似文献
208.
209.
Hydrogen is an energy source for hydrothermal vent symbioses 总被引:1,自引:0,他引:1
Petersen JM Zielinski FU Pape T Seifert R Moraru C Amann R Hourdez S Girguis PR Wankel SD Barbe V Pelletier E Fink D Borowski C Bach W Dubilier N 《Nature》2011,476(7359):176-180
The discovery of deep-sea hydrothermal vents in 1977 revolutionized our understanding of the energy sources that fuel primary productivity on Earth. Hydrothermal vent ecosystems are dominated by animals that live in symbiosis with chemosynthetic bacteria. So far, only two energy sources have been shown to power chemosynthetic symbioses: reduced sulphur compounds and methane. Using metagenome sequencing, single-gene fluorescence in situ hybridization, immunohistochemistry, shipboard incubations and in situ mass spectrometry, we show here that the symbionts of the hydrothermal vent mussel Bathymodiolus from the Mid-Atlantic Ridge use hydrogen to power primary production. In addition, we show that the symbionts of Bathymodiolus mussels from Pacific vents have hupL, the key gene for hydrogen oxidation. Furthermore, the symbionts of other vent animals such as the tubeworm Riftia pachyptila and the shrimp Rimicaris exoculata also have hupL. We propose that the ability to use hydrogen as an energy source is widespread in hydrothermal vent symbioses, particularly at sites where hydrogen is abundant. 相似文献
210.