“三生空间”视角下乌鲁木齐市土地利用转型及生态环境效应分析

为探究如何优化乌鲁木齐市城镇化快速发展的资源配置方式,实现城市在“三生空间”视角下的可持续发展,本研究基于乌鲁木齐市1980—2020年（每10年一期,共5期）土地覆盖遥感影像数据,通过土地利用转移矩阵、生态环境质量指数、土地利用转型生态贡献率和InVEST模型估算生境质量等方法,定量分析了乌鲁木齐市土地利用功能转型及生态环境效应。结果表明：(1)乌鲁木齐市生态空间被持续压缩,生活空间持续增加,而生产空间则经历了先增加后减少的倒“V”型变化趋势。(2)乌鲁木齐市土地利用功能转型主要表现为草地生态空间与生产、生活空间之间的相互转化。(3)乌鲁木齐市生态环境质量指数持续下降,草地转变为其他生态空间是使乌鲁木齐市生态环境质量恶化的主要原因。(4)乌鲁木齐市的生境质量水平持续下降,草地、水域生态空间转化为其他生态空间是生境质量下降的主要原因。可见：土地利用转型会对生态环境质量产生巨大影响,研究结果可为乌鲁木齐市生态持续改善提供保障,同时还能为协调新疆土地资源的可持续利用和生态环境保护提供借鉴。     

嵌入式系统中USB Host功能的开发

采用自下向上的设计流程,在没有嵌入式操作系统支持的条件下,自主设计和实现了嵌入式USB Host功能．以ISP1362驱动USB海量存储类设备为例,描述了嵌入式USB Host系统的框架结构和底层驱动的设计方法．实验结果表明,遵从海量存储类子协议的USB设备,都能够被系统驱动,而且数据传输速度优于PC机驱动方式．     

基于GIS、GPS、GSM的救护车智能管理系统研究

文章提出了一种救护车智能管理系统。该系统基于GIS、GPS、GSM技术,它能在发生紧急事故时,提供救护车到达出事地点,再从出事地点到达最近医院的最佳路径,该系统能够使救护车始终处于监控之下。我们通过设计有效的数据结构和算法来实现系统的上述功能。     

An efficient algorithm to generate candidates in discovering frequent episodes

0 IntroductionData mining is widely used in many research fieldssuch as decision supporting systems[1], bio-informationanalysis[2]and knowledge engineering[3-5]. Most data col-lected from scientific experiments or telecommunicationnetworks have inherent sequential nature inthemand canthus be abstractly viewed as a sequence of events . Onebasic problemin miningsuchevent sequencesis discoveryof recurrent combinations of events , which are calledepisodes. Once frequent episodes are discovered,rul…     

基于烟花算法的基站群协作计算卸载模型研究

车联网、AR、AI等计算密集、时延敏感型应用迅速发展,而移动设备因自身计算能力相对不足,执行此类应用任务时会因高时延而严重影响用户体验甚至无法满足用户需求。针对此问题,提出综合考虑时延与成本的多用户、多MEC (mobile edge computing)服务器的基站群协作计算卸载模型。并提出基于凸优化的改进烟花算法（improved fireworks algorithm based on convex optimization, CVX-FWA）来对模型进行求解,对用户任务进行合理的卸载与资源分配。仿真结果表明,提出的计算卸载方案有效降低了任务总时延成本值,实现计算卸载资源的整体优化配置。     

发动机支架安装凸台的断裂故障诊断分析

针对发动机发电机支架安装凸台及连接螺栓常出现的断裂失效问题,提出一种仿真分析与实验结合的诊断方法.首先建立了包含发电机和空压机模型的支架有限元模型,并进行了约束模态分析,进而针对缸体局部和电机支架进行了螺栓预紧应力分析.最后,对发电机和空压机进行了动平衡测试.仿真与试验结果表明:发动机运行期间,连接区域松脱可能是造成失效的重要原因.采用该诊断方法解决了失效问题.     

Blockage of the NLRP3 inflammasome by MCC950 improves anti-tumor immune responses in head and neck squamous cell carcinoma

The NLRP3 inflammasome is a critical innate immune pathway responsible for producing active interleukin (IL)-1β, which is associated with tumor development and immunity. However, the mechanisms regulating the inflammatory microenvironment, tumorigenesis and tumor immunity are unclear. Herein, we show that the NLRP3 inflammasome was over-expressed in human HNSCC tissues and that the IL-1β concentration was increased in the peripheral blood of HNSCC patients. Additionally, elevated NLRP3 inflammasome levels were detected in tumor tissues of Tgfbr1/Pten 2cKO HNSCC mice, and elevated IL-1β levels were detected in the peripheral blood serum, spleen, draining lymph nodes and tumor tissues. Blocking NLRP3 inflammasome activation using MCC950 remarkably reduced IL-1β production in an HNSCC mouse model and reduced the numbers of myeloid-derived suppressor cells (MDSCs), regulatory T cells (Tregs) and tumor-associated macrophages (TAMs). Moreover, inhibiting NLRP3 inflammasome activation increased the numbers of CD4⁺ and CD8⁺ T cells in HNSCC mice. Notably, the numbers of exhausted PD-1⁺ and Tim3⁺ T cells were significantly reduced. A human HNSCC tissue microarray showed that NLRP3 inflammasome expression was correlated with the expression of CD8 and CD4, the Treg marker Foxp3, the MDSC markers CD11b and CD33, and the TAM markers CD68 and CD163, PD-1 and Tim3. Overall, our results demonstrate that the NLRP3 inflammasome/IL-1β pathway promotes tumorigenesis in HNSCC and inactivation of this pathway delays tumor growth, accompanied by decreased immunosuppressive cell accumulation and an increased number of effector T cells. Thus, inhibition of the tumor microenvironment through the NLRP3 inflammasome/IL-1β pathway may provide a novel approach for HNSCC therapy.     

灵敏度分析在惯导平台误差参数辨识中的应用

为了解决传统的惯导平台测漂方案下,惯导平台上陀螺安装误差角的系统级辨识精度不高的问题,对平台漂移的非线性模型进行了灵敏度分析,找出了影响陀螺安装误差角辨识精度的主要因素,进而提出了转台相对地面存在角速率条件下的改进辨识方案.仿真结果表明,在改进的辨识方案下误差角的辨识精度获得了显著提高.     

基于重复博弈的集群企业间社会关系构建分析

针对我国外生模式及混合内生模式集群中核心企业与依附企业间的主从支配关系,将核心企业与依附企业间的社会关系收益进行量化,讨论了核心企业与依附企业间的社会关系构建及维持的影响因素及内在机制.研究表明,核心企业与依附企业间的社会关系构建与维持取决于核心企业对双方社会关系价值的预期以及依附企业的市场价格;核心企业依据依附企业的市场价格来分割双方的社会关系收益;而依附企业可以通过提高自身的价值,获取更高的社会关系收益分割值,缔结和维持有利于自身和集群成长的社会关系.     

A partial robust optimization approach to inventory management for the offline-to-online problem under different selling prices

This study examines an optimal inventory strategy when a retailer markets a product at different selling prices through a dual-channel supply chain, comprising an online channel and an offline channel. Using the operating pattern of the offline-to-online (O2O) business model, we develop a partial robust optimization (PRO) model. Then, we provide a closed-form solution when only the mean and standard deviation of the online channel demand distribution is known and the offline channel demand follows a uniform distribution (partial robust). Specifically, owing to the good structural properties of the solution, we obtain a heuristic ordering formula for the general distribution case (i.e., the offline channel demand follows a general distribution). In addition, a series of numerical experiments prove the rationality of our conjecture. Moreover, after comparing our solution with other possible policies, we conclude that the PRO approach improves the performance of incorporating the internet into an existing supply chain and, thus, is able to adjust the level of conservativeness of the solution. Finally, in a degenerated situation, we compare our PRO approach with a combination of information approach. The results show that the PRO approach has more “robust” performance. As a result, a reasonable trade-off between robustness and performance is achieved.