Mécanisme d'action du chloramphénicol dans l'inhibition de la production d'anticorps induite par de différents types d'antigènes

Summary Chloramphenicol (CAF) administered to rabbits during the whole period of immunization, is able to suppress almost completely the antibody response against horse serum albumin and globulins (HSA, HSG) andEscherichia coli: on the other hand, it does not inhibit antibody response to heterologous RBC. The possible mechanism of the inhibiting action of the CAF in antibody response to HSA, HSG andE. coli is discussed, and some hypotheses are put forward on the possible reasons for the different behaviour of CAF on the immune response induced by heterologous RBC.     

Alteration in the SAT-chromosome ofAllium cepa affecting the size of the nucleolus

Resumen Se describe el hallazgo de un bulbo deAllium cepa en el cual los dos nucleolos de cada nÚcleo muestran una clara diferencia de tamaño. El nucleolo menor posee aproximadamente la mitad del diámetro del nucleolo normal. Esta alteración de la morfología nucleolar se correlaciona con la ausencia de satélite en uno de los dos cromosomas normalmente satelizados.

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The work reported in this paper was undertaken during the tenure of a Research Training Fellowship awarded by the International Agency for Research on Cancer.