Failure of familial Alzheimer's disease to segregate with the A4-amyloid gene in several European families

The gene coding for the amyloid protein, a component of neuritic plaques found in brain tissue from patients with Alzheimer's disease, has been localized to chromosome 21, and neighbouring polymorphic DNA markers segregate with Alzheimer's disease in several large families. These data, and the association of Alzheimer's disease with Down's syndrome, suggest that overproduction of the amyloid protein, or production of an abnormal variant of the protein, may be the underlying pathological change causing Alzheimer's disease. We have identified a restriction fragment length polymorphism of the A4-amyloid gene, and find recombinants in two Alzheimer's disease families between Alzheimer's disease and the A4-amyloid locus. This demonstrates that the gene for plaque core A4-amyloid cannot be the locus of a defect causing Alzheimer's disease in these families. These data indicate that alterations in the plaque core amyloid gene cannot explain the molecular pathology for all cases of Alzheimer's disease.     

基于透明转发器的卫星通信抗干扰技术及仿真系统

首先分析了透明转发器特点，研究了其在各种限幅条件下的抗干扰性能，然后全面分析了基于透明转发器的各种抗干扰技术，研究了各种抗干扰技术的特点及抗干扰能力，最后，提出了用于透明转发器抗干扰研究的仿真系统总体结构，并给出了其抗干扰性能评估方法。为透明转发器抗干扰研究提供了技术基础并指明 了方向，对商业卫星通信系统用于军事通信具有参考价值。     

管道网络拓扑模型与分析计算

为了解决化工过程仿真中管道网络计算的问题,本文运用邻接矩阵描述化工流程中管道网络拓扑结构,通过分析网络中串、并、分、汇4种基本拓扑特征来识别管网,得出流量压力计算的自动建模与求解算法.利用该算法,只需输入管道网络的邻接矩阵,即可自动产生流量压力分布计算的数学模型并进行实时动态求解.并成功将它们应用于实践中,效果良好.     

多目标遗传算法在甲醇合成优化中的应用

针对甲醇合成优化中的多个目标函数 ,对多目标遗传算法进行了改进 ,引进了多个体交叉算子和种群间的变异算子 ,使用多目标权重因子解决了适应度函数的构造问题 ,不仅提高了算法本身的运行速度 ,而且在处理实际的多目标优化时 ,提供了较好的灵活度 ,在指导实际生产中表现出了良好的性能。     

唐菖蒲花芽形态分化与叶片生长的关系

经观察，唐菖蒲花芽分化为向顶式，花芽形态分化可分为11个时期。花芽分化时期与叶片生长表现出较稳定的并行生长关系，并在开花球茎范围内受球茎大小的影响。     

淮北市的螺类

报道了淮北市螺类共17种,其中淡水螺类15种,陆生螺类2种,分别隶属于腹足纲的6科、10属,有3种为安徽省首次记录.作者还阐述了17种螺类的生态分布、区域分布及优势种等情况.并根据淮北市的特点,对它们的开发与利用进行了初步探讨.     

Cu2+对日本沼虾幼虾的急性致毒研究

Cu2+浓度为0.000 5 mg/L、0.005 mg/L、0.05 mg/L时,日本沼虾幼体在54 h内均能够正常存活;Cu2+浓度为0.1 mg/L时,只有部分沼虾幼体中毒致死.而当Cu2+浓度超过0.25 mg/L时,日本沼虾幼虾在48 h内致死,并出现鳃变兰、肝脏变黑的现象.随着Cu2+浓度增大,日本沼虾幼虾存活的时间变短,肝脏和鳃的中毒颜色变深.日本沼虾幼虾48 h的半致死浓度为0.268 mg/L,其安全浓度为0.026 8 mg/L.     

一个考虑土体流变的修正剑桥粘弹塑性模型

在修正剑桥模型的基础上，考虑土的流变性，提出一种可较全面地反映土体变形的各种粘弹塑性特征的修正剑桥粘弹塑性模型。进而运用该模型对室内三轴固结排水剪流变试验进行三维有限元模拟，并通过与其他模型的对比分析，初步证明了本构模型的合理性和有效性。     

The peripheral myelin protein gene PMP-22 is contained within the Charcot-Marie-Tooth disease type 1A duplication.

Charcot-Marie-Tooth disease (CMT1) is the most common form of inherited peripheral neuropathy. Although the disease is genetically heterogeneous, it has been demonstrated that the gene defect is the most frequent type (CMT1A) is the result of a partial duplication of band 17p11.2. Recent studies suggested that the peripheral hypomyelination syndrome in the trembler (Tr) mouse, a possible animal model for CMT1 disease, is associated with a point mutation in the peripheral myelin protein-22 gene (pmp-22). Expression of pmp-22 is particularly high in Schwann cells, and the protein is found in peripheral myelin. We now report that the human PMP-22 gene is contained within the CMT1A duplication. We therefore, suggest that increased dosage of the PMP-22 gene may be the cause of CMT1A neuropathy.