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91.
People or animals caught in quicksand find it very hard to escape. Here we show that quicksand acts as a trap because it becomes unstable when it is forced to move--first it liquefies, and then it collapses. But a simple sinking test demonstrates that it is impossible for a human to be drawn into quicksand altogether. 相似文献
92.
Brevetoxicosis: red tides and marine mammal mortalities 总被引:2,自引:0,他引:2
Flewelling LJ Naar JP Abbott JP Baden DG Barros NB Bossart GD Bottein MY Hammond DG Haubold EM Heil CA Henry MS Jacocks HM Leighfield TA Pierce RH Pitchford TD Rommel SA Scott PS Steidinger KA Truby EW Van Dolah FM Landsberg JH 《Nature》2005,435(7043):755-756
Potent marine neurotoxins known as brevetoxins are produced by the 'red tide' dinoflagellate Karenia brevis. They kill large numbers of fish and cause illness in humans who ingest toxic filter-feeding shellfish or inhale toxic aerosols. The toxins are also suspected of having been involved in events in which many manatees and dolphins died, but this has usually not been verified owing to limited confirmation of toxin exposure, unexplained intoxication mechanisms and complicating pathologies. Here we show that fish and seagrass can accumulate high concentrations of brevetoxins and that these have acted as toxin vectors during recent deaths of dolphins and manatees, respectively. Our results challenge claims that the deleterious effects of a brevetoxin on fish (ichthyotoxicity) preclude its accumulation in live fish, and they reveal a new vector mechanism for brevetoxin spread through food webs that poses a threat to upper trophic levels. 相似文献
93.
Martinez Molina D Wetterholm A Kohl A McCarthy AA Niegowski D Ohlson E Hammarberg T Eshaghi S Haeggström JZ Nordlund P 《Nature》2007,448(7153):613-616
Cysteinyl leukotrienes are key mediators in inflammation and have an important role in acute and chronic inflammatory diseases of the cardiovascular and respiratory systems, in particular bronchial asthma. In the biosynthesis of cysteinyl leukotrienes, conversion of arachidonic acid forms the unstable epoxide leukotriene A4 (LTA4). This intermediate is conjugated with glutathione (GSH) to produce leukotriene C4 (LTC4) in a reaction catalysed by LTC4 synthase: this reaction is the key step in cysteinyl leukotriene formation. Here we present the crystal structure of the human LTC4 synthase in its apo and GSH-complexed forms to 2.00 and 2.15 A resolution, respectively. The structure reveals a homotrimer, where each monomer is composed of four transmembrane segments. The structure of the enzyme in complex with substrate reveals that the active site enforces a horseshoe-shaped conformation on GSH, and effectively positions the thiol group for activation by a nearby arginine at the membrane-enzyme interface. In addition, the structure provides a model for how the omega-end of the lipophilic co-substrate is pinned at one end of a hydrophobic cleft, providing a molecular 'ruler' to align the reactive epoxide at the thiol of glutathione. This provides new structural insights into the mechanism of LTC4 formation, and also suggests that the observed binding and activation of GSH might be common for a family of homologous proteins important for inflammatory and detoxification responses. 相似文献
94.
95.
Spatio-temporal transcriptome of the human brain 总被引:1,自引:0,他引:1
96.
Persistence of soil organic matter as an ecosystem property 总被引:65,自引:0,他引:65
Schmidt MW Torn MS Abiven S Dittmar T Guggenberger G Janssens IA Kleber M Kögel-Knabner I Lehmann J Manning DA Nannipieri P Rasse DP Weiner S Trumbore SE 《Nature》2011,478(7367):49-56
Globally, soil organic matter (SOM) contains more than three times as much carbon as either the atmosphere or terrestrial vegetation. Yet it remains largely unknown why some SOM persists for millennia whereas other SOM decomposes readily--and this limits our ability to predict how soils will respond to climate change. Recent analytical and experimental advances have demonstrated that molecular structure alone does not control SOM stability: in fact, environmental and biological controls predominate. Here we propose ways to include this understanding in a new generation of experiments and soil carbon models, thereby improving predictions of the SOM response to global warming. 相似文献
97.
稻瘟病菌(Magnaporthe Grisea)引起的水稻稻瘟病是世界水稻生产最具毁灭性的病害之一,也是研究植物与病原物相互作用分子机理的模式系统之一.真菌分泌蛋白由于其本身所具有的分泌特性极有可能成为被宿主植物识别的作用病菌分泌蛋白,该研究到目前为止还比较有限. 文章证明了稻瘟病菌分泌蛋白的存在并且检验了其中几个蛋白在其宿主植物水稻中的诱导因子作用. 通过同源基因的时空表达技术,表明分泌蛋白在稻瘟病菌中大量表达.其中两个在稻瘟病菌中的未知蛋白被测试出具有诱导因子作用. 相似文献
98.
Melanoma mouse model implicates metabotropic glutamate signaling in melanocytic neoplasia 总被引:3,自引:0,他引:3
Pollock PM Cohen-Solal K Sood R Namkoong J Martino JJ Koganti A Zhu H Robbins C Makalowska I Shin SS Marin Y Roberts KG Yudt LM Chen A Cheng J Incao A Pinkett HW Graham CL Dunn K Crespo-Carbone SM Mackason KR Ryan KB Sinsimer D Goydos J Reuhl KR Eckhaus M Meltzer PS Pavan WJ Trent JM Chen S 《Nature genetics》2003,34(1):108-112
99.
100.
High-level circuits in the brain that control the direction of gaze are intimately linked with the control of visual spatial attention. Immediately before an animal directs its gaze towards a stimulus, both psychophysical sensitivity to that visual stimulus and the responsiveness of high-order neurons in the cerebral cortex that represent the stimulus increase dramatically. Equivalent effects on behavioural sensitivity and neuronal responsiveness to visual stimuli result from focal electrical microstimulation of gaze control centres in monkeys. Whether the gaze control system modulates neuronal responsiveness in sensory modalities other than vision is unknown. Here we show that electrical microstimulation applied to gaze control circuitry in the forebrain of barn owls regulates the gain of midbrain auditory responses in an attention-like manner. When the forebrain circuit was activated, midbrain responses to auditory stimuli at the location encoded by the forebrain site were enhanced and spatial selectivity was sharpened. The same stimulation suppressed responses to auditory stimuli represented at other locations in the midbrain map. Such space-specific, top-down regulation of auditory responses by gaze control circuitry in the barn owl suggests that the central nervous system uses a common strategy for dynamically regulating sensory gain that applies across modalities, brain areas and classes of vertebrate species. This approach provides a path for discovering mechanisms that underlie top-down gain control in the central nervous system. 相似文献