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排序方式: 共有350条查询结果,搜索用时 15 毫秒
91.
Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits 总被引:1,自引:0,他引:1
Kim YJ Go MJ Hu C Hong CB Kim YK Lee JY Hwang JY Oh JH Kim DJ Kim NH Kim S Hong EJ Kim JH Min H Kim Y Zhang R Jia W Okada Y Takahashi A Kubo M Tanaka T Kamatani N Matsuda K;MAGIC consortium Park T Oh B Kimm K Kang D Shin C Cho NH Kim HL Han BG Lee JY Cho YS 《Nature genetics》2011,43(10):990-995
To identify the genetic bases for nine metabolic traits, we conducted a meta-analysis combining Korean genome-wide association results from the KARE project (n = 8,842) and the HEXA shared control study (n = 3,703). We verified the associations of the loci selected from the discovery meta-analysis in the replication stage (30,395 individuals from the BioBank Japan genome-wide association study and individuals comprising the Health2 and Shanghai Jiao Tong University Diabetes cohorts). We identified ten genome-wide significant signals newly associated with traits from an overall meta-analysis. The most compelling associations involved 12q24.11 (near MYL2) and 12q24.13 (in C12orf51) for high-density lipoprotein cholesterol, 2p21 (near SIX2-SIX3) for fasting plasma glucose, 19q13.33 (in RPS11) and 6q22.33 (in RSPO3) for renal traits, and 12q24.11 (near MYL2), 12q24.13 (in C12orf51 and near OAS1), 4q31.22 (in ZNF827) and 7q11.23 (near TBL2-BCL7B) for hepatic traits. These findings highlight previously unknown biological pathways for metabolic traits investigated in this study. 相似文献
92.
国际间节能减碳相关产业的发展状况 总被引:1,自引:0,他引:1
由于温室效应对于全球气候变化的影响已经相当显著,因此许多国家与产业都将投入大量资源以努力降低全球气候变化的影响,其中当然隐现着未来全球节能减碳领域的庞大新商机,各项节能减碳相关创新技术因而相继发展.笔者指出,节能减碳产业是藉由材料、设备、制程以及产品之改善,以达成节能减碳目的之产业,其产业范畴可略分为节能材料、节能设备及产品、系统能源整合、节能减碳认验证、碳资产管理等.综述了国际间节能减碳相关产业之发展现状及发展趋势.指出,面对未来之挑战,应确实评估节能减碳相关产业之发展潜力,确定发展对象,擘划出适合节能减碳之产业发展策略及措施. 相似文献
93.
The antimitotic agent taxol was tested for toxicity towards fungi from different taxonomic groups and found to be particularly active against oomycete fungi. In germinating zoospore cysts of the oomycete Phytophthora capsici the mechanism of action of taxol was shown to involve inhibition of mitosis, presumably resulting from an effect on microtubules. Various taxol analogues with deleted A-ring C-13 side chain substituents were tested for toxicity towards P. capsici and Aphanomyces cochlioides to provide insight into structural features required for activity. The importance of the side chain was shown by the much lower activity as compared to taxol of analogues lacking all or part of the side chain. The effect of stereochemistry at the C-2' position on fungitoxicity towards oomycetes was similar to that reported previously on mammalian microtubule assembly. 相似文献
94.
提出了各种网络集成管理的TMN—DCN设计方法,并举出了应用示例。TMN—DCN设备可按各个网络配置。这些设备具有网络管理功能。规模非常大的网络分配多个TMN—DCN设备。下一阶段则利用作为TMN-DCN节点的TMN-DCN设备设计TMN—DCN的布局(物理结构)。 相似文献
95.
96.
Mutations in NYX, encoding the leucine-rich proteoglycan nyctalopin, cause X-linked complete congenital stationary night blindness 总被引:12,自引:0,他引:12
Bech-Hansen NT Naylor MJ Maybaum TA Sparkes RL Koop B Birch DG Bergen AA Prinsen CF Polomeno RC Gal A Drack AV Musarella MA Jacobson SG Young RS Weleber RG 《Nature genetics》2000,26(3):319-323
During development, visual photoreceptors, bipolar cells and other neurons establish connections within the retina enabling the eye to process visual images over approximately 7 log units of illumination. Within the retina, cells that respond to light increment and light decrement are separated into ON- and OFF-pathways. Hereditary diseases are known to disturb these retinal pathways, causing either progressive degeneration or stationary deficits. Congenital stationary night blindness (CSNB) is a group of stable retinal disorders that are characterized by abnormal night vision. Genetic subtypes of CSNB have been defined and different disease actions have been postulated. The molecular bases have been elucidated in several subtypes, providing a better understanding of the disease mechanisms and developmental retinal neurobiology. Here we have studied 22 families with 'complete' X-linked CSNB (CSNB1; MIM 310500; ref. 4) in which affected males have night blindness, some photopic vision loss and a defect of the ON-pathway. We have found 14 different mutations, including 1 founder mutation in 7 families from the United States, in a novel candidate gene, NYX. NYX, which encodes a glycosylphosphatidyl (GPI)-anchored protein called nyctalopin, is a new and unique member of the small leucine-rich proteoglycan (SLRP) family. The role of other SLRP proteins suggests that mutant nyctalopin disrupts developing retinal interconnections involving the ON-bipolar cells, leading to the visual losses seen in patients with complete CSNB. 相似文献
97.
Redundant roles for the TFIID and SAGA complexes in global transcription 总被引:32,自引:0,他引:32
Lee TI Causton HC Holstege FC Shen WC Hannett N Jennings EG Winston F Green MR Young RA 《Nature》2000,405(6787):701-704
98.
CD1c-mediated T-cell recognition of isoprenoid glycolipids in Mycobacterium tuberculosis infection 总被引:7,自引:0,他引:7
Moody DB Ulrichs T Mühlecker W Young DC Gurcha SS Grant E Rosat JP Brenner MB Costello CE Besra GS Porcelli SA 《Nature》2000,404(6780):884-888
The discovery of the CD1 antigen presentation pathway has expanded the spectrum of T-cell antigens to include lipids, but the range of natural lipid antigens and functions of CD1-restricted T cells in vivo remain poorly understood. Here we show that the T-cell antigen receptor and the CD1c protein mediate recognition of an evolutionarily conserved family of isoprenoid glycolipids whose members include essential components of protein glycosylation and cell-wall synthesis pathways. A CD1c-restricted, mycobacteria-specific T-cell line recognized two previously unknown mycobacterial hexosyl-1-phosphoisoprenoids and structurally related mannosyl-beta1-phosphodolichols. Responses to mannosyl-beta1-phosphodolichols were common among CD1c-restricted T-cell lines and peripheral blood T lymphocytes of human subjects recently infected with M. tuberculosis, but were not seen in naive control subjects. These results define a new class of broadly distributed lipid antigens presented by the CD1 system during infection in vivo and suggest an immune mechanism for recognition of senescent or transformed cells that are known to have altered dolichol lipids. 相似文献
99.
W. Young 《Cellular and molecular life sciences : CMLS》1973,29(7):802-804
Zusammenfassung Die Acetylcholin-Esterase-Aktivität und die Kontraktilität wird am isolierten Frosch-Herzen unter steigendem hydrostatischem Druck untersucht. Ohne wesentliche Veränderung der Molekül-Dimension wird ein Anstieg der Hydrolyse von Acetylcholin bewirkt.
National Academy of Sciences, National Research Council, Senior postdoctoral Resident Research associate. 相似文献
National Academy of Sciences, National Research Council, Senior postdoctoral Resident Research associate. 相似文献