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Interleukin-1 polymorphisms associated with increased risk of gastric cancer 总被引:190,自引:0,他引:190
El-Omar EM Carrington M Chow WH McColl KE Bream JH Young HA Herrera J Lissowska J Yuan CC Rothman N Lanyon G Martin M Fraumeni JF Rabkin CS 《Nature》2000,404(6776):398-402
Helicobacter pylori infection is associated with a variety of clinical outcomes including gastric cancer and duodenal ulcer disease. The reasons for this variation are not clear, but the gastric physiological response is influenced by the severity and anatomical distribution of gastritis induced by H. pylori. Thus, individuals with gastritis predominantly localized to the antrum retain normal (or even high) acid secretion, whereas individuals with extensive corpus gastritis develop hypochlorhydria and gastric atrophy, which are presumptive precursors of gastric cancer. Here we report that interleukin-1 gene cluster polymorphisms suspected of enhancing production of interleukin-1-beta are associated with an increased risk of both hypochlorhydria induced by H. pylori and gastric cancer. Two of these polymorphism are in near-complete linkage disequilibrium and one is a TATA-box polymorphism that markedly affects DNA-protein interactions in vitro. The association with disease may be explained by the biological properties of interleukin-1-beta, which is an important pro-inflammatory cytokine and a powerful inhibitor of gastric acid secretion. Host genetic factors that affect interleukin-1-beta may determine why some individuals infected with H. pylori develop gastric cancer while others do not. 相似文献
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Edith Jones Norma Gaytan Iraselia Garcia Alan Herrera Manuel Ramos Divya Agarwala Maahrose Rana Wendy Innis-Whitehouse Erin Schuenzel Robert Gilkerson 《Cellular and molecular life sciences : CMLS》2017,74(7):1347-1363
As an organellar network, mitochondria dynamically regulate their organization via opposing fusion and fission pathways to maintain bioenergetic homeostasis and contribute to key cellular pathways. This dynamic balance is directly linked to bioenergetic function: loss of transmembrane potential across the inner membrane (Δψ m) disrupts mitochondrial fission/fusion balance, causing fragmentation of the network. However, the level of Δψ m required for mitochondrial dynamic balance, as well as the relative contributions of fission and fusion pathways, have remained unclear. To explore this, mitochondrial morphology and Δψ m were examined via confocal imaging and tetramethyl rhodamine ester (TMRE) flow cytometry, respectively, in cultured 143B osteosarcoma cells. When normalized to the TMRE value of untreated 143B cells as 100%, both genetic (mtDNA-depleted ρ0) and pharmacological [carbonyl cyanide m-chlorophenyl hydrazone (CCCP)-treated] cell models below 34% TMRE fluorescence were unable to maintain mitochondrial interconnection, correlating with loss of fusion-active long OPA1 isoforms (L-OPA1). Mechanistically, this threshold is maintained by mechanistic coordination of DRP1-mediated fission and OPA1-mediated fusion: cells lacking either DRP1 or the OMA1 metalloprotease were insensitive to loss of Δψ m, instead maintaining an obligately fused morphology. Collectively, these findings demonstrate a mitochondrial ‘tipping point’ threshold mediated by the interaction of Δψ m with both DRP1 and OMA1; moreover, DRP1 appears to be required for effective OPA1 maintenance and processing, consistent with growing evidence for direct interaction of fission and fusion pathways. These results suggest that Δψ m below threshold coordinately activates both DRP1-mediated fission and OMA1 cleavage of OPA1, collapsing mitochondrial dynamic balance, with major implications for a range of signaling pathways and cellular life/death events. 相似文献
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Resumen Se estudiaron las actividades de glucosa-6-fosfato dehidrogenasa y 6-fosfogluconato dehidrogenasa en hígado y tejido adiposo de ratas preñadas, al día 19 de gestación, alimentadas y en ayunas de 48 h, relacionando los resultados obtenidos con la velocidad de síntesis de ácidos grasos en el tejido adiposo de los mismos animales.
This study was carried out at the Section of Endocrinology and Metabolism, Departments of Medicine and Biochemistry, Northwestern University Medical School, Chicago, Ill, USA. The authors are indepted to Dr.N. Freinkel for his encouragement. This work was supported in part by Research Grant AM-10699 and Training Grant AM-05071 from the National Institute of Arthritis and Metabolic Diseases, U.S. Public Health Service, Bethesda, Maryland, USA. 相似文献
This study was carried out at the Section of Endocrinology and Metabolism, Departments of Medicine and Biochemistry, Northwestern University Medical School, Chicago, Ill, USA. The authors are indepted to Dr.N. Freinkel for his encouragement. This work was supported in part by Research Grant AM-10699 and Training Grant AM-05071 from the National Institute of Arthritis and Metabolic Diseases, U.S. Public Health Service, Bethesda, Maryland, USA. 相似文献