全文获取类型
收费全文 | 21683篇 |
免费 | 154篇 |
国内免费 | 292篇 |
专业分类
系统科学 | 287篇 |
丛书文集 | 281篇 |
教育与普及 | 140篇 |
理论与方法论 | 76篇 |
现状及发展 | 5823篇 |
研究方法 | 770篇 |
综合类 | 14434篇 |
自然研究 | 318篇 |
出版年
2015年 | 163篇 |
2014年 | 248篇 |
2013年 | 458篇 |
2012年 | 511篇 |
2011年 | 905篇 |
2010年 | 421篇 |
2009年 | 416篇 |
2008年 | 643篇 |
2007年 | 698篇 |
2006年 | 643篇 |
2005年 | 604篇 |
2004年 | 499篇 |
2003年 | 435篇 |
2002年 | 442篇 |
2001年 | 841篇 |
2000年 | 811篇 |
1999年 | 586篇 |
1998年 | 221篇 |
1997年 | 187篇 |
1996年 | 167篇 |
1992年 | 426篇 |
1991年 | 348篇 |
1990年 | 352篇 |
1989年 | 371篇 |
1988年 | 311篇 |
1987年 | 300篇 |
1986年 | 308篇 |
1985年 | 316篇 |
1984年 | 270篇 |
1983年 | 245篇 |
1982年 | 203篇 |
1981年 | 188篇 |
1980年 | 211篇 |
1979年 | 502篇 |
1978年 | 391篇 |
1977年 | 365篇 |
1976年 | 302篇 |
1975年 | 348篇 |
1974年 | 496篇 |
1973年 | 376篇 |
1972年 | 386篇 |
1971年 | 491篇 |
1970年 | 607篇 |
1969年 | 413篇 |
1968年 | 448篇 |
1967年 | 377篇 |
1966年 | 384篇 |
1965年 | 259篇 |
1958年 | 225篇 |
1957年 | 162篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
81.
A. Alkofahi J. K. Rupprecht D. L. Smith Ch. -J. Chang J. L. McLaughlin 《Cellular and molecular life sciences : CMLS》1988,44(1):83-85
Summary Using brine shrimp lethality for activity-directed fractionation, goniothalamicin (I), a new tetrahydroxy-mono-tetrahydrofuran fatty acid -lactone (acetogenin), has been isolated from ethanolic extracts of the stem bark ofGoniothalamus giganteus Hook. f., Thomas (Annonaceae). This novel compound was found to be cytotoxic and insecticidal and inhibited the formation of crown gall tumors on potato discs. Annonacin (II), the only other reported mono-tetrahydrofuran acetogenin, was also isolated; the previously reported 9ASK (astrocytoma reversal) activity ofII was confirmed, andII is now also found to be weakly active against 3PS murine leukemia. 相似文献
82.
83.
对城市化途径有关各要素作了综合的叙述,并且指出研究的手段──自人口的聚集至城镇形成发展这一历史的纵剖面及地域、产业结构等横向有关要素作整体系统的分析与比较,并指出应重点研究人口指标分析、产业可比关系、城市化和城市化设施,以及城市体系的研究问题。 相似文献
84.
M. Caron G. Cherqui D. Wicek J. Capeau J. Bertrand J. Picard 《Cellular and molecular life sciences : CMLS》1988,44(1):34-37
Summary Insulin stimulation of glycogen synthesis was nearly abolished in hepatoma cells shortly treated with 4 ß-phorbol 12 \-myristate, 13 -acetate (protein kinase C activation) but remained unmodified in cells chronically treated with the phorbol ester (protein kinase C depletion). Thus, although exogenous activation of protein kinase C results in an inhibition of insulin action, protein kinase C depletion has no influence on this process. The results suggest that, in hepatoma cells, no endogenous activation of protein kinase C may occur in response to the signal triggered by insulin. 相似文献
85.
D. Porquet M. Appel T. Fournier O. Bertaux D. Biou J. Féger 《Cellular and molecular life sciences : CMLS》1992,48(3):257-261
Both in vivo and in vitro models have certain disadvantages for the study of the chronic hepatotoxicity of drugs. The aim of this work was to evaluate a new approach based on an in vivo/in vitro model. After chronic in vivo treatment of rats with Vincamine and Vindeburnol (an eburnamenine derivative which exhibits hepatotoxic properties in man) liver cells were isolated, and functional and metabolic disorders (metabolic utilization of fructose and protein biosynthesis) were studied to determine injury. The results showed no modification of blood parameters, but a direct relationship between the dose of Vindeburnol administered in vivo and the metabolic disorders observed in vitro, evidencing the high sensitivity and reliability of this model. 相似文献
86.
夏家祚 《解放军理工大学学报(自然科学版)》1992,(2)
轨道偏离赤道平面的同步卫星,其星下点(或视位置)的口漂移轨迹址对称于静止位置的“8”字形。文献[1]给出的数学表达式对“8”字形轨迹的解释不直观,物理图象欠清晰。本文给出新的数学表达式,能用图示法形象直观地描绘出“8”字形轨迹,并简明地给出“8”字形的高度和宽度。 相似文献
87.
R. Wiesendanger B. Martinoni T. Boller D. Arigoni 《Cellular and molecular life sciences : CMLS》1986,42(2):207-209
Summary Under the action of the appropriate synthase from ripe tomatoes a 11 mixture of (3S, 4R)-[3,4-2H2] and (3R, 4S)-[3,4-2H2]-(2S)-adenosylmethionine is transformed into a 11 mixture of the two meso forms of [2H2]-1-aminocyclopropanecarboxylic acid, a result which proves the operation of an inversion mechanism and which is consistent with direct nucleophilic displacement of the leaving group in the substrate. 相似文献
88.
D. Dubourdieu 《Cellular and molecular life sciences : CMLS》1986,42(8):914-921
Conclusion Current enological research does not aim at developing technological wines whose organoleptic characteristics are basically determined by the methods used in the transformation of grape wine, but rather to refine methods which will highlight the original qualities of different cultivars and viticultural conditions. 相似文献
89.
Evolution of the atmosphere and oceans 总被引:1,自引:0,他引:1
The residence times of most constituents of the atmosphere and oceans are small fractions of the age of the Earth and, in general, their rate of output has been nearly equal to their rate of input. We are disturbing a number of these dynamic equilibria quite severely. The mineralogy of marine evaporites rules out drastic changes in the composition of sea water during the last 900 Myr. The chemistry of soils formed more than 1,000 Myr ago suggests that the atmosphere then contained significantly more CO2 and less O2 than at present. Hydrogen peroxide may well have been the principal oxidant and formaldehyde the main reductant in rain water between 3,000 and 1,000 Myr ago. Major changes in atmospheric chemistry since that time are almost certainly related to the evolution of the biosphere. 相似文献
90.
Antidiuretic effects of oxytocin in the Brattleboro rat 总被引:1,自引:0,他引:1
J. Lyness A. G. Robinson M. N. Sheridan D. M. Gash 《Cellular and molecular life sciences : CMLS》1985,41(11):1444-1446
Summary The antidiuretic activity of oxytocin (OT) was measured in Brattleboro rats with congenital diabetes insipidus. A dose dependent antidiuretic response was found in animals receiving chronic infusions of 0.1 g/h, 1.0 g/h, and 5 g/h of OT. OT infused at the rate of 5 g/h over a 7-day period completely reversed the symptoms of diabetes insipidus. The results support the concept that OT serves as a weak agonist of vasopressin at the level of the kidney and at pharmacological levels exhibits antidiuretic activity. 相似文献