Lysergic acid diethylamide affects blood flow to specific areas of the conscious rat brain

Zusammenfassung Die i.v. Verabreichung von LSD an Ratten steigert den Blutkreislauf im Hirnstamm sowie im frontalen und parietalen Cortex selektiv. Es wurden durch 6-Nor-LSD, 2-Methyl-LSD und ^{8, 9}-LSD weder wahrnehmbare Verhaltensänderungen noch Änderungen des regionalen Blutkreislaufs verursacht.     

Conservation of cytoplasmic poly (A)-containing RNA in mouse and rat.

By comparing the melting temperature of DNA-DNA duplexes between related species, it is shown that total single-copy DNA evolves at a faster rate that DNA which is transcribed into poly (A)-containing RNA. Such a comparison suggests that at least 70% of rat single-copy DNA does not code for protein.     

Nuclear pores in the spermatozoon of the rat

Summary The paper describes a hexagonal array of nuclear pores in a non-redundant region of the nuclear envelope underlying the basal surface of the rat spermatozoon head. It is concluded that intranuclear material protruding through these pores is the cause of the characteristic rows of circular bumps found in surface replicas of this region.     

The structural relationship of phorbol and cortisol: A possible mechanism for the tumor promoting activity of phorbol

Summary The crucial functional groups of phorbol-12-myristate-13-acetate (PMA) are superimposable with those of the glucocorticoid cortisol in a unique manner which suggests a mechanism for PMA activity, i.e. the alkylation of a cortisol receptor.     

The suppression of mouse spontaneous locomotor activity by the ingestion of deuterium oxide.

The spontaneous locomotor activity of the laboratory mouse is significantly depressed by the ingestion of deuterium oxide. The response, which is reversible, is a retilinear one with up to 70% reduction in activity with the administration of 25% heavy water.     

Effect of heat treatment on the ATPase activity of various sarcoplasmic reticulum preparations.

Ca2+-stimulated ATPase activity of sarcoplasmic reticulum (SR) preparations is activated after a short period of preincubation at temperatures between 40 and 45 degrees C, but for temperatures higher than 48 degrees C pronounced denaturation is observed. Heat denaturation is decreased if Mg2+ or K+ are present during heat treatment.     

Regulation of enzymes of ethanol metabolism in yeast (Rhodotorula gracilis)

Summary The three enzymes of ethanol metabolism alcohol dehydrogenase, aldehyde dehydrogenase and acetyl-CoA synthetase in the obligate aerobic yeastRhodotorula gracilis are repressed by glucose and induced by C₂ metabolic fuels with a regulatory pattern indicating a correlation in the control mechanisms. To try an identification of the molecular signals involved in the transmission of the inducing stimulus, experiments were carried out by blocking with 2 mM pyrazole the ethanol acetaldehyde metabolic step. Results indicate that ethanol is not specifically required as a molecular signal for induction.This work was supported by a grant from the Italian Consiglio Nazionale delle Ricerche.