Effect of cholinesterase inhibitors on differentiation of cultured sympathicoblasts

Summary The 2 cholinesterase inhibitors, eserine and BW 284 C 51, inhibited the nerve fibre growth and differentiation of immature sympathicoblasts at low concentrations. The effect was nerve cell-specific and appeared in the course of the in vitro development, indicating that cholinesterases might play an important role in the early differentiation of sympathicoblasts.     

Pseudotumoral uterine reaction in the rat treated with a benzofuro-benzoxepin

When orally administered, 5-(3-diméthylamino propyliden)-benzofuro [2,3-c] benzoxepin-1, which antagonizes several biogenic amines, is slightly sedative and has also endocrinological properties in the Rat, induces the appearance of localized lesions of uterine stroma in 2 to 16% of the animals. The cytological picture could suggest a tumorogenesis. In fact, these lesions represent a non-tumoral reactional hyperplasia with nuclear abnormalities due to a hormonal stimulation.     

Frequency-domain study of the mechanical response of living striated muscle

Summary Small-amplitude sinusoidal displacements, in the frequency rang 4–100 Hz, were applied to intact whole frog sartorius muscle whilst in a state of tetanus. At low frequencies the muscle, was observed to do oscillatory work, while at higher frequencies it tended towards elastic behaviour. Frequency-response plots obtained were compared with those from other muscle preparations. Results were interpreted in terms of mechano-chemical transduction properties of muscle.The authors wish to thank the Australian Research Grants Commission for provision of the laser, and L. I. Patterson for construction of the mechanical apparatus.     

Estrogen receptor in uteri of mice of different H-2 genotypes.

A relationship between the amount of available estradiol receptors in uteri of inbred mice and their H-2 genotype is suggested by study in congenic animals.     

Autoradiographic studies on RNA synthesis and transport in the Salivary gland ofLygaeus sp. (Hemiptera-Lygaeidae)

Summary Autoradiographic studies using³H-uridine in the salivary gland of adultLygaeus sp. were carried out. The gland cell nuclei, particularly the multiple nucleoli, are the sites of incorporation of the label exhibiting RNA synthesis. The labelled molecules (RNA) are transported to the cell cytoplasm and then into the gland lumen in which no turnover of the radioactivity is observed.I am grateful to my teacher, Prof. P. S. Ramamurty, School of Life Sciences, University of Hyderabad, for his constant inspiration. Grateful acknowledgement is made to Prof. J. P. Thapliyal, Dept of Zoology, B. H. U. for encouragement and to Dr Om Prakash, Dept of Biochemistry, B. H. U. for his valuable criticism.     

Effects of thalidomide on the skeleton of the rat foetus

Zusammenfassung Nach Thalidomidverabreichung an trächtigen Ratten fanden wir Fruchtresorption und Anomalien am fünften Brustbeinkern der Föten. Weitere ergänzende Skelettuntersuchungen ergaben, besonders bei mittelgrossen Thalidomidgaben, Verknöcherungs-störungen an den Halswirbelkörpern. Andere Skeletteile zeigten keine Thalidomid-abhängigen Entwicklungsvariationen.