DDT: The degradation of ring-labeled14C-DDT to14CO2 in the rat

Summary Ring fission ofp, p-DDT was studied in the rat following a single oral dose of 0.74 mg/kg (1.04 Ci) of uniformly ring-labeled¹⁴C-DDT. Expired air was passed through a solution of ethanolamine-ethylene glycol monomethyl ether (12) to trap¹⁴CO₂. A total of 1.6% of the radioactivity administered was recovered in the expired air collected continually for 10 days, indicating that while degradation of the phenyl moiety is not a major route pfp, p-DDT metabolism in the rat, it is equal to the urinary excretion. Nevertheless, these results represent the most radical change accomplished in vivo of a residual insecticide yet reported in mammals.Acknowledgment. We acknowledge the secretarial work of Ms.Elaine Smolko. This study was supported by NIH fellowship No. 1 F22 ES01723-01 and No. HL16264.     

Blood plasma investigations by resonance raman spectroscopy: Detection of carotenoid pigments

Summary Using Raman spectroscopy, we demonstrate that low levels of -carotene, lycopene, and xanthophyll give rise to resonance enhanced bands in blood plasma. These results explain the significance of previously unidentified spectral maxima which have been related to the state of health of the blood donor.     

4-Isothiocyanato-4′-nitrodiphenylamine (C9333-Go/CGP 4540) an anthelminthic with an unusual spectrum of activity against intestinal nematodes,filariae and schistosomes

Summary 4-isothiocyanato-4-nitrodiphenylamine was found to possess activity against intestinal nematodes in mice, against schistosomes in various hosts including primates and against two filarial species in the mongolian jird. Upon administration in a single oral dose it is equally effective againstS. haematobium, S. mansoni andS. japonicum.     

Differential effects of ethanol on prostaglandin responses of arterial and venous smooth muscle

Summary The present results, using isolated rat aortic strips and portal vein segments, demonstrate that ethanol, depending upon concentration, can either enhance or attenuate the contractile actions of PGF₂ on at least 2 different types of vascular smooth muscle. At the very least, the present findings question the use of ethanol as a solvent when investigating the contractile actions of PG molecules on smooth muscles.Supported by NIH grant No. HL-18015 and NIMH grant No. MH-26236. The authors are indebted to Dr.John E. Pike and Dr.John Babcock of the Upjohn Company for generously providing us with the PGF₂ used in this study.     

Influence of cyclic nucleotides on protein synthesis in vascular smooth muscle

Summary The incorporation of leucice-¹⁴C into protein in bovine mesenteric arteries was augmented by cyclic GMP (10^–3 M) and decreased by cyclic AMP (10^–3 M). There was no effect of 5 AMP (10^–3 M). The phosphodiesterase inhibiting drugs theophylline (10^–3 M) and papaverine (5×10^–5 g/ml) both decreased the leucine-¹⁴C incorporation.We are indebted to Mrs.Lena Burlin for hear assistance. Finacial support has been provided by the Swedish State Medical Research Council (No. 04X-101X-4498).     

Ecdysone 20-hydroxylase from the midgut of the tobacco hornworm (Manduca sexta L.)

Summary An ecdysone 20-hydroxylase enzyme system that converts -ecdysone to 20-hydroxyecdysone was prepared from the midgut of the tobacco hornworm prepupa. This partially purified enzyme is NADPH dependent and is localized in the mitochondrial fraction of the midgut tissue.     

Effect of 723-1723-1723-1on ethanol withdrawal in mice

Summary ⁹ (10 mg/kg, i.p.) administered to mice immediately after withdrawal from a 3-day exposure to ethanol vapor was found to intensify withdrawal reactions. No effect was seen when ⁹ was administered chronically during the exposure to ethanol.     

Octopamine,dopamine and noradrenaline content of the brain of the locust,Schistocerca gregaria

Summary The octopamine, dopamine and noradrenaline content of the brain of the locust,Schistocerca gregaria has been determined using sensitive radiochemical-enzymatic assays. Octopamine and dopamine are present in high concentration but the noradrenaline content is only 1/25 that of octopamine. Both reserpine and fusaric acid (a dopamine--hydroxylase inhibitor) produce a significant depletion of the octopamine stores.The author is a M.R.C. of Canada Fellow. Thanks are due to Drs.A. A. Boulton, A. V. Juorio, andP. H. Wu for helpful discussion.     

γ-Al2O3载体孔内原位合成水滑石

以尿素为沉淀剂,利用γ-Al2O3的内孔表面铝源原位合成水滑石. 考察了晶化时间、晶化温度、初始溶液浓度、原料配比对原位合成水滑石的影响. 实验中发现晶化6 h,MgAlCO3-LDH的晶体结构已趋于完整,晶化时间大于6 h时会有NH4Al(OH)2CO3*H2O杂相生成.在实验条件范围内,生成的一次粒子大小随着晶化时间的延长逐渐增大,随着晶化温度的升高、初始溶液浓度的增大而减小.     

二苯并四氧二氮环醚及其稀土配合物合成与荧光性质研究

合成了二十员大环双氮杂冠醚：2，3，l6，l7—二苯—l，8，ll，18—四氧—5，14—二氮杂环二十烷及其7个与稀土硝酸盐(RE^3 ＝La^3 ，Sm^3 ，Eu^3 ，Gd^3 ，Tb^3 ，Dy^3 。Yb^3 )所形成的1：2(M：L)型固体配合物，并经过红外光谱、元素分析、摩尔电导及热分析等方法对配合物进行了表征．结果表明，配位是通过配体中的C—O-C进行的，而Ar—O-C未参与配位，同时含2分子配位水．对Sm(Ⅲ)，Eu(Ⅲ)，Tb(Ⅲ)，Dy(Ⅲ)的配合物进行了荧光光谱测定，所有配合物均有较强的荧光强度，其中Tb(Ⅲ)的配合物荧光强度最高，表明该新双氮杂冠醚配体三重态的能量与Tb(Ⅲ)的振动能级最为匹配．