Variations in cardiac noradrenaline content during sodium loading in hypertension prone and resistant rats

Summary The cardiac catecholamine content of Sabra rats and their 2 genetically derived substrains, hypertension prone and resistant rats, was studied by high pressure liquid chromatography and electrochemical detection. Both in the control period and after sodium and DOCA administration the cardiac noradrenaline level is higher in hypertension resistant rats than in Sabra rats, and also higher than in hypertension prone rats. This finding suggests that a reduction of the cardiac sympathetic nervous tone is involved in the genetic resistance to sodium.     

Induction of chromosome abnormalities by reversal of colcemid inhibition in leucocyte cultures

Zusammenfassung Menschliche Leukozyten, die vorher 2 resp. 4 h der Wirkung von Colcemid ausgesetzt worden waren, ergaben in Zellkulturen 45 resp. über 50% Zellen mit 45 oder weniger Chromosomen im Vergleich zu 10% in Kontrollkulturen ohne Colcemid.

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This work is supported financially by Schering Chemicals Ltd., Burgess Hill, Sussex. We would like to thank Dr.A. G. Pitchford for advice and MissE. Gristwood for technical assistance.