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981.
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Kinchen JM Cabello J Klingele D Wong K Feichtinger R Schnabel H Schnabel R Hengartner MO 《Nature》2005,434(7029):93-99
The removal of apoptotic cells is essential for the physiological well being of the organism. In Caenorhabditis elegans, two conserved, partially redundant genetic pathways regulate this process. In the first pathway, the proteins CED-2, CED-5 and CED-12 (mammalian homologues CrkII, Dock180 and ELMO, respectively) function to activate CED-10 (Rac1). In the second group, the candidate receptor CED-1 (CD91/LRP/SREC) probably recognizes an unknown ligand on the apoptotic cell and signals via its cytoplasmic tail to the adaptor protein CED-6 (hCED-6/GULP), whereas CED-7 (ABCA1) is thought to play a role in membrane dynamics. Molecular understanding of how the second pathway promotes engulfment of the apoptotic cell is lacking. Here, we show that CED-1, CED-6 and CED-7 are required for actin reorganization around the apoptotic cell corpse, and that CED-1 and CED-6 colocalize with each other and with actin around the dead cell. Furthermore, we find that the CED-10(Rac) GTPase acts genetically downstream of these proteins to mediate corpse removal, functionally linking the two engulfment pathways and identifying the CED-1, -6 and -7 signalling module as upstream regulators of Rac activation. 相似文献
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Spatial regulation of beta-actin translation by Src-dependent phosphorylation of ZBP1 总被引:2,自引:0,他引:2
Hüttelmaier S Zenklusen D Lederer M Dictenberg J Lorenz M Meng X Bassell GJ Condeelis J Singer RH 《Nature》2005,438(7067):512-515
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Cyanobacteria, and the viruses (phages) that infect them, are significant contributors to the oceanic 'gene pool'. This pool is dynamic, and the transfer of genetic material between hosts and their phages probably influences the genetic and functional diversity of both. For example, photosynthesis genes of cyanobacterial origin have been found in phages that infect Prochlorococcus and Synechococcus, the numerically dominant phototrophs in ocean ecosystems. These genes include psbA, which encodes the photosystem II core reaction centre protein D1, and high-light-inducible (hli) genes. Here we show that phage psbA and hli genes are expressed during infection of Prochlorococcus and are co-transcribed with essential phage capsid genes, and that the amount of phage D1 protein increases steadily over the infective period. We also show that the expression of host photosynthesis genes declines over the course of infection and that replication of the phage genome is a function of photosynthesis. We thus propose that the phage genes are functional in photosynthesis and that they may be increasing phage fitness by supplementing the host production of these proteins. 相似文献
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Gehrels N Sarazin CL O'Brien PT Zhang B Barbier L Barthelmy SD Blustin A Burrows DN Cannizzo J Cummings JR Goad M Holland ST Hurkett CP Kennea JA Levan A Markwardt CB Mason KO Meszaros P Page M Palmer DM Rol E Sakamoto T Willingale R Angelini L Beardmore A Boyd PT Breeveld A Campana S Chester MM Chincarini G Cominsky LR Cusumano G de Pasquale M Fenimore EE Giommi P Gronwall C Grupe D Hill JE Hinshaw D Hjorth J Hullinger D Hurley KC Klose S Kobayashi S Kouveliotou C Krimm HA Mangano V 《Nature》2005,437(7060):851-854
Gamma-ray bursts (GRBs) come in two classes: long (> 2 s), soft-spectrum bursts and short, hard events. Most progress has been made on understanding the long GRBs, which are typically observed at high redshift (z approximately 1) and found in subluminous star-forming host galaxies. They are likely to be produced in core-collapse explosions of massive stars. In contrast, no short GRB had been accurately (< 10') and rapidly (minutes) located. Here we report the detection of the X-ray afterglow from--and the localization of--the short burst GRB 050509B. Its position on the sky is near a luminous, non-star-forming elliptical galaxy at a redshift of 0.225, which is the location one would expect if the origin of this GRB is through the merger of neutron-star or black-hole binaries. The X-ray afterglow was weak and faded below the detection limit within a few hours; no optical afterglow was detected to stringent limits, explaining the past difficulty in localizing short GRBs. 相似文献