Quantum metallicity in a two-dimensional insulator

One of the most far-reaching problems in condensed-matter physics is to understand how interactions between electrons, and the resulting correlations, affect the electronic properties of disordered two-dimensional systems. Extensive experimental and theoretical studies have shown that interaction effects are enhanced by disorder, and that this generally results in a depletion of the density of electronic states. In the limit of strong disorder, this depletion takes the form of a complete gap in the density of states. It is known that this 'Coulomb gap' can turn a pure metal film that is highly disordered into a poorly conducting insulator, but the properties of these insulators are not well understood. Here we investigate the electronic properties of disordered beryllium films, with the aim of disentangling the effects of the Coulomb gap and the underlying disorder. We show that the gap is suppressed by a magnetic field and that this drives the strongly insulating beryllium films into a low-temperature 'quantum metal' phase with resistance near the quantum resistance RQ = h/e2, where h is Planck's constant and e is the electron charge.     

Role of neurotransmitter release and cyclic AMP-dependent membrane phosphorylation in low voltage myocardial automaticity

Low voltage myocardial automaticity (LVA) was investigated by pharmacological modulations of the presynaptic and postsynaptic processes. The sensitivity of LVA both to inhibitor and stimulator of neurotransmitter release suggests its involvement in LVA genesis. Moreover, LVA is blocked by the inhibition of the cyclic AMP system, supporting the participation of the c-AMP-dependent membrane phosphorylation in calcium-mediated cardiac electrogenesis.     

硫化铅量子点的能带调控

摘要：纳米材料的研究在近年来是材料科学中研究的重点方向,而纳米硫化铅作为新型的具有特殊光学性能的材料在各个领域都受到广泛应用。我们通过实验以求控制其量子点的颗粒变化,从而进一步研究其本身性质的改变。文中我们采用化学液相法,使用溶液混合反应共沉淀制备硫化铅量子点,并通过X射线衍射（XRD）、透射电子显微镜（TEM）和紫外可见分光光度计（UV-vis）进行表征分析。实验过程中我们成功的通过调制反应溶液的浓度和添加表面活性剂的方法改变了硫化铅量子点的颗粒尺寸,制备了粒径由7nm到20nm的硫化铅量子点。颗粒尺寸的变化也导致了量子点光学特性和能带的改变。从实验的结果上可看出,实验成功制备了结晶性良好的纯硫化铅量子点,再通过形貌及性能的表征分析后,发现量子点的能带岁颗粒尺寸大小变化的规律。通过对量子点本身光学性能的研究,我们可以使其在太阳能电池等领域获得更好的应用,同时对新型材料的发展起到促进作用。关键词：硫化铅;量子点;能带;调控     

Effect of recombinant human granulocyte colony-stimulating factor on human neutrophil adherence in vitro.

We measured the effects of recombinant human granulocyte-colony stimulating factor (rhG-CSF) on the adherence of human neutrophils by using a dacron fiber system to assay the adhesive ability of neutrophils. rhG-CSF enhanced neutrophil adherence to dacron fibers. N-formyl-methionyl-leucyl-phenylalanine (fMLP) induced neutrophil-neutrophil interaction (neutrophil aggregation) in addition to neutrophil-dacron interaction, whereas rhG-CSF did not cause neutrophil aggregation. These results indicated that rhG-CSF increases the adhesive ability of neutrophils without neutrophil-neutrophil interaction, and the action of rhG-CSF in neutrophil activation is different from the neutrophil activation caused by fMLP.     

Mapping of mutation causing Friedreich's ataxia to human chromosome 9

Friedreich's ataxia is an autosomal recessive disease with progressive degeneration of the central and peripheral nervous system. The biochemical abnormality underlying the disorder has not been identified. Prompted by the success in localizing the mutations causing Duchenne muscular dystrophy, Huntington's disease and cystic fibrosis, we have undertaken molecular genetic linkage studies to determine the chromosomal site of the Friedreich's ataxia mutation as an initial step towards the isolation and characterization of the defective gene. We report the assignment of the gene mutation for this disorder to chromosome 9p22-CEN by genetic linkage to an anonymous DNA marker MCT112 and the interferon-beta gene probe. In contrast to the clinical variation seen for the disorder, no evidence of genetic heterogeneity is observed.     

Nerve-growth promoting action of isaxonine in rat

Summary After sciatic nerve lesion by freezing, the length of the most rapidly regenerating fibres was significantly increased by i.p. injection of isaxonine (N-isopropyl-amino-2-pyrimidine orthophosphate) in the rat. A dose-effect relationship was demonstrated. Both sensory and motor function returned earlier in treated animals.     

Disruption of mouse Slx4, a regulator of structure-specific nucleases, phenocopies Fanconi anemia

The evolutionarily conserved SLX4 protein, a key regulator of nucleases, is critical for DNA damage response. SLX4 nuclease complexes mediate repair during replication and can also resolve Holliday junctions formed during homologous recombination. Here we describe the phenotype of the Btbd12 knockout mouse, the mouse ortholog of SLX4, which recapitulates many key features of the human genetic illness Fanconi anemia. Btbd12-deficient animals are born at sub-Mendelian ratios, have greatly reduced fertility, are developmentally compromised and are prone to blood cytopenias. Btbd12(-/-) cells prematurely senesce, spontaneously accumulate damaged chromosomes and are particularly sensitive to DNA crosslinking agents. Genetic complementation reveals a crucial requirement for Btbd12 (also known as Slx4) to interact with the structure-specific endonuclease Xpf-Ercc1 to promote crosslink repair. The Btbd12 knockout mouse therefore establishes a disease model for Fanconi anemia and genetically links a regulator of nuclease incision complexes to the Fanconi anemia DNA crosslink repair pathway.     

一种喹啉类Zn2+荧光比率型探针

以8-氨基喹啉为母体,设计并合成一种Zn2+比率型荧光探针,通过核磁、质谱表征其结构,并利用荧光光谱、紫外-可见吸收光谱等研究了探针的识别性能.结果表明,该探针在pH为4.0~9.5条件下均能有效识别Zn2+,尤其在pH 7.4的生理条件下具有最优的识别能力.探针与Zn2+能形成结合比为1:1的稳定络合物且灵敏度高、选择性强、响应迅速,因此该荧光探针具有在生物及环境等领域有效检测Zn2+的潜力.