Nanoengineering of amino - functionalized mesoporous silica nanospheres as nanoreactors

Selective functionalization of mesoporous silica nanospheres (MSNs) is crucial for nanoengineering of MSNs. Herein, we have combined “surface-protected etching strategy” and “cationic surfactant assisted etching strategy” to prepare functionalized MSNs with externally attached amino groups. The externally attached NH2 groups endow the catalysts with excellent catalytic performance for nitroaldol reaction between nitromethane and benzaldehyde. In addition, those NH2-MSNs can also be used to support gold nanoparticles, which display very good catalytic performance for reduction of 4-nitrophenol. It can be envisioned that the synthesis protocol developed in this work could also be extended to nanoengineered MSNs, which provides opportunities for nanoreactors design.     

诗情与诗意间的裂痕——评华兹华斯诗歌中的一点瑕疵

华兹华斯是英国杰出的浪漫主义诗人。他倡导用老百姓的语言入诗,为浪漫主义诗歌运动写下了纲领性文献——《抒情歌谣集二版序》。但他的诗中也存在些瑕疵,即他的一些诗歌中诗情与诗意间有些许的裂痕,这点在与同时代诗人诗作的比较中可看得更加的清晰。而诗情与诗意二者的化合程度却是评判诗作优劣的最终标准之一。艾略特认为英国自17世纪以后诗歌中出现了"感性脱节"现象。其他英国浪漫主义诗人的诗作中也有类似的瑕疵。     

计算机组成原理实验改革探索

本文在改革计算机组成原理实验从验证到主动设计方面,进行了一定的探索。将EDA技术引入到实验中,由学生在EDA平台MAX-PLUSII上,根据计算机组成原理设计功能部件,将设计结果下载到PLD器件中,最后验证逻辑设计的正确性。     

Purification and cloning of amyloid precursor protein beta-secretase from human brain

Proteolytic processing of the amyloid precursor protein (APP) generates amyloid beta (Abeta) peptide, which is thought to be causal for the pathology and subsequent cognitive decline in Alzheimer's disease. Cleavage by beta-secretase at the amino terminus of the Abeta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated carboxy-terminal fragment. Cleavage of the C-terminal fragment by gamma-secretase(s) leads to the formation of Abeta. The pathogenic mutation K670M671-->N670L671 at the beta-secretase cleavage site in APP, which was discovered in a Swedish family with familial Alzheimer's disease, leads to increased beta-secretase cleavage of the mutant substrate. Here we describe a membrane-bound enzyme activity that cleaves full-length APP at the beta-secretase cleavage site, and find it to be the predominant beta-cleavage activity in human brain. We have purified this enzyme activity to homogeneity from human brain using a new substrate analogue inhibitor of the enzyme activity, and show that the purified enzyme has all the properties predicted for beta-secretase. Cloning and expression of the enzyme reveals that human brain beta-secretase is a new membrane-bound aspartic proteinase.     

一种新型的无搜索求解策略

提出一种基于模糊逻辑和神经网络的专家系统，它是一种集信息表达，生成与求解为一体的新型求解系。本系统的核心－学习推理网，网络的知识表达是分布的，可实现并行推理，不需要进行搜索和匹配。     

苦物质引起去甲肾上腺素预收缩的大鼠主动脉平滑肌舒张的作用机理研究

为研究苦物质舒张预收缩的大鼠胸主动脉平滑肌的作用机制,以测定肌张力为主要手段,结合多种细胞信号通路阻断剂研究了苦物质的作用通路.结果表明:苦物质对于去甲肾上腺素介导的大鼠胸主动脉的收缩具有高效、快速的舒张作用,此舒张作用与IP3受体和L型钙通道的阻断密切相关.故以氯喹和苦精为代表的苦物质因对血管平滑肌具有良好的舒张作用,有望成为针对高血压等血管相关疾病的新的治疗药物.     

一种确定转瓶中昆虫细胞摄氧率的简便方法

提出一种确定转瓶中昆虫细胞摄氧率（ＯＵＲ）的简便方法。不同溶氧水平的转瓶实验表明：在考虑了小型培养装置中溶氧解吸过程的这种方法不仅能正确反映细胞ＯＵＲ的变化状况，而且能借助ＯＵＲ迅速判断培养细胞所处生理状态。     

不锈钢罩和石英缝管增强火焰原子吸收分析灵敏度的研究

研究了用不锈钢罩和石英缝菅增强火焰原子吸收测定金属元素灵敏度的条件。结果表明,不锈钢罩和石英缝管使常规火焰法的分析灵敏度提高3～9倍,精密度得到改善,应用于GSD水系沉积物中Pb和尿中Cu等的测定,获得满意的结果。     

ZDDP润滑铜摩擦副表面膜的机制

运用摩擦学实验与表面分析相结合的方法,考察了以二烷基二硫代磷酸锌（ＺＤＤＰ）润滑的铜摩擦副表面膜,分析了表面膜中主要元素的存在状态和ＺＤＤＰ的减摩抗磨作用机制．研究结果表明：ＺＤＤＰ在铜摩擦副表面形成了由有机化合物和无机化合物共存的反应膜,该膜具有良好的减摩抗磨性能,可有效减小摩擦磨损;此外,ＺＤＤＰ还可通过对摩擦副表面的改性,增强其减摩抗磨性能     

图形文件几何参数的抽取技术

阐述了从图形文件抽取几何参数的技术，即把复杂的内部图形文件转换成外部可读的通用文件．通过对通用文件的结构分析，找出其内在的规律，然后用高级语言进行抽取和加工，将用户所需的几何参数写人数据文件，提供给用户读写，从而达到对图形数据管理的目标．