广义极值回归模型下现状数据的贝叶斯估计

广义极值分布自提出以来就受到众多学者关注,它可以用于拟合某些寿命数据,在医学、 工程和气象等领域应用很广泛.本文主要在区间删失I型数据,即现状数据下研究三参数广义极值模型的贝叶斯回归分析.基于广义极值分布的位置参数引入协变量,建立位置参数与生存时间的贝叶斯回归模型,并采用Gibbs抽样和MH算法相结合的MCMC方法,从...     

地面不均匀沉降下埋地管道响应数值分析

地面不均匀沉降会使埋地管道的受力状态发生变化,也是埋地管道遭受破坏而引发各类事故的重要原因.针对4种不同管材的管道建立了管道?土体一体化模型,采用有限元分析软件ABAQUS进行分析.对于钢管和PE管所代表的整体式管道主要分析其管道应力和应变响应,而对于球墨铸铁管和灰口铸铁管所代表的承插式管道主要分析其接口变形情况.探究...     

组织支持感对高校科技人员创新行为的影响 ——心理资本的中介作用

基于社会交换理论和积极心理学理论整合的视角,收集217份湖北高校科技人员的调查问卷,运用SPSS及结构方程模型探讨心理资本视域下组织支持感对高校科技人员创新行为的作用机制.研究表明:组织支持感中利益关心维度直接影响高校科技人员的创新行为;工作支持和价值认同两个维度通过自我效能和希望间接影响高校科技人员的创新行为,心理资...     

复合齿轮泵的几何流量特性

简介了复合齿轮泵结构原理并约定了有关概念;根据齿轮泵流量特性与啮合点位移基础理论,分析了中心轮和惰轮齿数特性对复合齿轮泵诸啮合点及位移影响;进一步分四种情况研究了啮合点运动规律和泵的流量特性,推导了流量脉动率公式,得出有关结论,供进一步研究参考     

Prevention of cisplatin-induced ototoxicity by the inhibition of gap junctional intercellular communication in auditory cells

Cis-diamminedichloroplatinum (cisplatin) is an effective chemotherapeutic drug for cancer therapy. However, most patients treated with cisplatin are at a high risk of ototoxicity, which causes severe hearing loss. Inspired by the “Good Samaritan effect” or “bystander effect” from gap junction coupling, we investigated the role of gap junctions in cisplatin-induced ototoxicity as a potential therapeutic method. We showed that connexin 43 (Cx43) was highly expressed in House Ear Institute-Organ of Corti 1 (HEI-OC1) cells, mediating cell–cell communication. The viability of HEI-OC1 cells was greatly decreased by cisplatin treatment, and cisplatin-treated HEI-OC1 cells showed lower Cx43 expression compared to that of untreated HEI-OC1 cells. In particular, high accumulation of Cx43 was observed around the nucleus of cisplatin-treated cells, whereas scattered punctuate expression of Cx43 was observed in the cytoplasm and membrane in normal cells, suggesting that cisplatin may interrupt the normal gap junction communication by inhibiting the trafficking of Cx43 to cell membranes in HEI-OC1 cells. Interestingly, we found that the inhibition of gap junction activity reduced cisplatin-induced apoptosis of auditory hair cells. Cx43 siRNA- or 18α-GA-treated HEI-OC1 cells showed higher cell viability compared to control HEI-OC1 cells during cisplatin treatment; this was also supported by fluorescence recovery after photobleaching studies. Inhibition of gap junction activity reduced recovery of calcein acetoxymethyl ester fluorescence compared to control cells. Additionally, analysis of the mechanisms involved demonstrated that highly activate extracellular signal-regulated kinase and protein kinase B, combined with inhibition of gap junctions may promote cell viability during cisplatin treatment.     

努力推进以社会主义核心价值体系为基础的企业文化建设

文章就如何树立社会主义和新价值体系,推进企业文化建设进行了简要阐述.     

平幅退浆联合机现场总线控制系统的同步控制

在介绍平幅退浆联合机系统的基础上,以三种智能点为基础,给出了平幅退浆现场癖线控制系统的硬件设计,论述了平幅奶浆联合机同步反馈装置松紧架原理,给出了联合机同步控制原理以及实现主,工讨论了工程实现中应注意的问题和解决办法,这些在实际运行中得到的正确的验证。     

高等级公路桥面防水层的分类和施工控制要点

介绍了高速公路常用的几种桥面防水层类型和使用效果,并提出了桥面防水层施工的控制要点,桥面防水层的材料选择和施工质量对桥面铺装使用寿命的影响也作了说明。     

美国图书馆“制造空间”的本土化透视——图书馆空间服务

通过对美国图书馆"制造空间"这种图书馆学新发展模式的本土化透视,揭示了图书馆发展模式的转变,即通过图书馆的多样化服务,让读者真正融入图书馆中,由提供"服务"转变为提供"空间",从提供资源转变为帮助创新,改变传统的升级服务的图书馆发展模式。     

正交结构的Fe_3B电子理论

应用键距差方法分析了o-Fe3B的价电子结构，指出了o-Fe3B的价电子结构的基本特点，并以此为基础分析了o-Fe3B的某些物理性质．