Fibulin-2 is involved in early extracellular matrix development of the outgrowing mouse mammary epithelium

Cell–matrix interactions control outgrowth of mammary epithelium during puberty and pregnancy. We demonstrate here that the glycoprotein fibulin-2 (FBLN2) is strongly associated with pubertal and early pregnant mouse mammary epithelial outgrowth. FBLN2 was specifically localized to the cap cells of the terminal end buds during puberty and to myoepithelial cells during very early pregnancy (days 2–3) even before morphological changes to the epithelium become microscopically visible, but was down-regulated thereafter. Exposure to exogenous oestrogen (E2) or E2 plus progesterone (P) increased Fbln2 mRNA expression in the pubertal gland, indicating hormonal control. FBLN2 was co-expressed and co-localised with the proteoglycan versican (VCAN) and co-localised with laminin (LN), while over-expression of FBLN2 in HC-11 cells increased cell adhesion to several extracellular matrix proteins including LN and fibronectin, but not collagens. Mammary glands from Fbln2 knockout mice showed no obvious phenotype but increased fibulin-1 (FBLN1) staining was detected, suggesting a compensatory mechanism by other fibulin family members. We hypothesise that similar to embryonic aortic smooth muscle development, FBLN2 and VCAN expression alters the cell–matrix interaction to allow mammary ductal outgrowth and development during puberty and to enable epithelial budding during pregnancy.     

基于CPFR的协同补货方法

针对传统的供应链需求预测模型中信息结构呈分散状态、对各成员预测结构差别大、影响库存补充策略的问题,创新地将CPFR技术应用到了协同补货的方法研究中,建立了基于最佳库存和最佳运送周期之间的函数关系的数学模型,并在此基础上采用进化策略法对建立的模型求解.结果表明,随着各项参数值的提高,总成本也随之增加,即最佳运输周期与最佳库存量受各项参数值的影响,其结论也验证了此方法的有效性.     

基于BERT的数控机床故障领域命名实体识别

针对数控机床(computer numerical control,CNC)故障领域命名实体识别方法中存在实体规范不足及有效实体识别模型缺乏等问题,制定了领域内实体标注策略,提出了一种基于双向转换编码器(bidirectional encoder representations from transformers,BERT)的数控机床故障领域命名实体识别方法。采用BERT编码层预训练,将生成向量输入到双向长短期记忆网络(bidirectional long short-term memory,BiLSTM)交互层以提取上下文特征,最终通过条件随机域(conditional random field,CRF)推理层输出预测标签。实验结果表明,BERT-BiLSTM-CRF模型在数控机床故障领域更具优势,与现有模型相比,F1值提升大于1.85%。     

降雨影响下紧邻桥梁软土基坑围护结构受力变形研究

某基坑受连续降雨影响,基坑围护结构及其紧邻桥梁桩基受力变形影响较大,施工安全风险大增。为此,本文基于饱和与非饱和土体强度参数变化规律和线性内插法对坑内土体力学参数进行计算,结合现场实测数据,采用有限元模拟分析了坑内降水及开挖所引起的围护结构受力变形规律及紧邻桥梁桩基变形规律,并探讨了降雨时长对基坑围护结构变形影响。结果表明,基坑开挖至坑底,围护结构发生“踢脚”大变形,易引起第一道混凝土支撑受拉脱落,最大水平位移发生在围护结构底部;桥梁桩基减弱了因开挖引起的基坑周围土体滑移,造成围护结构两侧受力不对称,导致其远离桩基侧变形过大;降雨引起坑内部分土体软化,使得围护结构水平位移进一步增大;在基坑非饱和区范围内且降雨强度一定时,围护结构水平位移量随降雨时长呈非线性加速增长趋势。     

Evaluating Volume Fractions of the Elements for Composite Laminates by Using Dielectric Properties

A series and parallel model for investigating the capacity of composite laminates and the relationship between the dielectric properties of the composites and its constituents are presented. Volume fractions of the constituents are considered in this study. The expression of the complex dielectric constants for evaluating volume fractions under discrete frequencies is established and the general solutions for the resultant linear simultaneous equations for system are also exploited. The results show that the high accuracy of proposed method is obtained.     

电液比例径向柱塞泵负载敏感变量控制特性的仿真

分析了电液比例控制负载敏感变量径向柱塞泵的工作原理 ,利用功率键合图建立了变量控制系统的数学方程式 ,以Matlab下的Simulink建立出系统各元件的仿真模型 .针对泵的变量实验结果得到的曲线 ,应用Simulink进行仿真 .通过对该系统的仿真 ,可以清楚地观察到泵的变量控制系统的工作过程和变化状态 ,为各种控制系统的设计提供了简单、方便、实用的计算机辅助设计方法 .     

不同磷营养水平对重金属Cu、Zn、Cd生物毒性效应的影响

运用水溞趋光行为的抑制试验,研究了水体中不同磷营养水平和重金属（Cu、Zn、Cd）共同存在时的联合生物毒性效应.结果表明,在较低浓度下,水体中无机磷的生物毒性很小;当浓度较高时,不同形态的无机磷对水溞生物毒性存在显著差异,大小顺序为：PO4^3-〉H2PO4-≈HPO4^2-.在富营养化的水体中,重金属的生物毒性与水体中磷的营养水平有关,磷的存在可一定程度地减轻重金属污染的生物毒害作用.研究结果可为进一步了解富营养化状态下的重金属毒性变化以及富营养化和重金属污染的相互关系及生态毒性效应提供理论依据,为淡水资源的保护及水生生态系统的健康质量评价和恢复提供理论依据和手段.     

钾细菌在我国农业生产上的应用

本文分析了钾细菌作为生物肥料施用后对粮食作物、经济作物、蔬菜和果树的增产效果,简述了增产原因,明确指出钾细菌肥在建立生态农业,生产绿色食品中的作用和意义,应大力推广应用。     

输运层对双层器件电致发光效率的影响

建立了双层器件载流子输运与复合发光的多势垒的理论模型,用以描述高场下载流子输运与复合发光的机理,并详细讨论了输运层势垒及外加电压对器件复合效率的影响.结果表明:双层器件的发光是载流子隧穿内界面后在两有机层(输运层)中的复合发光,输运层的势垒宽度和高度对器件发光效率的影响很大,且阴极区(阳极区)的势垒宽度双势垒高度对其影响更大;同时也可看到电场对复合区域具有调制作用.