Fibulin-2 is involved in early extracellular matrix development of the outgrowing mouse mammary epithelium

Cell–matrix interactions control outgrowth of mammary epithelium during puberty and pregnancy. We demonstrate here that the glycoprotein fibulin-2 (FBLN2) is strongly associated with pubertal and early pregnant mouse mammary epithelial outgrowth. FBLN2 was specifically localized to the cap cells of the terminal end buds during puberty and to myoepithelial cells during very early pregnancy (days 2–3) even before morphological changes to the epithelium become microscopically visible, but was down-regulated thereafter. Exposure to exogenous oestrogen (E2) or E2 plus progesterone (P) increased Fbln2 mRNA expression in the pubertal gland, indicating hormonal control. FBLN2 was co-expressed and co-localised with the proteoglycan versican (VCAN) and co-localised with laminin (LN), while over-expression of FBLN2 in HC-11 cells increased cell adhesion to several extracellular matrix proteins including LN and fibronectin, but not collagens. Mammary glands from Fbln2 knockout mice showed no obvious phenotype but increased fibulin-1 (FBLN1) staining was detected, suggesting a compensatory mechanism by other fibulin family members. We hypothesise that similar to embryonic aortic smooth muscle development, FBLN2 and VCAN expression alters the cell–matrix interaction to allow mammary ductal outgrowth and development during puberty and to enable epithelial budding during pregnancy.     

基于CPFR的协同补货方法

针对传统的供应链需求预测模型中信息结构呈分散状态、对各成员预测结构差别大、影响库存补充策略的问题,创新地将CPFR技术应用到了协同补货的方法研究中,建立了基于最佳库存和最佳运送周期之间的函数关系的数学模型,并在此基础上采用进化策略法对建立的模型求解.结果表明,随着各项参数值的提高,总成本也随之增加,即最佳运输周期与最佳库存量受各项参数值的影响,其结论也验证了此方法的有效性.     

基于BERT的数控机床故障领域命名实体识别

针对数控机床(computer numerical control,CNC)故障领域命名实体识别方法中存在实体规范不足及有效实体识别模型缺乏等问题,制定了领域内实体标注策略,提出了一种基于双向转换编码器(bidirectional encoder representations from transformers,BERT)的数控机床故障领域命名实体识别方法。采用BERT编码层预训练,将生成向量输入到双向长短期记忆网络(bidirectional long short-term memory,BiLSTM)交互层以提取上下文特征,最终通过条件随机域(conditional random field,CRF)推理层输出预测标签。实验结果表明,BERT-BiLSTM-CRF模型在数控机床故障领域更具优势,与现有模型相比,F1值提升大于1.85%。     

降雨影响下紧邻桥梁软土基坑围护结构受力变形研究

某基坑受连续降雨影响,基坑围护结构及其紧邻桥梁桩基受力变形影响较大,施工安全风险大增。为此,本文基于饱和与非饱和土体强度参数变化规律和线性内插法对坑内土体力学参数进行计算,结合现场实测数据,采用有限元模拟分析了坑内降水及开挖所引起的围护结构受力变形规律及紧邻桥梁桩基变形规律,并探讨了降雨时长对基坑围护结构变形影响。结果表明,基坑开挖至坑底,围护结构发生“踢脚”大变形,易引起第一道混凝土支撑受拉脱落,最大水平位移发生在围护结构底部;桥梁桩基减弱了因开挖引起的基坑周围土体滑移,造成围护结构两侧受力不对称,导致其远离桩基侧变形过大;降雨引起坑内部分土体软化,使得围护结构水平位移进一步增大;在基坑非饱和区范围内且降雨强度一定时,围护结构水平位移量随降雨时长呈非线性加速增长趋势。     

锗对铁皮石斛原球茎的生长及抗氧化酶系的影响

研究了不同浓度的锗（GeO2）对组培铁皮石斛原球茎的鲜重、可溶性蛋白质、叶绿素含量以及保护酶系统（SOD,CAT,POD）活性的影响．结果表明：适宜浓度的GeO2（5．00mg／L）能够显著增加铁皮石斛原球茎的鲜重,提高可溶性蛋白质和叶绿素含量,使SOD、CAT活性明显升高,而POD的活性则呈现缓慢的下降趋势．由此可见,培养基中添加5．00mg／L的锗时,对铁皮石斛原球茎的生长是有明显促进作用的．     

沸石的复合改性及其同步脱氮除磷效果

为了解决污水处理厂后续脱氮除磷处理工艺的占地及成本问题,以廉价天然沸石为原料,制备了能够同步脱氮除磷的复合改性沸石,研究了不同制备条件对吸附效果的影响.研究结果表明,季铵盐-氯化钠复合改性沸石不仅去除氨氮,而且实现了同步去除磷和硝氮,脱氮除磷速度快,效率高,且去除互不影响;对氨氮、磷和硝氮的吸附数据均符合伪二级动力学方程.当该沸石在生活污水中的投加量为50 g/L时,实际出水水质可由一级B一步提高到一级A,对氨氮、硝氮和磷的去除率分别高达71.09%,91.18%,93.11%.吸附饱和后的沸石经单一的NaCl溶液再生后可循环使用,且再生时间短,操作简单.该复合改性沸石在实际生活污水的处理中具有良好的应用前景.     

上海精品酒店的空间分布与市场域分析

基于从Google Earth与百度地图上所采集的信息,将上海的精品酒店、五星级酒店名录、上海城区3A级以上景区景点、上海市历史文物保护单位名录等相关地址坐标输入Arc GIS软件.通过Arc GIS软件对这些单位进行准确定位,利用空间分析工具测量一些距离数据,制作精品酒店分布图、精品酒店市场域分析.     

Research on logistics domain-oriented cloud resource management model and architecture

To address the challenges posed by resource shortage or surplus to enterprises productivity,Internet platforms have been widely used,which can balance shortage and surplus in broader environments.However,the existing resource management models lack openness,sharing ability and scalability,which make it difficult for many heterogeneous resources to co-exist in the same system.It is also difficult to resolve the conflicts between distributed self-management and centralized scheduling in the system.This paper analyzes the characteristics of resources in the distributed environment and proposes a new resource management architecture by considering the resource aggregation capacity of cloud computing.The architecture includes a universal resource scheduling optimization model which has been applied successfully in double-district multi-ship-scheduling multi-container-yard empty containers transporting of international shipping logistics.Applications in all these domains prove that this new resource management architecture is feasible and can achieve the expected effect.