资本市场中的头羊-从羊模型

针对目前中国证券市场中普遍存在着个人投资者对机构投资者的羊群行为这一特殊现象 ,建立了一个头羊 -从羊模型 .通过一定的参数假设和计算 ,定量地指出这种羊群行为增加了资产价格的波动 ,并且在大多数情况下头羊的收益大于从羊的收益 .但是随着头羊数量的增加和头羊收到的信息中的噪声增加 ,头羊 -从羊的收益之差减少 .最后从模型结论引申出稳定市场、改善市场结构、增加信息效率的建议.     

基于Extend的大型露天矿卡车调度系统仿真

在分析大型露天矿卡车调度系统的基础上，以Extend为平台，对露天矿卡车调度系统进行了动态仿真设计，提出了大型露天矿卡车调度系统仿真建模的新方法，具体描述了仿真建模的思路和过程。同时，提出了评价露天矿卡车调度系统的三个重要的性能指标并将其应用于系统仿真，仿真结果验证了仿真系统的合理性、正确性。     

基于有向循环图的多学科设计优化模型调度方法

复杂产品的多学科设计优化过程中，往往会涉及到不同学科的专业分析模型以及各种商业软件应用的集成调度运行问题。在多学科设计优化过程中模型应用集成的基础上，结合设计模型的调度需求，研究了多学科模型的调度运行，并给出了基于有向循环图的通用模型调度解决方案，包括回路探测算法和模型调度算法。最后设计并实现了支持复杂产品多学科设计优化软件框架——iDesign的调度引擎，并以一个设计模型的调度为例，验证了方法的正确性和可行性。     

上海建设海上人工岛及长江口亚三角洲体系的战略意义

近代上海的崛起,依靠的是地处我国弓箭型江海格局关节点的独特区位优势.在上海发展的历史轨迹中,有三个重要的交汇点:即苏州河与黄浦江、黄浦江与长江、长江与东海的汇合处.在第一个交汇点上,形成了以外滩为标志的近代繁华;在第二个交汇点处,包括宝钢、外高桥以及浦东新区,带动了上海改革开放30年的蓬勃发展;而第三个交汇点,就是浩瀚的长江口.     

Mutations in CTC1, encoding conserved telomere maintenance component 1, cause Coats plus

Coats plus is a highly pleiotropic disorder particularly affecting the eye, brain, bone and gastrointestinal tract. Here, we show that Coats plus results from mutations in CTC1, encoding conserved telomere maintenance component 1, a member of the mammalian homolog of the yeast heterotrimeric CST telomeric capping complex. Consistent with the observation of shortened telomeres in an Arabidopsis CTC1 mutant and the phenotypic overlap of Coats plus with the telomeric maintenance disorders comprising dyskeratosis congenita, we observed shortened telomeres in three individuals with Coats plus and an increase in spontaneous γH2AX-positive cells in cell lines derived from two affected individuals. CTC1 is also a subunit of the α-accessory factor (AAF) complex, stimulating the activity of DNA polymerase-α primase, the only enzyme known to initiate DNA replication in eukaryotic cells. Thus, CTC1 may have a function in DNA metabolism that is necessary for but not specific to telomeric integrity.     

Mutations in the gene encoding filamin B disrupt vertebral segmentation, joint formation and skeletogenesis

The filamins are cytoplasmic proteins that regulate the structure and activity of the cytoskeleton by cross-linking actin into three-dimensional networks, linking the cell membrane to the cytoskeleton and serving as scaffolds on which intracellular signaling and protein trafficking pathways are organized (reviewed in refs. 1,2). We identified mutations in the gene encoding filamin B in four human skeletal disorders. We found homozygosity or compound heterozygosity with respect to stop-codon mutations in autosomal recessive spondylocarpotarsal syndrome (SCT, OMIM 272460) and missense mutations in individuals with autosomal dominant Larsen syndrome (OMIM 150250) and the perinatal lethal atelosteogenesis I and III phenotypes (AOI, OMIM 108720; AOIII, OMIM 108721). We found that filamin B is expressed in human growth plate chondrocytes and in the developing vertebral bodies in the mouse. These data indicate an unexpected role in vertebral segmentation, joint formation and endochondral ossification for this ubiquitously expressed cytoskeletal protein.     

A complementary transposon tool kit for Drosophila melanogaster using P and piggyBac

With the availability of complete genome sequence for Drosophila melanogaster, one of the next strategic goals for fly researchers is a complete gene knockout collection. The P-element transposon, the workhorse of D. melanogaster molecular genetics, has a pronounced nonrandom insertion spectrum. It has been estimated that 87% saturation of the approximately 13,500-gene complement of D. melanogaster might require generating and analyzing up to 150,000 insertions. We describe specific improvements to the lepidopteran transposon piggyBac and the P element that enabled us to tag and disrupt genes in D. melanogaster more efficiently. We generated over 29,000 inserts resulting in 53% gene saturation and a more diverse collection of phenotypically stronger insertional alleles. We found that piggyBac has distinct global and local gene-tagging behavior from that of P elements. Notably, piggyBac excisions from the germ line are nearly always precise, piggyBac does not share chromosomal hotspots associated with P and piggyBac is more effective at gene disruption because it lacks the P bias for insertion in 5' regulatory sequences.     

Localized mutations in the gene encoding the cytoskeletal protein filamin A cause diverse malformations in humans

Remodeling of the cytoskeleton is central to the modulation of cell shape and migration. Filamin A, encoded by the gene FLNA, is a widely expressed protein that regulates re-organization of the actin cytoskeleton by interacting with integrins, transmembrane receptor complexes and second messengers. We identified localized mutations in FLNA that conserve the reading frame and lead to a broad range of congenital malformations, affecting craniofacial structures, skeleton, brain, viscera and urogenital tract, in four X-linked human disorders: otopalatodigital syndrome types 1 (OPD1; OMIM 311300) and 2 (OPD2; OMIM 304120), frontometaphyseal dysplasia (FMD; OMIM 305620) and Melnick-Needles syndrome (MNS; OMIM 309350). Several mutations are recurrent, and all are clustered into four regions of the gene: the actin-binding domain and rod domain repeats 3, 10 and 14/15. Our findings contrast with previous observations that loss of function of FLNA is embryonic lethal in males but manifests in females as a localized neuronal migration disorder, called periventricular nodular heterotopia (PVNH; refs. 3-6). The patterns of mutation, X-chromosome inactivation and phenotypic manifestations in the newly described mutations indicate that they have gain-of-function effects, implicating filamin A in signaling pathways that mediate organogenesis in multiple systems during embryonic development.     

用遗传算法直接搜索证券组合投资的有效边界

基于遗传算法，提出了一种全球新的直接搜索证券组合投资有效边界的方法，相比于Markowitz方法，它不需要计算协方差矩阵，而且能够适应更复杂的情况，最后，应用上证30指数股票对该算法进行了实证检验，结果良好。