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排序方式: 共有164条查询结果,搜索用时 31 毫秒
141.
Mapping photonic entanglement into and out of a quantum memory 总被引:2,自引:0,他引:2
Developments in quantum information science rely critically on entanglement-a fundamental aspect of quantum mechanics that causes parts of a composite system to show correlations stronger than can be explained classically. In particular, scalable quantum networks require the capability to create, store and distribute entanglement among distant matter nodes by means of photonic channels. Atomic ensembles can play the role of such nodes. So far, in the photon-counting regime, heralded entanglement between atomic ensembles has been successfully demonstrated through probabilistic protocols. But an inherent drawback of this approach is the compromise between the amount of entanglement and its preparation probability, leading to intrinsically low count rates for high entanglement. Here we report a protocol where entanglement between two atomic ensembles is created by coherent mapping of an entangled state of light. By splitting a single photon and performing subsequent state transfer, we separate the generation of entanglement and its storage. After a programmable delay, the stored entanglement is mapped back into photonic modes with overall efficiency of 17%. Together with improvements in single-photon sources, our protocol will allow 'on-demand' entanglement of atomic ensembles, a powerful resource for quantum information science. 相似文献
142.
Calcium signalling in astrocytes couples changes in neural activity to alterations in cerebral blood flow by eliciting vasoconstriction or vasodilation of arterioles. However, the mechanism for how these opposite astrocyte influences provide appropriate changes in vessel tone within an environment that has dynamic metabolic requirements remains unclear. Here we show that the ability of astrocytes to induce vasodilations over vasoconstrictions relies on the metabolic state of the rat brain tissue. When oxygen availability is lowered and astrocyte calcium concentration is elevated, astrocyte glycolysis and lactate release are maximized. External lactate attenuates transporter-mediated uptake from the extracellular space of prostaglandin E(2), leading to accumulation and subsequent vasodilation. In conditions of low oxygen concentration extracellular adenosine also increases, which blocks astrocyte-mediated constriction, facilitating dilation. These data reveal the role of metabolic substrates in regulating brain blood flow and provide a mechanism for differential astrocyte control over cerebrovascular diameter during different states of brain activation. 相似文献
143.
Numerical simulations were used to optimize the casting design and conditions for large cast iron castings for marine engines, Simulations of the mold filling and solidification sequences were used to analyze the problems of previous casting conditions with marked improvements for large cylinder liner parts, The amount and positions of chills were optimized to improve the mechanical properties and to minimize the shrinkage and micro porosity in the castings. Ultra sonic testing, penetration testing, and mechanical property testing show no defects in the castings with the productivity significantly increased. 相似文献
144.
A new multivariate stochastic volatility model is developed in this paper. The main feature of this model is to allow threshold asymmetry in a factor covariance structure. The new model provides a parsimonious characterization of volatility and correlation asymmetry in response to market news. Statistical inferences are drawn from Markov chain Monte Carlo methods. We introduce news impact analysis to analyze volatility asymmetry with a factor structure. This analysis helps us to study different responses of volatility to historical market information in a multivariate volatility framework. Our model is successful when applied to an extensive empirical study of twenty stocks. Copyright © 2009 John Wiley & Sons, Ltd. 相似文献
145.
A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis 总被引:1,自引:0,他引:1
Boström P Wu J Jedrychowski MP Korde A Ye L Lo JC Rasbach KA Boström EA Choi JH Long JZ Kajimura S Zingaretti MC Vind BF Tu H Cinti S Højlund K Gygi SP Spiegelman BM 《Nature》2012,481(7382):463-468
146.
Garnett MJ Edelman EJ Heidorn SJ Greenman CD Dastur A Lau KW Greninger P Thompson IR Luo X Soares J Liu Q Iorio F Surdez D Chen L Milano RJ Bignell GR Tam AT Davies H Stevenson JA Barthorpe S Lutz SR Kogera F Lawrence K McLaren-Douglas A Mitropoulos X Mironenko T Thi H Richardson L Zhou W Jewitt F Zhang T O'Brien P Boisvert JL Price S Hur W Yang W Deng X Butler A Choi HG Chang JW Baselga J Stamenkovic I Engelman JA Sharma SV Delattre O Saez-Rodriguez J Gray NS Settleman J Futreal PA Haber DA 《Nature》2012,483(7391):570-575
Clinical responses to anticancer therapies are often restricted to a subset of patients. In some cases, mutated cancer genes are potent biomarkers for responses to targeted agents. Here, to uncover new biomarkers of sensitivity and resistance to cancer therapeutics, we screened a panel of several hundred cancer cell lines--which represent much of the tissue-type and genetic diversity of human cancers--with 130 drugs under clinical and preclinical investigation. In aggregate, we found that mutated cancer genes were associated with cellular response to most currently available cancer drugs. Classic oncogene addiction paradigms were modified by additional tissue-specific or expression biomarkers, and some frequently mutated genes were associated with sensitivity to a broad range of therapeutic agents. Unexpected relationships were revealed, including the marked sensitivity of Ewing's sarcoma cells harbouring the EWS (also known as EWSR1)-FLI1 gene translocation to poly(ADP-ribose) polymerase (PARP) inhibitors. By linking drug activity to the functional complexity of cancer genomes, systematic pharmacogenomic profiling in cancer cell lines provides a powerful biomarker discovery platform to guide rational cancer therapeutic strategies. 相似文献
147.
Mutations in LGI1 cause autosomal-dominant partial epilepsy with auditory features. 总被引:28,自引:0,他引:28
Sergey Kalachikov Oleg Evgrafov Barbara Ross Melodie Winawer Christie Barker-Cummings Filippo Martinelli Boneschi Chang Choi Pavel Morozov Kamna Das Elita Teplitskaya Andrew Yu Eftihia Cayanis Graciela Penchaszadeh Andreas H Kottmann Timothy A Pedley W Allen Hauser Ruth Ottman T Conrad Gilliam 《Nature genetics》2002,30(3):335-341
The epilepsies are a common, clinically heterogeneous group of disorders defined by recurrent unprovoked seizures. Here we describe identification of the causative gene in autosomal-dominant partial epilepsy with auditory features (ADPEAF, MIM 600512), a rare form of idiopathic lateral temporal lobe epilepsy characterized by partial seizures with auditory disturbances. We constructed a complete, 4.2-Mb physical map across the genetically implicated disease-gene region, identified 28 putative genes (Fig. 1) and resequenced all or part of 21 genes before identifying presumptive mutations in one copy of the leucine-rich, glioma-inactivated 1 gene (LGI1) in each of five families with ADPEAF. Previous studies have indicated that loss of both copies of LGI1 promotes glial tumor progression. We show that the expression pattern of mouse Lgi1 is predominantly neuronal and is consistent with the anatomic regions involved in temporal lobe epilepsy. Discovery of LGI1 as a cause of ADPEAF suggests new avenues for research on pathogenic mechanisms of idiopathic epilepsies. 相似文献
148.
The mean sea surface heights (sea surface topography) of the South China, East China, Yellow and Bohai Seas are derived from
an ocean general circulation model and surface air pressure. The circulation model covers the global oceans, with fine grid
(1/6°) covering the East Asian marginal seas and coarse grid (3°) covering the rest part of the global oceans. The result
shows that the China 1985 National Altitude Datum is 24.7 cm above the mean sea surface height of the world oceans. The mean
sea surface in the coastal ocean adjacent to China is higher in the south than in the north. Intercomparison of the model
results with the geodetic leveling measurements at 28 coastal tidal stations shows a standard deviation of 4.8 cm and a fitting
coefficient of 95.3%. After correction through linear regression, the standard deviation is reduced to 4.5 cm. This indicates
that the accuracy of model results is sufficient for practical application. Based on the model results, the mean sea surface
heights for the study area with a resolution of 1/6 degree are given. This result also links the mean sea levels at islands
with those on the mainland coast and gives the mean sea surface heights at tidal stations in the Taiwan Island, the Dongsha
Islands, the Xisha Islands and the Nansha Islands relative to the China 1985 National Altitude Datum. 相似文献
149.
YANGJia-long WANGFu ZUOLiang YIGu-chul CHOIWong-yong 《武汉大学学报:自然科学英文版》2005,10(3):581-586
Silicon ( 111 ) and Silicon (100) have been employed for fabrication of TiO2 films by metal organic chemical vapor deposition (MOCVD). Titanium (Ⅳ) isopropoxide (Ti[O (C3H7)4 ])was used as a precursor. The as-deposited TiO2 films have been characterized with Field emission scanning electron microscopy (FE-SEM), X ray diffraction (XRD) and atomic force microscopy (AFM). The photocatalytic properties were investigated by decomposition of aqueous orange Ⅱ. The crystalline and structural properties of TiO2 film had crucial influences on the photodegradation efficiency. For MOCVD in-situ deposited films on Si substrates, thephotoactivities varied following a shape of “M”: At lower (350 ℃ ) middle (500 ℃) and higher (800 ℃) temperature of deposition, relative lower photodegradation activities have been observed. At 400 ℃ and 700 ℃ of deposition, relative higher efficiencies of degradation have been obtained, because one predominant crystallite orientation could be obtained as deposition at those two temperatures, especially a single anatase crystalline TiO2 film could be obtained at 700 ℃ growth. 相似文献
150.
Protease nexin-II, a potent antichymotrypsin, shows identity to amyloid beta-protein precursor 总被引:20,自引:0,他引:20
W E Van Nostrand S L Wagner M Suzuki B H Choi J S Farrow J W Geddes C W Cotman D D Cunningham 《Nature》1989,341(6242):546-549
Protease nexin-II (PN-II) is a protease inhibitor that forms SDS-resistant inhibitory complexes with the epidermal growth factor (EGF)-binding protein, the gamma-subunit of nerve growth factor, and trypsin. The properties of PN-II indicate that it has a role in the regulation of certain proteases in the extracellular environment. Here we describe more of the amino-acid sequence of PN-II and its identity to the deduced sequence of the amyloid beta-protein precursor (APP). Amyloid beta-protein is present in neuritic plaques and cerebrovascular deposits in individuals with Alzheimer's disease and Down's syndrome. A monoclonal antibody against PN-II (designated mAbP2-1) recognized PN-II in immunoblots of serum-free culture medium from human glioblastoma cells and neuroblastoma cells, as well as in homogenates of normal and Alzheimer's disease brains. In addition, mAbP2-1 stained neuritic plaques in Alzheimer's disease brain. PN-II was a potent inhibitor of chymotrypsin with an inhibition constant Ki of 6 x 10(-10)M. Together, these data demonstrate that PN-II and APP are probably the same protein. The regulation of extracellular proteolysis by PN-II and the deposition of at least parts of the molecule in senile plaques is consistent with previous reports that implicate altered proteolysis in the pathogenesis of Alzheimer's disease. 相似文献