群和线性半群的准完备性

本文提出了群完备和准完备的充要条件。同时,还较详尽地讨论了线性半群中的完备性问题。定出其所有的准完备类(即极大封闭集)     

最小二乘配点法解壳体弯曲问题

本文用最小二乘配点法分析弹性壳体弯曲问题。采用了加权残数法中的混合法—事先既不满足壳体弯曲定解微分方程式亦不满足边界条件,所选试函数为文献[1]中提到的双重幂级数。对于4边简支圆柱壳,其数值计算解与经典解析解误差不超过1.5％;对于悬臂圆柱壳,取其特例一悬臂效分析时,其结果与解析解误差亦不大。用本法可以编制出壳体弯曲问题的通用计算程序。     

关于长寿命mRNA的研究 Ⅳ.在植物贮藏器官——大蒜鳞茎中发现存在长寿命mRNA

本文报导在植物贮藏器官一大蒜鳞茎中首次发现长寿命mRNA。该长寿命mRNA贮存有鳞茎萌发和幼苗早期生长所需的信息,能够转译过氧化物酶和细胞色素氧化酶同工酶。     

用积分平均法求解沸腾炉空气埋管的动态特性

本文提出了建立具有分布参数性质的沸腾炉空气埋管的数学模型的一种有效方法， 即积分加权平均、低阶集中参数法（简称积分平均法），并把这种算法与利用高阶（４９ 阶）集中参数模型所得的结果作了对比，两者重合良好．在此基础上，给出了空气埋管。 动态特性的实际算例．并由此得到了两个在控制系统设计中有价值的结论。     

Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion

Drug resistance presents a challenge to the treatment of cancer patients. Many studies have focused on cell-autonomous mechanisms of drug resistance. By contrast, we proposed that the tumour micro-environment confers innate resistance to therapy. Here we developed a co-culture system to systematically assay the ability of 23 stromal cell types to influence the innate resistance of 45 cancer cell lines to 35 anticancer drugs. We found that stroma-mediated resistance is common, particularly to targeted agents. We characterized further the stroma-mediated resistance of BRAF-mutant melanoma to RAF inhibitors because most patients with this type of cancer show some degree of innate resistance. Proteomic analysis showed that stromal cell secretion of hepatocyte growth factor (HGF) resulted in activation of the HGF receptor MET, reactivation of the mitogen-activated protein kinase (MAPK) and phosphatidylinositol-3-OH kinase (PI(3)K)-AKT signalling pathways, and immediate resistance to RAF inhibition. Immunohistochemistry experiments confirmed stromal cell expression of HGF in patients with BRAF-mutant melanoma and showed a significant correlation between HGF expression by stromal cells and innate resistance to RAF inhibitor treatment. Dual inhibition of RAF and either HGF or MET resulted in reversal of drug resistance, suggesting RAF plus HGF or MET inhibitory combination therapy as a potential therapeutic strategy for BRAF-mutant melanoma. A similar resistance mechanism was uncovered in a subset of BRAF-mutant colorectal and glioblastoma cell lines. More generally, this study indicates that the systematic dissection of interactions between tumours and their micro-environment can uncover important mechanisms underlying drug resistance.     

预报林木生长的Kalman滤波器

<正>根据林木生长的随机性和动态性,用CAR模型自动辩识机辩知林木生长“多对多”动态系统的阶、参数。然后把得到的差分方程组变换成状态矩阵方程,在此基础上对林木生长动态进行Kalman滤波和实时预报,并给出了预报精度。     

A Study of the Behaviour of Denim Cloth Made from Modified Rotor Spun Yarn

This paper described the physical behaviour of three types of denim cloths produced from rotor yarn, ring yarn and modified rotor yarn (prepared by adding conventional twist to rotor yarn) respectively. Experimental work showed that denim cloth produced from the modified rotor yarn has superior properties over conventional rotor yarn in terms of surface texture and appearance,tearing strength and resistance to abrasion.     

Observations of passenger flow and verification of a crowd dynamics model

This paper reports observations of passenger flow in the Wuchang railway station in Wuhan, China during the Chinese Traditional Spring Festival in 2006. The data collected are used to verify a crowd dynamics model previously developed. The crowd dynamics model is based on simulating the global movement of each individual under the influence of the surrounding crowd, and the good agreement between the predictions and observations validates the prediction model. The crowd dynamics model suggests that the crowd movement speed is dominated by two factors： the front-back inter-person effect, and the pedestrian＇s self-motive. The first effect gives logarithmic relationship between the crowd speed and crowd density. The second factor depends on the individual motive driven with which people try to divorce themselves from the control of the crowd movement. The prediction model are helpful to guide the design of public traffic systems for effective crowd dispersal.     

低捻转杯纺纱实验与理论分析--提高低捻转杯纱强力探索

研究在转杯纺加捻区中加装阻扭件,然后选用相同的棉条纺制不同捻系数的转杯纱(加装阻扭件和不加装阻扭件)和环锭纱,并测试其成纱的强伸性能、表面形态和扭转性能.测试结果表明,加装阻扭件的转杯纱可以适当改善转杯纺的加捻效果,进而适当提高了转杯纱的成纱强力.     

Identity of cells that imprint H-2-restricted T-cell specificity in the thymus

The thymus has two important roles in controlling the specificity of T lymphocytes. First, T cells differentiating in the thymus are rendered tolerant of 'self' antigens, particularly antigens encoded by the major histocompatibility complex, the H-2 complex in mice. Second, the thymus imbues T cells with the property of H-2-restricted recognition of antigen, that is, the capacity of T cells to react with foreign antigens presented in association with self H-2 gene products. Until recently it has generally been assumed that self-tolerance and H-2-restricted specificity both reflect early T-cell contact with self H-2 determinants expressed on thymic epithelial cells. Recent evidence suggests, however, that intrathymic cells of the macrophage/dendritic cell (Mphi/DC) lineage also have a role in shaping T-cell specificity. In particular, it has been found that the tolerance to graft-type H-2 determinants which normally ensues when T cells differentiate in an H-2-different thymus fails to occur when the thymus is pretreated with deoxyguanosine (dGuo), a procedure that selectively destroys Mphi/DC but spares epithelial cells. In contrast to these findings on tolerance induction, evidence is presented here that dGuo-treated thymus grafts do imprint T cells with H--2-restricted specificity for antigen. It appears, therefore, that induction of tolerance and H--2 restriction are controlled by different cells in the thymus.