具有非光滑Lyapunov函数控制系统的反馈控制器设计及仿真

研究了Lyapunov函数为一类非光滑函数——极大值函数时,控制系统反馈控制器设计中的数值计算问题,并给出了对系统进行分段常数反馈控制的具体实现方法和步骤。仿真实验结果表明了该控制方法的可行性和有效性。     

Ergonomic Evaluation on Taxi Drivers Compartment

Driving involves long hours of physical work within c onfined compartment. Taxi drivers usually work with prolonged working hours, add itional stress may likely be induced on particular body limbs. Occupational heal th may occur and working efficiency may potentially be affected resulting fr om fatigues, pains or diseases. These problems, however, could be remedied if mo re attention is paid on seating design, the workplace and driving postures adopt ed. Ergonomics design can provide better understanding...     

Translating insights from the cancer genome into clinical practice

Cancer cells have diverse biological capabilities that are conferred by numerous genetic aberrations and epigenetic modifications. Today's powerful technologies are enabling these changes to the genome to be catalogued in detail. Tomorrow is likely to bring a complete atlas of the reversible and irreversible alterations that occur in individual cancers. The challenge now is to work out which molecular abnormalities contribute to cancer and which are simply 'noise' at the genomic and epigenomic levels. Distinguishing between these will aid in understanding how the aberrations in a cancer cell collaborate to drive pathophysiology. Past successes in converting information from genomic discoveries into clinical tools provide valuable lessons to guide the translation of emerging insights from the genome into clinical end points that can affect the practice of cancer medicine.     

羽状流作用下的非等温空调射流运动研究

在传统非等温射流理论的基础上,考虑由室内热源形成的羽状气流对非等温空调射流的热浮升作用,建立数学模型,得到了在内热源作用下非等温射流运动轨迹方程表达式。同时对不同热源形式、热源大小以及热源位置对空调射流和室内热舒适性的影响进行了实验研究,并根据实验结果对热源与射流的相互作用进行了讨论。结果表明,室内热源的存在将明显改变空调射流的运动轨迹,影响室内热舒适性。     

The clonal and mutational evolution spectrum of primary triple-negative breast cancers

Primary triple-negative breast cancers (TNBCs), a tumour type defined by lack of oestrogen receptor, progesterone receptor and ERBB2 gene amplification, represent approximately 16% of all breast cancers. Here we show in 104 TNBC cases that at the time of diagnosis these cancers exhibit a wide and continuous spectrum of genomic evolution, with some having only a handful of coding somatic aberrations in a few pathways, whereas others contain hundreds of coding somatic mutations. High-throughput RNA sequencing (RNA-seq) revealed that only approximately 36% of mutations are expressed. Using deep re-sequencing measurements of allelic abundance for 2,414 somatic mutations, we determine for the first time-to our knowledge-in an epithelial tumour subtype, the relative abundance of clonal frequencies among cases representative of the population. We show that TNBCs vary widely in their clonal frequencies at the time of diagnosis, with the basal subtype of TNBC showing more variation than non-basal TNBC. Although p53 (also known as TP53), PIK3CA and PTEN somatic mutations seem to be clonally dominant compared to other genes, in some tumours their clonal frequencies are incompatible with founder status. Mutations in cytoskeletal, cell shape and motility proteins occurred at lower clonal frequencies, suggesting that they occurred later during tumour progression. Taken together, our results show that understanding the biology and therapeutic responses of patients with TNBC will require the determination of individual tumour clonal genotypes.     

关于半单优BCI-代数

本文将讨论半单优BCI-代数的性质。我们得到了如下主要的结果: (1) 一个非零优BCI-代数X是半单的充要条件是X为单理想的次直积。 (2) 设X是一个非零半单优BCI-代数,则如下命题是等价的: ⅰ,X可写成有限个单理想的次直积。ⅱ,X是Noether的。ⅲ,X是Artin的。     

Gene rearrangement in cells with natural killer activity and expression of the beta-chain of the T-cell antigen receptor

The mammalian host defence system can be divided broadly into adaptive and non-adaptive immunity. Adaptive immunity is acquired and is mediated by B and T lymphocytes. Non-adaptive immunity is mediated in part by a small subclass of heterogeneous peripheral blood mononuclear cells. This population, termed null cells, consists of haematopoietic precursors and cells mediating natural killer (NK) activity and antibody-dependent cellular cytotoxicity (ADCC). NK cells are a class of non-adherent, non-phagocytic, rapidly cytotoxic lymphocytes which can efficiently lyse a wide variety of tumour cells, virally infected cells and immature cell types of normal origin. Despite the broad range of targets, only a limited number of specificities are thought to be involved in target-cell recognition. Morphologically, NK cells are large granular lymphocytes, but they have been shown to exhibit cell-surface markers characteristic of both T cells and monocytes, raising doubt over their lineage. The recent cloning of the beta-chain of the T-cell antigen receptor has now allowed us to investigate whether some NK cells are T-cell-related. We have examined rearrangement and expression of the beta-chain of the T-cell receptor in cloned murine NK cell lines and fresh murine NK cell populations, and our results support the hypothesis that a subpopulation of NK cells is related to T cells and provide basis for examining whether some NK activity is mediated by a small number of T-cell receptors.     

A new insight into combining forecasts for elections: The role of social media

This study is devoted to gain insight into a timely, accurate, and relevant combining forecast by considering social media (Facebook), opinion polls, and prediction markets. We transformed each type of raw data into the possibility of victory as a forecasting model. Besides the four single forecasts, namely Facebook fans, Facebook “people talking about this” (PTAT) statistics, opinion polls, and prediction markets, we generated three combined forecasts by associating various combinations of the four components. Then, we examined the predictive performance of each forecast on vote shares and the elected/non‐elected outcome across the election period. Our findings, based on the evidence of Taiwan's 2018 county and city elections, showed that incorporating the Facebook PTAT statistic with polls and prediction markets generates the most powerful forecast. Moreover, we recognized the matter of the time horizons where the best proposed model has better accuracy gains in prediction—in the “late of election,” but not in “approaching election”. The patterns of the trend of accuracy across time for each forecasting model also differ from one another. We also highlighted the complementarity of various types of data in the paper because each forecast makes important contributions to forecasting elections.