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排序方式: 共有150条查询结果,搜索用时 31 毫秒
71.
谐波对平均值原理仪表测量的影响分析 总被引:1,自引:0,他引:1
非线性负载的广泛应用,导致电力系统中的谐波日益严重.电力系统中使用的交流电压表和电流表通常采用整流式仪表,其工作原理是对电网电压和电流的平均值响应,利用平均值和有效值的比例关系从而得出信号的有效值.由于是按50 Hz标准正弦波设计,当电网电压中有高次谐波或者负荷电流中有高次谐波时,必然会影响其正常工作.因此采用平均值原理的仪表测量非正弦周期信号电压和电流的有效值,存在原理性的误差.基于其工作原理,定量分析不同谐波下的误差及一定谐波含量下误差的大小.通过分析结果,建议采用真有效值原理的电压表和电流表. 相似文献
72.
C G Mathew K S Chin D F Easton K Thorpe C Carter G I Liou S L Fong C D Bridges H Haak A C Kruseman 《Nature》1987,328(6130):527-528
Multiple endocrine neoplasia type 2A (MEN2A) is an autosomal dominantly inherited cancer syndrome characterized by medullary carcinoma of the thyroid, phaeochromocytoma and hyperparathyroidism. Almost all gene carriers can be detected by screening tests before the age of 40, but the nature and location of the predisposing gene are unknown. Simpson et al. recently reported preliminary evidence for linkage between the DNA probe p9-12A on chromosome 10 and MEN2A. We now report linkage between the MEN2A locus and the interstitial retinol-binding protein gene, which is located on chromosome 10p11.2-q11.2. 相似文献
73.
Urease. 8. Its interaction with sodium dodecyl sulfate 总被引:1,自引:0,他引:1
74.
本文证明了公式β(n)=σ(n-1)+1其中α(n-1)是n-1次多项式微分系统的不为直线的最多条数,βn)是n次多项式微分系统的不变直线的不同斜率的最大个数。这里假设所讨论的多项式系统只有限条不变直线。 相似文献
75.
Inhibition of thyroid hormone action by a non-hormone binding c-erbA protein generated by alternative mRNA splicing 总被引:38,自引:0,他引:38
R J Koenig M A Lazar R A Hodin G A Brent P R Larsen W W Chin D D Moore 《Nature》1989,337(6208):659-661
76.
中国共产党提出了构建和谐社会的新理念,把和谐社会的建设同经济建设、政治建设、文化建设有力地结合起来,形成了构建和谐社会的合力论思想。构建社会主义和谐社会,必须坚持马克思主义关于历史发展的合力论思想,即“促正”、“纠反”,构建和谐社会,并构建由四大合力机制组成的合力机制体系。 相似文献
77.
Biological functions of the ING family tumor suppressors 总被引:11,自引:0,他引:11
78.
Maser RS Choudhury B Campbell PJ Feng B Wong KK Protopopov A O'Neil J Gutierrez A Ivanova E Perna I Lin E Mani V Jiang S McNamara K Zaghlul S Edkins S Stevens C Brennan C Martin ES Wiedemeyer R Kabbarah O Nogueira C Histen G Aster J Mansour M Duke V Foroni L Fielding AK Goldstone AH Rowe JM Wang YA Look AT Stratton MR Chin L Futreal PA DePinho RA 《Nature》2007,447(7147):966-971
Highly rearranged and mutated cancer genomes present major challenges in the identification of pathogenetic events driving the neoplastic transformation process. Here we engineered lymphoma-prone mice with chromosomal instability to assess the usefulness of mouse models in cancer gene discovery and the extent of cross-species overlap in cancer-associated copy number aberrations. Along with targeted re-sequencing, our comparative oncogenomic studies identified FBXW7 and PTEN to be commonly deleted both in murine lymphomas and in human T-cell acute lymphoblastic leukaemia/lymphoma (T-ALL). The murine cancers acquire widespread recurrent amplifications and deletions targeting loci syntenic to those not only in human T-ALL but also in diverse human haematopoietic, mesenchymal and epithelial tumours. These results indicate that murine and human tumours experience common biological processes driven by orthologous genetic events in their malignant evolution. The highly concordant nature of genomic events encourages the use of genomically unstable murine cancer models in the discovery of biological driver events in the human oncogenome. 相似文献
79.
Molecular recognition is the key step in a wide range of controlled separation and chemical transformation processes, with enzymes performing this task with an unsurpassed degree of selectivity. Enzymes contain only 20 simple amino acids, yet it remains difficult to rationalize or even predict these stereospecific recognition events. Nonetheless, the rational design of receptors able to recognize amino acids stereospecifically is attracting considerable interest because therapeutic drugs, that may be developed from chiral amino acid intermediates, are increasingly required in enantiomerically pure form. Early work has stimulated the development of efficient receptors based on small molecules, but binding of amino acids with high and predictable stereospecificity remains difficult to achieve. Directed molecular evolution, on the other hand, does select for RNA sequences or antibodies that bind amino acids with high specificity, but typically without providing insights into the molecular recognition mechanisms involved. Here we show that a rationally designed metal complex formed from a trivalent cobalt ion and a tetradentate ligand binds natural amino acids, including the simple yet challenging amino acid alanine, with high and predictable regio- and stereospecificity. We expect that our approach will allow the binding as well as separation and stereospecific catalytic formation of its target amino acids. 相似文献
80.
Zang ZJ Cutcutache I Poon SL Zhang SL McPherson JR Tao J Rajasegaran V Heng HL Deng N Gan A Lim KH Ong CK Huang D Chin SY Tan IB Ng CC Yu W Wu Y Lee M Wu J Poh D Wan WK Rha SY So J Salto-Tellez M Yeoh KG Wong WK Zhu YJ Futreal PA Pang B Ruan Y Hillmer AM Bertrand D Nagarajan N Rozen S Teh BT Tan P 《Nature genetics》2012,44(5):570-574
Gastric cancer is a major cause of global cancer mortality. We surveyed the spectrum of somatic alterations in gastric cancer by sequencing the exomes of 15 gastric adenocarcinomas and their matched normal DNAs. Frequently mutated genes in the adenocarcinomas included TP53 (11/15 tumors), PIK3CA (3/15) and ARID1A (3/15). Cell adhesion was the most enriched biological pathway among the frequently mutated genes. A prevalence screening confirmed mutations in FAT4, a cadherin family gene, in 5% of gastric cancers (6/110) and FAT4 genomic deletions in 4% (3/83) of gastric tumors. Frequent mutations in chromatin remodeling genes (ARID1A, MLL3 and MLL) also occurred in 47% of the gastric cancers. We detected ARID1A mutations in 8% of tumors (9/110), which were associated with concurrent PIK3CA mutations and microsatellite instability. In functional assays, we observed both FAT4 and ARID1A to exert tumor-suppressor activity. Somatic inactivation of FAT4 and ARID1A may thus be key tumorigenic events in a subset of gastric cancers. 相似文献