乙醇HCCI燃烧化学反应动力学模型的建立

根据乙醇燃烧化学动力学机理和热力学数据.并利用实验数据进行了对比,为实验研究提供了重要的、有价值的参考.     

Bcl-2和Caspase-3在HT诱导的HL-60细胞凋亡中的作用

利用常规的HL－60细胞和转染了 bcl－2基因的HL－60/Bcl-2细胞及转染了空载体的对照HL－60／neo细胞为模型,研究Caspase-3及过表达的Bcl-2对凋亡过程中的各种生化,形态学特征的影响,探讨了Caspase-3及Bcl-2在三尖杉酯碱（HT）诱导的HL－60细胞凋亡中的作用,研究表明,Caspase-3的湃化在HT诱导的HL－60细胞凋亡中处于关键地位,导致了质膜出泡,PS翻转,染色质凝集,DNA断裂及凋亡下游的发生,而Bcl-2则通过抑制aspase-3的活化抑制了凋亡的发生,同时还证明,在HT诱导的HL－60细胞凋亡中,通常被认为是凋亡早期特征的磷脂酰丝氨酸PS翻转并不是一个早期特征,它至少晚于Caspase-3的活化,甚至不早于质膜出泡及染色质凝集。     

TLP张力腿涡激非线性响应

对张力腿平台（简称TLP）的张力腿提出了一种新的数学模型,并在波浪,水流共同作用下对张力腿的横向涡激振动进行了研究,通过实例计算了发生谐持时的响应,同时讨论了应用伽辽金法的项数对精确度的影响,所得结果具有重要的参考价值。     

温室温湿度遗传模糊神经网络控制仿真研究

利用模糊神经网络对温室夏季温湿度控制进行了仿真研究 ,同时为了克服BP算法收敛速度慢和局部极小这两大弱点 ,采用改进的遗传算法对网络的参数进行训练 ,从而为将模糊逻辑、神经网络、遗传算法三者有机地结合起来应用于温室环境控制的可行性提供了理论依据     

混沌理论与分形理论在热工过程中的应用

通过介绍混沌和分形 ,找出它们的内在联系和共同的本质。用混沌理论和分形理论来描述和解决热工———工艺过程与动力学系统中的数学建模和一些实际问题 ,说明了系统中的每个领域可能有无数个奇异吸引子 ,其奇异吸引子的作用就是一个混合过程。最后 ,作为分形的应用 ,分析了热混合层中温度脉动的分形特征 ,在一定尺度范围内表现出很好的分形特性。     

中国西北半干旱区弃耕地植被恢复技术的研究--Ⅰ.弃耕地补播技术研究

通过对中国西北半干旱区弃耕地恢复技术的研究,筛选出适宜于西北半干旱区弃耕地植被恢复应用的优良草种,补播时间及补播机具,总结出西北弃耕地植被恢复的关键技术.     

Association analyses identify six new psoriasis susceptibility loci in the Chinese population

We extended our previous genome-wide association study for psoriasis with a multistage replication study including 8,312 individuals with psoriasis (cases) and 12,919 controls from China as well as 3,293 cases and 4,188 controls from Germany and the United States and 254 nuclear families from the United States. We identified six new susceptibility loci associated with psoriasis in the Chinese study containing the candidate genes ERAP1, PTTG1, CSMD1, GJB2, SERPINB8 and ZNF816A (combined P < 5 × 10??) and replicated one locus, 5q33.1 (TNIP1-ANXA6), previously reported (combined P = 3.8 × 10?21) in the European studies. Two of these loci showed evidence for association in the German study at ZNF816A and GJB2 with P = 3.6 × 10?3 and P = 7.9 × 10?3, respectively. ERAP1 and ZNF816A were associated with type 1 (early onset) psoriasis in the Chinese Han population (test for heterogeneity P = 6.5 × 10?3 and P = 1.5 × 10?3, respectively). Comparisons with the results of previous GWAS of psoriasis highlight the heterogeneity of disease susceptibility between the Chinese and European populations. Our study identifies new genetic susceptibility factors and suggests new biological pathways in psoriasis.     

利率波动对股票价格影响的实证研究

就利率如何影响股票价格进行了理论分析,并利用上海证券交易所7天国债回购利率与上证指数数据进行了实证研究,发现中国的股票价格与利率之间存在共同的长期趋势,利率的目度波动领先股票目收益率的变动。对此现象．给出了一些相应的经济解释和政策建议。     

The reproductive strategies of clausiliid land snails from Northern Vietnam (Gastropoda: Stylommatophora)

Under laboratory conditions we scrutinized the reproduction and development of two clausiliid land snail species from northern Vietnam: Phaedusa paviei (Morlet, 1892) and Oospira vanbuensis (Bavay and Dautzenberg, 1899). These species, very similar in shell size and shape, feature different reproductive modes. The former is viviparous, giving birth to one or two neonates on a single occasion, with the number of developing embryos retained in the reproductive tract ranging from 1 to 11. The embryonic shells are 1.8–4.7 mm in height. The latter species is oviparous and produces eggs in clutches (four to six per clutch). Hatching occurs 18–21 days after egg-laying. Both species exhibit a similar growth pattern: the ultimate shell size is attained after 6.5–8.5 months and reproduction starts 5–7 months later. The distribution of viviparous reproduction among the Phaedusinae and its taxonomic importance are discussed.     

Serine protease PRSS55 is crucial for male mouse fertility via affecting sperm migration and sperm–egg binding

Testis-specific PRSS55 is a highly conserved chymotrypsin-like serine protease among mammalian species. So far, the physiological function of PRSS55 remains unknown. Here, we show that PRSS55 is a GPI-anchored membrane protein, specifically expressed in adult mouse testis and mainly observed in the luminal side of seminiferous tubules and sperm acrosome. Mice deficient for Prss55 develop male infertile with normal reproduction-related parameters observed. Interestingly, in vivo fertilization rate of Prss55^?/? males is dramatically decreased, possibly due to incapable migration of Prss55^?/? sperm from uterus into oviduct. However, in vitro fertilization rate has no difference between two genotypes although Prss55^?/? sperm presents defective recognition/binding to zona-intact or zona-free oocytes. Further study reveals that mature ADAM3 is almost undetectable in Prss55^?/? sperm, while precursor ADAM3 remains unchanged in the testis. However, it is shown that ADAM3 has no interaction with PRSS55 by immunoprecipitation with anti-PRSS55 antibody. The expression levels of several proteins known to be related to the observed phenotypes remain comparable between wt and Prss55^?/? mice. Moreover, we found that Prss55 deficiency has no effect on PRSS37 or vice versa albeit two mutant males share almost the same phenotypes. Microarray analysis reveals a total of 72 differentially expressed genes in Prss55^?/? testis, most of which are associated with cellular membrane and organelle organization, protein transport and complex assembly, and response to stimulus and signaling. In conclusion, we have demonstrated that PRSS55 plays vital roles in regulating male fertility of mice, including in vivo sperm migration and in vitro sperm–egg interaction, possibly by affecting the maturation of ADAM3 in sperm and the expression of multiple genes in testis.