全文获取类型
收费全文 | 78篇 |
免费 | 2篇 |
国内免费 | 2篇 |
专业分类
系统科学 | 1篇 |
理论与方法论 | 1篇 |
现状及发展 | 23篇 |
研究方法 | 16篇 |
综合类 | 41篇 |
出版年
2020年 | 1篇 |
2018年 | 2篇 |
2015年 | 1篇 |
2014年 | 2篇 |
2012年 | 6篇 |
2011年 | 12篇 |
2009年 | 4篇 |
2008年 | 4篇 |
2007年 | 4篇 |
2006年 | 3篇 |
2005年 | 4篇 |
2004年 | 5篇 |
2003年 | 2篇 |
2002年 | 3篇 |
2001年 | 5篇 |
1999年 | 3篇 |
1995年 | 2篇 |
1994年 | 1篇 |
1987年 | 1篇 |
1985年 | 2篇 |
1981年 | 2篇 |
1979年 | 4篇 |
1977年 | 2篇 |
1976年 | 2篇 |
1975年 | 1篇 |
1973年 | 2篇 |
1967年 | 1篇 |
1965年 | 1篇 |
排序方式: 共有82条查询结果,搜索用时 15 毫秒
31.
32.
Wu C Miao X Huang L Che X Jiang G Yu D Yang X Cao G Hu Z Zhou Y Zuo C Wang C Zhang X Zhou Y Yu X Dai W Li Z Shen H Liu L Chen Y Zhang S Wang X Zhai K Chang J Liu Y Sun M Cao W Gao J Ma Y Zheng X Cheung ST Jia Y Xu J Tan W Zhao P Wu T Wang C Lin D 《Nature genetics》2012,44(1):62-66
Pancreatic cancer has the lowest survival rate among human cancers, and there are no effective markers for its screening and early diagnosis. To identify genetic susceptibility markers for this cancer, we carried out a genome-wide association study on 981 individuals with pancreatic cancer (cases) and 1,991 cancer-free controls of Chinese descent using 666,141 autosomal SNPs. Promising associations were replicated in an additional 2,603 pancreatic cancer cases and 2,877 controls recruited from 25 hospitals in 16 provinces or cities in China. We identified five new susceptibility loci at chromosomes 21q21.3, 5p13.1, 21q22.3, 22q13.32 and 10q26.11 (P = 2.24 × 10(-13) to P = 4.18 × 10(-10)) in addition to 13q22.1 previously reported in populations of European ancestry. These results advance our understanding of the development of pancreatic cancer and highlight potential targets for the prevention or treatment of this cancer. 相似文献
33.
34.
He L Zhang Z Yu Y Ahmed S Cheung NS Qi RZ 《Cellular and molecular life sciences : CMLS》2011,68(9):1633-1643
The neuronal Cdk5 activator p35 is involved in a multitude of neuronal activities, including cytoskeletal organization. We
show here that p35 directly interacts with filamentous actin (F-actin) but not with monomeric actin (G-actin). Through binding,
p35 induces the formation of actin bundles and stabilizes F-actin against dilution-induced depolymerization. p35 forms intermolecular
self-associations, suggesting that p35 cross-links actin filaments into bundles via its intermolecular self-association. p35
dimerization and association with F-actin occur at the N-terminal region that is absent in the calpain-cleaved product p25,
indicating that such p35 properties are lost by its truncation induced under neurotoxic conditions. Using p35 phosphorylated
by Cdk5 and a mutational approach, we demonstrate that the phosphorylation of p35 promotes its homodimerization and p35-induced
formation of F-actin bundles. In addition, the phosphorylation regulates p35 distribution to microtubule and actin cytoskeletons.
Together, these observations define a novel function for p35 in cytoskeletal regulation. 相似文献
35.
36.
37.
Summary -L-aspartyl-L-alanine, a dipeptide found in the brain, increases the amplitude of the miniature endplate potentials (MEPPs) in phrenic nerve-diaphragm preparations from rats. The peptide also stimulates the appearance of a population of giant MEPPs.This work was supported by NSF grant BNS 79-00352 and NIH grant CA-27031 to R. Lim. 相似文献
38.
S. H. Chung J. C. Hwang Y. S. Chan Y. M. Cheung K. B. Fung 《Cellular and molecular life sciences : CMLS》1979,35(2):216-217
Summary A simple, low cost interspike interval analyzer for the analysis of trains of nerve impulses is described. The analyzer is built with readily available integrated circuits and has been used to analyze spike trains in the lateral vestibular nucleus of cats.Acknowledgment. This research is supported in part by Higher Degrees and Research Grant No. 158/363 to J.C.H. from the University of Hong Kong. 相似文献
39.
MCALONAN Grainne M YU Kevin K CHAN Raymond C K CHUA Siew E CHEUNG Charlton 《科学通报(英文版)》2011,56(32):3376-3381
The term "neurodevelopmental disorder" broadly encompasses conditions thought to arise early in development and includes schizophrenia, bipolar disorder and autism among others. These conditions share a number of genetic and environmental risk factors postulated to lead to common difficulties in socio-emotional processing, communication and cognitive function. The alternative position is that, while the same traits are affected across these conditions, the nature or direction in which they are modified may be distinct. MRI studies provide a rapidly expanding and rich database which we propose can be used to contribute to this debate. Anatomical likelihood estimation (ALE) is a method of meta-analysis applied to voxel-based MRI studies. We have adapted this method to explore the extent to which schizophrenia and bipolar disorder and schizophrenia and autism share a common brain structural phenotype. We will review this work here and discuss whether there is sufficient other evidence to justify a common framework for further research into the inter-relatedness of such conditions. 相似文献
40.
Hydroxyproline-rich glycoproteins in plant reproductive tissues: structure, functions and regulation 总被引:10,自引:0,他引:10
H. Wu B. de Graaf C. Mariani A.Y. Cheung 《Cellular and molecular life sciences : CMLS》2001,58(10):1418-1429
The plant reproductive process of pollination involves a series of interactions between the male gametophyte (the pollen
grain or pollen tube) and extracellular matrix (ECM) molecules secreted by different cell types along the pollen tube growth
pathway in the female organ, the pistil. These interactions are believed to signal and regulate the pollen tube growth process
to effect successful delivery of the sperm cells to the ovules where fertilization takes place. Hydroxyproline-rich glycoproteins
secreted by plant cells are believed to play a broad range of functions, ranging from providing structural integrity to mediating
cell-cell interactions and communication. The pistil and pollen tube ECM is enriched in these highly glycosylated proteins.
Our discussions here will focus on a number of these proteins for which most information has been available, from Nicotiana tabacum, its self-incompatible relative N. alata, and Zea mays. In addition, the regulation of the synthesis and glyco-modification of one of these proteins, TTS (transmitting tissue-specific)
protein from N. tabacum will be discussed in the light of how differential glycosylation may be used to regulate molecular interactions within the
ECM. 相似文献