A genome-wide association study in Han Chinese identifies new susceptibility loci for ankylosing spondylitis

To identify susceptibility loci for ankylosing spondylitis, we performed a two-stage genome-wide association study in Han Chinese. In the discovery stage, we analyzed 1,356,350 autosomal SNPs in 1,837 individuals with ankylosing spondylitis and 4,231 controls; in the validation stage, we analyzed 30 suggestive SNPs in an additional 2,100 affected individuals and 3,496 controls. We identified two new susceptibility loci between EDIL3 and HAPLN1 at 5q14.3 (rs4552569; P = 8.77 × 10(-10)) and within ANO6 at 12q12 (rs17095830; P = 1.63 × 10(-8)). We also confirmed previously reported associations in Europeans within the major histocompatibility complex (MHC) region (top SNP, rs13202464; P < 5 × 10(-324)) and at 2p15 (rs10865331; P = 1.98 × 10(-8)). We show that rs13202464 within the MHC region mainly represents the risk effect of HLA-B*27 variants (including HLA-B*2704, HLA-B*2705 and HLA-B*2715) in Chinese. The two newly discovered loci implicate genes related to bone formation and cartilage development, suggesting their potential involvement in the etiology of ankylosing spondylitis.     

Hybrid particle swarm optimization for multiobjective resource allocation

Resource allocation （RA） is the problem of allocating resources among various artifacts or business units to meet one or more expected goals, such a.s maximizing the profits, minimizing the costs, or achieving the best qualities. A complex multiobjective RA is addressed, and a multiobjective mathematical model is used to find solutions efficiently. Then, all improved particie swarm algorithm （mO_PSO） is proposed combined with a new particle diversity controller policies and dissipation operation. Meanwhile, a modified Pareto methods used in PSO to deal with multiobjectives optimization is presented. The effectiveness of the provided algorithm is validated by its application to some illustrative example dealing with multiobjective RA problems and with the comparative experiment with other algorithm.     

"大系统"理论及其在温室系统建模中的应用

在简介现代系统工程发展的基础上,引入了“大系统”的基本概念,综述了“大系统”理论的特征,分类和大系统的控制邮将“大系统”理论应用到温室系统建立综合动态仿真模型中的思路,最后对建模方法进行了探讨。     

多措并举促进电力企业安全管理

电力安全生产关系到国家的财产安全、人民生活利益和电力职工的安康,是电力企业最根本的效益所在.电力安全生产是电力企业生存和发展的基石,影响着电力企业本身的内外形象,在我国经济社会正处于高速发展的大好时期,电力生产安全管理显得尤为重要.     

A combination of leaf rust resistance gene Lr34 and lesion mimic gene lm significantly enhances adult plant resistance to Puccinia triticina in wheat

Leaf rust caused by Puccinia triticina is an economically-important disease in wheat worldwide.A combination of different types of resistance genes may significantly enhance rust resistance under rust-favorable conditions.To investigate the interactions between the rust resistance gene Lr34 and the lesion mimic gene lm on 1BL in Ning 7840,a segregating F8-10 population of 180 recombinant inbred lines was developed from Ning 7840/Chokwang and evaluated for both lesion mimic expression and leaf rust response at the adult plant stage in a greenhouse.A major quantitative trait locus(QTL),derived from Sumai 3,was co-localized with Lr34 on chromosome 7D and explained 41.5% of phenotypic variations for rust severity and 22.1% for leaf tip necrosis(LTN).The presence of Lr34 was confirmed by Lr34-specific markers cssfr1 and cssfr2 in Ning 7840 and Sumai 3.Unlike Lr34,lm conditioned a spontaneous lesion mimic phenotype and had a significant effect on reducing uredinial size,and a smaller effect on severity.Additive effects were observed between lm and Lr34 for severity and LTN,and an epistatic effect was observed for infection type.Single marker analysis also identified several other QTL with minor effects on severity,infection type,or LTN.     

大口径塑料管的性能及应用概述

文章对各种大口径塑料管道的发展动态、种类、工艺性能、特点及应用进行了分析和探讨.     

Medical entity and attributes extraction system based on relation annotation

The abundant entities and entity-attribute relations in medical websites are important data resources for medical research. However, the medical websites are usually characterized of storing entity and attribute values in different pages. To extract those data records efficiently, we propose an automatic extraction system which is related to entity and attribute relations (attributes and values) of separate storage. Our system includes following modules: (1) rich-information interactive annotation page rendering; (2) separate storage attribute relations annotating; (3) annotated relations for pattern generating and data records extracting. This paper presents the relations about the attributes which are stored in many pages by effective annotation, then generates rules for data records extraction. The experiments show that the system can not only complete attribute relations of separate storage extraction, but also be compatible with regular relation extraction, while maintaining high accuracy.     

综合集成方法与专家挖掘

我们面临的一些科学和实际问题越来越复杂需要运用各种知识的综合和技术的集成,其中知识的综合尤其是将专家的活的经验和智慧挖出来更是人们所关注的.数据挖掘、文本挖掘和网上挖掘能依靠计算机和一些人工智能方法可以从大量数据、文本和网上信息中找出一些有用的规则和知识,但是对于样本较少、知识隐含的活的专家经验如何去挖掘就是专家挖掘要研究的内容.作者及其同事们在近10年的研究中形成了一些概念、方法,并在一些社会问题、中医专家经验传承等进行了应用和探索.     

尖端创新神经技术脑研究计划:美国脑研究计划评介

正作为神经科学研究超级大国的美国,正拟启动尖端创新神经技术脑研究计划。该计划此前称作脑活动图计划,已经过一年多的筹备性论证。计划的主要目标是,通过包括纳米技术在内的一系列技术创新,全面构造神经活动图谱,以求在神经-精神疾病诊治及智能机开发上取得突破。围绕计划目标之可行性存在大量争鸣。     

周期可调谐金属光栅的制备工艺研究

介绍了一种制备金属可调谐光栅的新技术。首先采用紫外光刻技术将光栅结构制作至PDMS（聚二甲基硅氧烷）基底，并在其上蒸镀金属Cr层和Ag层，然后采取金属举离工艺得到金属光栅。利用PDMS高弹性的特点，通过控制PDMS纵、横向拉伸程度，对金属光栅周期进行连续、任意调谐，获得预定的目标周期。实验结果表明，金属光栅调谐范围超过其初始周期的100%。