The research of controller area network on hybrid electrical vehicle

It is of increasing importance to design and implement vehicle networks for transferring information between electrical control units on Hybrid Electrical Vehicle （HEV）. This paper presents a scheme of using Controller Area Network （CAN） technology to realize communication and datasharing between the electrical units on the HEV. The principle and communication protocol of Electrical Control Units （ECU） CAN node are introduced. By considering different sensitivity of the devices to the latency of data transportation, a new design procedure is proposed for the purpose of simplifying network codes and wiring harness, reducing assembly space and weight, improving assembly efficiency, and enhancing fault-diagnose in auto networks.     

微波等离子体法制备纳米钼粉

阐述用微波等离子法制备纳米金属钼粉的原理,探讨了此法制备纳米钼粉颗粒的工艺与影响因素,并以羰基钼为原料制得纳米级钼粉,平均粒径小于５０ｎｍ,还研究了钼粉在空气中的热稳定性。     

板式换热器中蒸汽凝结换热特性

在板式换热器的蒸汽凝结换热试验台上进行了实验研究,获取蒸汽完全凝结和部分凝结两种典型工况下的换热和压降特性．且就板式换热器中蒸汽凝结过程的换热进行分析和处理,得到了一个在板片槽道中蒸汽凝结换热系数关联式．并推荐用于板式换热器的蒸汽凝结换热系数的计算．     

Effects of electromagnetic field and lubricate condition on the surface quality of magnesium alloy billet during LFEC processing

The microstructures of the magnesium billets could be improved markedly by low-frequency electromagnetic casting(LFEC)processing.In fact,the low-frequency electromagnetic field(LFEF)also has favorite effect on the surface quality of billet.However,few public reports on the surface quality of LFEC magnesium billets could be found.Therefore,a new crystallizer with a metal internal sleeve together with a kind of lubricant was designed aiming at lowing surface turning quantity,and the effects of casting velocit...     

External synchronization of two dynamical systems with uncertain parameters

External synchronization is addressed as two or more dynamical systems with synchronous motions, which is also regarded as master-slave system. In this paper, two dynamical systems, one employs a hysteretic term to model the friction phenomenon, the other involves a hardening stiffness component with the third order of displacement due to flexible deformation, are controlled to converge to the same trajectory. The control strategy is extended from feedback control for all parameters known to adaptive contro...     

商用车驱动桥壳的疲劳分析

运用CATIA建立某型商用车驱动桥壳的实体模型,利用Hypermesh划分网格,参照标准QC—T533规定的台架试验方法,对桥壳进行弯曲刚度、垂直静强度有限元仿真计算。通过量化分析应力集中、尺寸及表面加工情况等疲劳影响因素,引入疲劳寿命仿真分析。依据QC．T534规定的评价方法,桥壳上述指标均符合国家标准,仿真结果与试验结果一致。同时指出桥壳存在问题,为下一步优化指明方向。     

Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits

We present an approximate conditional and joint association analysis that can use summary-level statistics from a meta-analysis of genome-wide association studies (GWAS) and estimated linkage disequilibrium (LD) from a reference sample with individual-level genotype data. Using this method, we analyzed meta-analysis summary data from the GIANT Consortium for height and body mass index (BMI), with the LD structure estimated from genotype data in two independent cohorts. We identified 36 loci with multiple associated variants for height (38 leading and 49 additional SNPs, 87 in total) via a genome-wide SNP selection procedure. The 49 new SNPs explain approximately 1.3% of variance, nearly doubling the heritability explained at the 36 loci. We did not find any locus showing multiple associated SNPs for BMI. The method we present is computationally fast and is also applicable to case-control data, which we demonstrate in an example from meta-analysis of type 2 diabetes by the DIAGRAM Consortium.     

Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs

Schizophrenia is a complex disorder caused by both genetic and environmental factors. Using 9,087 affected individuals, 12,171 controls and 915,354 imputed SNPs from the Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium (PGC-SCZ), we estimate that 23% (s.e. = 1%) of variation in liability to schizophrenia is captured by SNPs. We show that a substantial proportion of this variation must be the result of common causal variants, that the variance explained by each chromosome is linearly related to its length (r = 0.89, P = 2.6 × 10(-8)), that the genetic basis of schizophrenia is the same in males and females, and that a disproportionate proportion of variation is attributable to a set of 2,725 genes expressed in the central nervous system (CNS; P = 7.6 × 10(-8)). These results are consistent with a polygenic genetic architecture and imply more individual SNP associations will be detected for this disease as sample size increases.     

Evidence of widespread selection on standing variation in Europe at height-associated SNPs

Strong signatures of positive selection at newly arising genetic variants are well documented in humans, but this form of selection may not be widespread in recent human evolution. Because many human traits are highly polygenic and partly determined by common, ancient genetic variation, an alternative model for rapid genetic adaptation has been proposed: weak selection acting on many pre-existing (standing) genetic variants, or polygenic adaptation. By studying height, a classic polygenic trait, we demonstrate the first human signature of widespread selection on standing variation. We show that frequencies of alleles associated with increased height, both at known loci and genome wide, are systematically elevated in Northern Europeans compared with Southern Europeans (P < 4.3 × 10(-4)). This pattern mirrors intra-European height differences and is not confounded by ancestry or other ascertainment biases. The systematic frequency differences are consistent with the presence of widespread weak selection (selection coefficients ～10(-3)-10(-5) per allele) rather than genetic drift alone (P < 10(-15)).     

Mutations in NMNAT1 cause Leber congenital amaurosis and identify a new disease pathway for retinal degeneration

Leber congenital amaurosis (LCA) is a blinding retinal disease that presents within the first year after birth. Using exome sequencing, we identified mutations in the nicotinamide adenine dinucleotide (NAD) synthase gene NMNAT1 encoding nicotinamide mononucleotide adenylyltransferase 1 in eight families with LCA, including the family in which LCA was originally linked to the LCA9 locus. Notably, all individuals with NMNAT1 mutations also have macular colobomas, which are severe degenerative entities of the central retina (fovea) devoid of tissue and photoreceptors. Functional assays of the proteins encoded by the mutant alleles identified in our study showed that the mutations reduce the enzymatic activity of NMNAT1 in NAD biosynthesis and affect protein folding. Of note, recent characterization of the slow Wallerian degeneration (Wld(s)) mouse model, in which prolonged axonal survival after injury is observed, identified NMNAT1 as a neuroprotective protein when ectopically expressed. Our findings identify a new disease mechanism underlying LCA and provide the first link between endogenous NMNAT1 dysfunction and a human nervous system disorder.