A natural allele of Nxf1 suppresses retrovirus insertional mutations

Endogenous retroviruses have shaped the evolution of mammalian genomes. Host genes that control the effects of retrovirus insertions are therefore of great interest. The modifier-of-vibrator-1 locus (Mvb1) controls levels of correctly processed mRNA from genes mutated by endogenous retrovirus insertions into introns, including the Pitpn(vb) tremor mutation and the Eya1(BOR) model of human branchiootorenal syndrome. Positional complementation cloning identifies Mvb1 as the nuclear export factor Nxf1, providing an unexpected link between the mRNA export receptor and pre-mRNA processing. Population structure of the suppressive allele in wild Mus musculus castaneus suggests selective advantage. A congenic Mvb1(CAST) allele is a useful tool for modifying gene expression from existing mutations and could be used to manipulate engineered mutations containing retroviral elements.     

Axisymmetric fundamental solutions for a finite layer with impeded boundaries

Axisymmetrie fundamental solutions that are applied in the consolidation calculations of a finite clay layer with impeded boundaries were derived. Laplace and Hankel integral transforms were utilized with respect to time and radial coordinates, respectively in the analysis. The derivation of fundamental solutions considers two boundary-value problems involving unit point loading and ring loading in the vertical. The solut-ions are extended to circular distributed and strip distributed normal load. The computation and analysis of set-tlements, vertical total stress and excess pore pressure in the consolidation layer subject to circular loading are presented.     

De novo deletions of SNRPN exon 1 in early human and mouse embryos result in a paternal to maternal imprint switch

Prader-Willi syndrome (PWS) is a neurogenetic disease characterized by infantile hypotonia, gonadal hypoplasia, obsessive behaviour and neonatal feeding difficulties followed by hyperphagia, leading to profound obesity. PWS is due to a lack of paternal genetic information at 15q11-q13 (ref. 2). Five imprinted, paternally expressed genes map to the PWS region, MKRN3 (ref. 3), NDN (ref. 4), NDNL1 (ref. 5), SNRPN (refs 6-8 ) and IPW (ref. 9), as well as two poorly characterized framents designated PAR-1 and PAR-5 (ref. 10). Imprinting of this region involves a bipartite 'imprinting centre' (IC), which overlaps SNRPN (refs 10,11). Deletion of the SNRPN promoter/exon 1 region (the PWS IC element) appears to impair the establishment of the paternal imprint in the male germ line and leads to PWS. Here we report a PWS family in which the father is mosaic for an IC deletion on his paternal chromosome. The deletion chromosome has acquired a maternal methylation imprint in his somatic cells. We have made identical findings in chimaeric mice generated from two independent embryonic stem (ES) cell lines harbouring a similar deletion. Our studies demonstrate that the PWS IC element is not only required for the establishment of the paternal imprint, but also for its postzygotic maintenance.     

轴承硬度与耐磨性关系的探讨

对轴承硬度与耐磨性进行检测.结果表明,轴承零件的硬度值只要控制在HRC61以上,就能保证获得良好的耐磨性.     

分布式SAR空间状态与测高基线的关联建模及误差分析

给出了测量坐标系下获得的基线矢量到分布式合成孔径雷达（SAR）测高所需基线矢量的转换公式,然后利用误差分析理论,建立了它们之间的误差传播模型,最后通过仿真,对影响分布式SAR测高基线确定精度的主要误差因素进行了详细分析。     

从无形资产受益角度透视跨国公司与东道国共赢之道

在全球化浪潮下,跨国公司不能再以殖民者的姿态为自身谋利;而东道国也不能狭隘地以保护民族产业、维护国家经济安全为由抵制跨国公司的进入。跨国公司与东道国的竞合关系,在无形资产收益上表现得愈益突出。无形资产使东道国和跨国公司双赢,持久得益。     

基于共生理论的物流金融价值增值作用分析

借用共生理论中共生介质的概念,说明物流金融在制造企业和物流企业共生关系中的介质作用,即其对两者共生关系中物质流、资金流、信息流的整合效果,说明价值增值是共生系统能量增长的一种表现形式.结合波特的价值链模型,分别论证了物流金融对制造企业和物流企业及它们所形成的共生系统的价值增值作用,阐明了价值增值主要源于风险成本的降低及新服务业务的利润增加.研究表明物流金融之于制造企业和物流企业走向对称互惠共生模式的必不可少的介质.     

苯热法合成环境催化材料纳米氮化铁(英文)

采用苯热法合成环境催化材料纳米氮化铁。在高压反应釜内,无水FeCl3与Li3N在通氮气的苯溶液和450～500℃条件下反应30h,XRD结果表明主要产物为Fe4N,晶体的平均直径约为10nm。该反应条件容易控制。     

农村法律信仰的经济分析——以四川省米易县一起民事纠纷为例

法的信仰是社会主义法得以高效运行的必要条件,本文从经济学的角度,分析了我国农村法律信仰缺失的原因,认为经济因素是影响我国农村法律信仰的重要原因,因此,要加强农村法律信仰的培植,必须一方面加强经济建设,同时还应该取消农村司法收费。     

浅析大学生反社会行为矫正机制的缺陷

在市场经济的大潮下,纷繁复杂的社会环境容易引起大学生反社会行为的产生,而我国大学生反社会行为的现行矫正机制存在着许多缺陷,主要表现为立法不完善、适用程序不规范、矫正机构不统一、矫正措施不恰当、矫正社会化程度不高等五个方面。