Finding finer functions for partially characterized proteins by protein-protein interaction networks

Based on high-throughput data, numerous algorithms have been designed to find functions of novel proteins. However, the effectiveness of such algorithms is currently limited by some fundamental factors, including (1) the low a-priori probability of novel proteins participating in a detailed function; (2) the huge false data present in high-throughput datasets; (3) the incomplete data coverage of functional classes; (4) the abundant but heterogeneous negative samples for training the algorithms; and (5) the lack of detailed functional knowledge for training algorithms. Here, for partially characterized proteins, we suggest an approach to finding their finer functions based on protein interaction sub-networks or gene expression patterns, defined in function-specific subspaces. The proposed approach can lessen the above-mentioned problems by properly defining the prediction range and functionally filtering the noisy data, and thus can efficiently find proteins’ novel functions. For thousands of yeast and human proteins partially characterized, it is able to reliably find their finer functions (e.g., the translational functions) with more than 90% precision. The predicted finer functions are highly valuable both for guiding the follow-up wet-lab validation and for providing the necessary data for training algorithms to learn other proteins.     

低热能面包的研究

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合金铸铁激光处理的探讨——Ⅱ.激光辐照工艺参数的控制

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足球裁判员控制比赛气氛的探讨

足球裁判员有效地控制比赛气氛是圆满完成裁判工作的重要课题,我们对比赛气氛的变化规律进行分析研究后,制订的控制对策与方法经临场实践取得了较好的效果.     

单片机在数控机床上的应用研究

本文研究将ＭＣＳ－５１型单片机用于普通数控机床，通过监控程序设计，进一步完善机床性能，使该系统具有显示功能，快速点动、自动四零、自动升降频率、自动换刀、自动齿隙补偿、刀具磨损补偿，暂停等多种功能．     

SYNTHESIS AND CHARACTERIZATION OF MONOVALENT AND MIXED-VALENCE COMPLEXES OF COPPER WITH 2-THIOURACIL

Five polynuclear monovalent and mixed-valence complexes of copper with 2-thiouracil were synthesized. They were characterized by the molar conductivity, electromc spectra, infrared spectroscopy, thermogravimetric and magnetic susceptibility measurements. Their coordination properties and tentative structures were discussed.