数字图像连续表示及应用

研究了离散图像的连续表示及重建问题.首先利用弦理论,给出了图像的连续表示形式,然后利用付里叶变换实现了图像连续表示及重建的快速算法,接着将它们应用于图像无级缩放、图像平滑、边缘检测、角点检测,并与传统离散图像处理方法的实验结果进行了比较.实验结果表明:利用图像连续表示方法处理离散图像可以得到不差于传统的离散图像处理方法处理的结果,此方法使离散图像的解析法处理成为可能.     

PTC124 targets genetic disorders caused by nonsense mutations

Nonsense mutations promote premature translational termination and cause anywhere from 5-70% of the individual cases of most inherited diseases. Studies on nonsense-mediated cystic fibrosis have indicated that boosting specific protein synthesis from <1% to as little as 5% of normal levels may greatly reduce the severity or eliminate the principal manifestations of disease. To address the need for a drug capable of suppressing premature termination, we identified PTC124-a new chemical entity that selectively induces ribosomal readthrough of premature but not normal termination codons. PTC124 activity, optimized using nonsense-containing reporters, promoted dystrophin production in primary muscle cells from humans and mdx mice expressing dystrophin nonsense alleles, and rescued striated muscle function in mdx mice within 2-8 weeks of drug exposure. PTC124 was well tolerated in animals at plasma exposures substantially in excess of those required for nonsense suppression. The selectivity of PTC124 for premature termination codons, its well characterized activity profile, oral bioavailability and pharmacological properties indicate that this drug may have broad clinical potential for the treatment of a large group of genetic disorders with limited or no therapeutic options.     

Nucleation and growth mechanism of ferroelectric domain-wall motion

The motion of domain walls is critical to many applications involving ferroelectric materials, such as fast high-density non-volatile random access memory. In memories of this sort, storing a data bit means increasing the size of one polar region at the expense of another, and hence the movement of a domain wall separating these regions. Experimental measurements of domain growth rates in the well-established ferroelectrics PbTiO3 and BaTiO3 have been performed, but the development of new materials has been hampered by a lack of microscopic understanding of how domain walls move. Despite some success in interpreting domain-wall motion in terms of classical nucleation and growth models, these models were formulated without insight from first-principles-based calculations, and they portray a picture of a large, triangular nucleus that leads to unrealistically large depolarization and nucleation energies. Here we use atomistic molecular dynamics and coarse-grained Monte Carlo simulations to analyse these processes, and demonstrate that the prevailing models are incorrect. Our multi-scale simulations reproduce experimental domain growth rates in PbTiO3 and reveal small, square critical nuclei with a diffuse interface. A simple analytic model is also proposed, relating bulk polarization and gradient energies to wall nucleation and growth, and thus rationalizing all experimental rate measurements in PbTiO3 and BaTiO3.     

河北省御道口牧场气候生产潜力估算

御道口牧场位于河北省围场县北部坝上地区,是河北省畜牧业生产的重要产区.根据牧场多年降水和气温等气象观测资料,同时考虑地形因素和最小面积的限制,对御道口牧场的气候生产潜力进行了估算.得出牧场的气候生产潜力在3.75～5 t·hm-2·a-1之间,牧场内适合发展人工草地的平地和缓坡(＜5°)约占总土地面积的76.5%.     

风险投资制度创新分析——基于“种子期”投资的研究

随着国际竞争的日益激烈,我国提出了建立以企业为主体的技术创新体系,并指出现阶段我国企业进行自主创新具有重要意义。创新活动具有高投入、高风险、高收益的特点,需要大量的资金支持,伴随着高新技术产业的产生而产生的风险投资可以提供这种资金支持。但是目前我国风险投资对企业"种子期"的投入不够,使我国企业自主创新能力不强,随着我国经济的发展,加强"种子期"投资不仅是我国高技术产业发展的要求也是风险投资发展到一定阶段的必然选择。因此现阶段必须从国家和风险投资企业两个层面采取措施以加强"种子期"投资。     

高校化学实验室通风系统研究

针对高校化学实验室的特点,提出化学实验室通风系统、自动控制系统、BENTAX净化系统设计方案。通过对设计方案的研究,为类似工程实践提供可参考的思路和方法。     

长大公路隧道火灾安全疏散性能化设计与分析

基于性能化防火设计方法, 分析火灾条件下长大公路隧道内人 员疏散行为的特点,给出隧道内人 员疏散的安全判据,并结合某隧道 的结构及车流特征对人员疏散过程 进行了数值模拟研究,分析隧道在 正常通车和局部行车堵塞时,不同 火源位置、横通道间距与横通道宽 度对人员疏散时间及安全状态的影 响。结果表明,与建筑内人员疏散不 同,长大公路隧道内火灾的可用安 全疏散时间(ASET)与需要的安全疏 散时间(RSET)均为沿隧道长度方向 位置的函数。隧道内人员安全疏散 的时间曲线在各横通道疏散口出现 峰值,这主要是受到横通道通行能 力的限制,各疏散口人员集聚等待 所致。当隧道发生局部堵塞时,横 通道口需要的安全疏散时间显著增 加,危险性也急剧增大。隧道内人 员疏散的性能化防火设计应综合考 虑火源位置对人员载荷及疏散口位 置可用安全疏散时间的影响。该研 究为公路隧道火灾安全疏散设施的 优化设计提供依据。     

航天医学工程理论与实践

航天医学工程是伴随着我国 近40年载人航天的发展,孕育催生的 一门新兴学科,具有特色鲜明的学科 理论体系和实践技术方法。概述了航 天医学工程的体系构成、研究内容和 学科特点。     

水压力传感器系统在河床冲刷深度 实时监控中的应用研究

阐述了桩基础范围内的河床冲刷实时监测的必要性;介绍了水压力传感器监测系统的应用、技术难 点和解决方案。通过潮位监测点的设置,有效解决了水位波动的修正问题,采用依托于基桩的单点定位埋设法 实现了传感器可靠定位和传感器信号的可靠传输,苏通大桥的工程实践表明,该方法具有实时性、连续性、长 期性和精度高的特点。根据实测结果分析了桩基础范围内河床局部冲刷的机理。