The expansion of GPCR transactivation-dependent signalling to include serine/threonine kinase receptors represents a new cell signalling frontier

G protein-coupled receptor (GPCR) signalling is mediated through transactivation-independent signalling pathways or the transactivation of protein tyrosine kinase receptors and the recently reported activation of the serine/threonine kinase receptors, most notably the transforming growth factor-β receptor family. Since the original observation of GPCR transactivation of protein tyrosine kinase receptors, there has been considerable work on the mechanism of transactivation and several pathways are prominent. These pathways include the “triple membrane bypass” pathway and the generation of reactive oxygen species. The recent recognition of GPCR transactivation of serine/threonine kinase receptors enormously broadens the GPCR signalling paradigm. It may be predicted that the transactivation of serine/threonine kinase receptors would have mechanistic similarities with transactivation of tyrosine kinase pathways; however, initial studies suggest that these two transactivation pathways are mechanistically distinct. Important questions are the relative importance of tyrosine and serine/threonine transactivation pathways, the contribution of transactivation to overall GPCR signalling, mechanisms of transactivation and the range of cell types in which this phenomenon occurs. The ultimate significance of transactivation-dependent signalling remains to be defined but it appears to be prominent and if so will represent a new cell signalling frontier.     

基于信噪比的投资组合策略研究

采用收益率的协方差矩阵的特征根刻划投资的风险;用主成分综合反映证券市场的信息;用主成分的信噪比反映投资组合的期望收益率与风险之间的均衡关系,并以此作为投资组合收益极大化的指标;得到了不同与H.Markowitz的投资组合模型,并给出了具体的投资组合策略-卖空与非卖空条件下的投资组合的比例,文章最后给出了一个实例.     

Reconsideration on Homogeneous Quadratic Riemann Boundary Value Problem

The homogeneous quadratic Riemann boundary value problem (1) with Hoelder continuous coefficients for the normal case was considered by the author in 1997. But the solutions obtained there are incomplete. Here its general method of solution is obtained.     

美国USNews学科评估指标体系的剖析及其启示

通过学科评估指标体系的比较分析与研究,阐述了评估指标体系的客观性、可行性,分析了《美国新闻与世界报道》中多元学科评估指标体系的特点及对我国大学学科评估的启示。     

如何做好桩基工程旁站监理

文章介绍了桩基工程旁站监理的过程和实效及保证监理目标实现的具体措施。     

高校开设数学实验课的探索

阐述了开设数学实验课的必要性和意义，探索了数学实验课程的教学内容、教学方法、师资队伍建设、实验室建设及其对学生学习的影响．     

Abrupt climate change：Debate or action

Global abrupt climate changes have been documented by various climate records, including ice cores, ocean sediment cores, lake sediment cores, cave deposits, loess deposits and pollen records. The climate system prefers to be in one of two stable states, i.e. interstadial or stadial conditions, but not in between. The transition between two states has an abrupt character. Abrupt climate changes are, in general, synchronous in the northern hemisphere and tropical regions. The timescale for abrupt climate changes can be as short as a decade. As the impacts may be potentially serious, we need to take actions such as reducing CO2 emissions to the atmosphere.     

多媒体数据库管理的数据表示模型与融合

通过定义角色、虚拟角色、观点和虚拟观点,解决了多媒体信息的格式不同给用户造成的使用不便,同时也较好地解决了多媒体数据融合的技术关键。角色和观点掩饰了所有由信息和日常所需的格式的复杂性,利用角色和观点来支撑多媒体对象的动态扩展,致使多媒体制造者能够很容易地在运行时延伸对象的使用。     

The Optimal Solution of the Model with Physical and Human Capital Adjustment Costs

We prove that the model with physical and human capital adjustment costs has optimal solution when the production function is increasing return and the structure of vetor fields of the model changes substantially when the prodution function from decreasing return turns to increasing return. And it is shown that the economy is improved when the coefficients of adjustment costs become small.     

基于B/S模式的水利水电工程造价管理系统研究

提出了基于B／S模式的水利水电工程造价管理系统，对B／S的体系结构、系统的总体结构设计、功能及功能设计进行了阐述，并说明了系统实现的关键技术．