A new intracellular medium for prolonged viability of noradrenergic storage vesicles from rat brain

Summary The biochemical lifetime of noradrenergic storage vesicles from rat brain is greatly extended in a medium based upon the membrane impermeable anion D-tartrate. Examination of the MgATP-dependent accumulation of (–)-³H-norepinephrine suggests that this medium may more closely approximate the intracellular environment of the storage vesicle, and may better support electrochemical gradients existing across the vesicle membrane.Acknowledgments. This work was supported by grant NS 15374 (NIH) of the United States Public Heath Service.     

Effect of acetylsalicylic acid on iron absorption in the rat

Summary The in vivo administration of⁵⁹Fe to the rat accompanied by acetylsalicylic acid (ASA) enhanced significantly counts in blood, spleen, liver and femur without affecting those of the intestine. The results suggest that ASA augments iron absorption either via an inhibitory action on the synthesis of prostaglandins or by a purely chemical mechanism.This work was supported by Grant No. 6638 from CONICET (Argentina).The technical assistance of Mrs María E. Castro and Mrs Patricia Dubra is gratefully acknowledged.     

Comparison of the localization of several muscle proteins in relaxed and contracted myofibrils.

The localization of several muscle proteins in relaxed and contracted myofibrils is compared. The morphology of the myofibrils and the behavior of these proteins was also investigated under extraction conditions.     

Effect of alcohol ingestion on the epithelial cell population in rat small intestine

Summary Chronic administration of alcohol to well-nourished rats led to striking changes in the small intestinal cell population. The present experiments corroborate the view that alcohol is directly toxic to the small intestine.The authors wish to thank Mr.P. R. Gaspar for the technical assistance.     

Does nitrogen mustard mimic the X-ray effects in any case?

Résumé Les effets de l'ypérite nitrée sur le cerveau et yeux de l'embryon du rat blanc ont été analysés. Seulement les embryons présentant un aspect normal ont été coupés et colorés. De larges centres de nécrose ont été trouvés sur les coupes tandis que les «rosettes» n'ont pas pu être décelées.Bien que connue comme radiomimétique, l'yperite nitrée ne mime pas les rayons X en ce qui concerne la formation des «rosettes» dans le cerveau.