全文获取类型
收费全文 | 73篇 |
免费 | 0篇 |
专业分类
系统科学 | 2篇 |
现状及发展 | 47篇 |
研究方法 | 10篇 |
综合类 | 14篇 |
出版年
2018年 | 1篇 |
2016年 | 1篇 |
2012年 | 3篇 |
2011年 | 2篇 |
2010年 | 1篇 |
2008年 | 3篇 |
2007年 | 3篇 |
2004年 | 1篇 |
2003年 | 2篇 |
2002年 | 2篇 |
2001年 | 4篇 |
2000年 | 1篇 |
1999年 | 1篇 |
1991年 | 2篇 |
1990年 | 2篇 |
1989年 | 1篇 |
1985年 | 1篇 |
1984年 | 1篇 |
1982年 | 2篇 |
1981年 | 1篇 |
1980年 | 1篇 |
1978年 | 6篇 |
1977年 | 1篇 |
1976年 | 2篇 |
1975年 | 2篇 |
1974年 | 1篇 |
1973年 | 2篇 |
1972年 | 2篇 |
1971年 | 1篇 |
1970年 | 3篇 |
1969年 | 1篇 |
1968年 | 1篇 |
1967年 | 2篇 |
1966年 | 7篇 |
1965年 | 3篇 |
1963年 | 1篇 |
1962年 | 1篇 |
1954年 | 1篇 |
排序方式: 共有73条查询结果,搜索用时 0 毫秒
1.
Résumé Les auteurs complètent leurs recherches sur la localisation cytochimique de l'activité de la déshydrogénase succinique dans les nucléoles en utilisant un troisième sel de tetrozolium, MTT d'une importance particulière. 相似文献
2.
3.
Removal of the cell surface sialic acid with neuraminidase brings about cell deformation in amoeba. The membranes of these deformed cells are eventually ruptured leading to the liberation of the cell mass. 相似文献
4.
S. Deb S. Som S. Basu I. B. Chatterjee 《Cellular and molecular life sciences : CMLS》1981,37(9):940-941
Summary Reactive sulfhydryl groups of major hemoglobins from guinea-pig, rat and cat reduced dehydroascorbic acid to ascorbic acid leading to formation of intrachain disulfide bonds. Hybridization experiments indicated that the reduction was carried out by thea chain of cat hemoglobin.This work was supported in part by UGC and a DST grant HCS/DST/258/76. 相似文献
5.
Zusammenfassung Adreno-Ephedrin bewirkte bei Ratten Daueröstrus und Zunahme des Gewichts der Uteri und der Nebennieren. Die Ovarien enthielten Follikel verschiedener Grösse, aber keine reifen Corpora lutea. Diese Wirkungen des Adreno-Ephedrins werden auf fettige Infiltration des Leberparenchyms zurückgeführt. 相似文献
6.
R Bassel-Duby A Jayasuriya D Chatterjee N Sonenberg J V Maizel B N Fields 《Nature》1985,315(6018):421-423
The use of modern techniques has led to new insights into the molecular mechanisms of viral pathogenesis. Although the infectious process is quite complex, it is clear that one critical stage, the interaction of viral attachment proteins with cell-surface receptors, often has a major role in determining the pattern of infection. The mammalian reoviruses have served as useful models for understanding the molecular basis of viral pathogenesis. The mammalian reovirus haemagglutinin (sigma 1 protein), which is an outer capsid protein, has been shown to be a major factor in determining virus-host cell interactions. To further our understanding of the structure and function of the haemagglutinin, we have cloned a complementary DNA copy of the reovirus type 3 S1 double-stranded RNA gene which encodes the virus haemagglutinin and have sequenced the DNA complementary to the S1 gene. Analysis of the predicted amino-acid sequence of the virus haemagglutinin has allowed us to determine that the amino-terminal portion contains an alpha-helical coiled-coil structure and that the carboxy-terminal portion contains the receptor-interacting domains. Using this information, we propose here a model of how the reovirus haemagglutinin is attached to the virus particle. 相似文献
7.
Numerous post-translational modifications of histones have been described in organisms ranging from yeast to humans. Growing evidence for dynamic regulation of these modifications, position- and modification-specific protein interactions, and biochemical crosstalk between modifications has strengthened the 'histone code' hypothesis, in which histone modifications are integral to choreographing the expression of the genome. One such modification, ubiquitylation of histone H2B (uH2B) on lysine 120 (K120) in humans, and lysine 123 in yeast, has been correlated with enhanced methylation of lysine 79 (K79) of histone H3 (refs 5-8), by K79-specific methyltransferase Dot1 (KMT4). However, the specific function of uH2B in this crosstalk pathway is not understood. Here we demonstrate, using chemically ubiquitylated H2B, a direct stimulation of hDot1L-mediated intranucleosomal methylation of H3 K79. Two traceless orthogonal expressed protein ligation (EPL) reactions were used to ubiquitylate H2B site-specifically. This strategy, using a photolytic ligation auxiliary and a desulphurization reaction, should be generally applicable to the chemical ubiquitylation of other proteins. Reconstitution of our uH2B into chemically defined nucleosomes, followed by biochemical analysis, revealed that uH2B directly activates methylation of H3 K79 by hDot1L. This effect is mediated through the catalytic domain of hDot1L, most likely through allosteric mechanisms. Furthermore, asymmetric incorporation of uH2B into dinucleosomes showed that the enhancement of methylation was limited to nucleosomes bearing uH2B. This work demonstrates a direct biochemical crosstalk between two modifications on separate histone proteins within a nucleosome. 相似文献
8.
9.
10.