嵌入式Web服务器Boa的移植及其应用

鉴于目前监控系统对实时性和多连接处理能力的要求，介绍一款单任务的嵌入式Web服务器Boa．对将Boa移植到运行uClinux操作系统的ARM微处理器平台上的过程进行了讨论，在此基础上构建了嵌入式Web服务器．为用户提供基于HTTP协议的网络接入方式，最后给出一个基于B／S模式的网络视频监控系统的实例．     

Complex reorganization and predominant non-homologous repair following chromosomal breakage in karyotypically balanced germline rearrangements and transgenic integration

We defined the genetic landscape of balanced chromosomal rearrangements at nucleotide resolution by sequencing 141 breakpoints from cytogenetically interpreted translocations and inversions. We confirm that the recently described phenomenon of 'chromothripsis' (massive chromosomal shattering and reorganization) is not unique to cancer cells but also occurs in the germline, where it can resolve to a relatively balanced state with frequent inversions. We detected a high incidence of complex rearrangements (19.2%) and substantially less reliance on microhomology (31%) than previously observed in benign copy-number variants (CNVs). We compared these results to experimentally generated DNA breakage-repair by sequencing seven transgenic animals, revealing extensive rearrangement of the transgene and host genome with similar complexity to human germline alterations. Inversion was the most common rearrangement, suggesting that a combined mechanism involving template switching and non-homologous repair mediates the formation of balanced complex rearrangements that are viable, stably replicated and transmitted unaltered to subsequent generations.     

戈壁琵甲(鞘翅目:拟步甲科)生物学特性的研究

戈壁琵甲2年发生1代，世代不整齐，以成虫和不同龄期的幼虫越冬，成虫4月上旬至9月下旬产卵，卵期为8～12d．幼虫一般为12龄．幼虫期为1～1．5a．越冬幼虫于次年6月下旬至9月上旬化蛹．蛹前期为40～45d，蛹期为12～20d．羽化成虫后经280～300d性成熟，开始交配产卵，戈壁琵甲食性杂．不喜光．活动有明显的节律性．成虫具有利用防御腺进行自卫的特性，其防御腺分泌物可成为医学上的天然药物，该幼虫各项营养成分较高，是一种很有开发价值的昆虫资源。     

从人性作秀到“存在意义的失落”——《儒林外史》中的匡超人形象分析

匡超人人物性格的形成及转变,一方面是受社会环境的影响,另一方面又有其自身的因素。对“功名富贵”的追求是匡超人转变的首要内因。当尽孝与科举功名道路发生冲突时,匡超人选择的是利己原则,这是理解匡超人这个人物变质的关键,也是这个典型人物的总特征。过人的精力、智力和外“乖”内“韧”的性格是匡超人变质的又一重要内因。未发迹的他已初露势利之心。匡超人自身的内因和外因交互作用,才形成匡超人这个典型人物,他的变质堕落不仅是他个人的悲剧,而且更具有社会性和时代性。     

The Shwachman-Bodian-Diamond syndrome protein mediates translational activation of ribosomes in yeast

The autosomal recessive disorder Shwachman-Diamond syndrome, characterized by bone marrow failure and leukemia predisposition, is caused by deficiency of the highly conserved Shwachman-Bodian-Diamond syndrome (SBDS) protein. Here, we identify the function of the yeast SBDS ortholog Sdo1, showing that it is critical for the release and recycling of the nucleolar shuttling factor Tif6 from pre-60S ribosomes, a key step in 60S maturation and translational activation of ribosomes. Using genome-wide synthetic genetic array mapping, we identified multiple TIF6 gain-of-function alleles that suppressed the pre-60S nuclear export defects and cytoplasmic mislocalization of Tif6 observed in sdo1Delta cells. Sdo1 appears to function within a pathway containing elongation factor-like 1, and together they control translational activation of ribosomes. Thus, our data link defective late 60S ribosomal subunit maturation to an inherited bone marrow failure syndrome associated with leukemia predisposition.     

A recurrent mutation in MED12 leading to R961W causes Opitz-Kaveggia syndrome

Opitz-Kaveggia syndrome (also known as FG syndrome) is an X-linked disorder characterized by mental retardation, relative macrocephaly, hypotonia and constipation. We report here that the original family for whom the condition is named and five other families have a recurrent mutation (2881C>T, leading to R961W) in MED12 (also called TRAP230 or HOPA), a gene located at Xq13 that functions as a thyroid receptor-associated protein in the Mediator complex.     

基于双目标规划和遗传算法的航线配船优化

为弥补目前航线配船问题研究存在的不足,以最大化船公司航线运营利润、最小化运力浪费为目标,建立双目标航线配船模型.同时为避免目前航线配船模型求解方式的繁琐,尝试将航线配船问题的可行解用染色体形式表示,通过遗传算法在解空间内的遍历和搜索,得到问题的满意解.实例分析证明了模型的可行性和算法的有效性.     

基于孤岛划分约束的有源配电网故障恢复策略

为提高供电恢复效果,更好地应对当前有源配电网信息-物理耦合程度不断加深的形势,提出了一种考虑信息流、能量流、业务流多流融合以及智能软开关(soft open point,SOP)作用的孤岛划分算法,基于该算法实现供电恢复策略。首先,为保证负荷的可靠恢复,该策略深入研究信息-物理耦合并建模,对节点信息重要度排序,讨论其对负荷恢复的影响;其次,构建了SOP的稳态模型,分析了SOP的工作原理及控制模式;接着,为了更大程度、更加灵活地恢复负荷,考虑SOP的作用,建立考虑光伏时变性及负荷运行特性的有源配电网孤岛划分模型;最后,算例仿真验证所提策略的有效性。     

松嫩平原参考作物蒸散量变化及其影响因素分析

利用松嫩平原19个站点的常规气象数据,采用FAO最新推荐的P—M公式计算了松嫩平原2000—2007年的参考作物日蒸散量、月蒸散量及年蒸散量,在此基础上分析了参考作物蒸散量的年际、年内时空变化特征,并探讨了参考作物蒸散量对主要影响因素的敏感性。结果表明：①松嫩平原的多年平均参考作物蒸散量从东北向西南逐渐增加,通榆、白城为全区的高蒸散中心,北安为低蒸散中心;②松嫩平原多年平均参考作物月蒸散量最高值出现在5月,而不是出现在气温最高的7月,最低气温出现在1月;③在参考作物蒸散量的诸多影响因素中,日最高气温、日平均相对湿度的影响最为明显,其次是日平均风速与日照时数,日最低气温与高程对参考作物蒸散量的影响很小,几乎可以忽略。图8,表2,参15。关键词：松嫩平原;参考作物蒸散;Penman—Monteith公式;敏感性分析     

Modeling for UAV resource scheduling under mission synchronization

Unmanned aerial vehicle (UAV) resource scheduling means to allocate and aggregate the available UAV resources depending on the mission requirements and the battlefield situation assessment. In previous studies, the models cannot reflect the mission synchronization; the targets are treated respectively,which results in the large scale of the problem and high computational complexity. To overcome these disadvantages, a model for UAV resource scheduling under mission synchronization is proposed, which is based on single-objective non-linear integer programming. And several cooperative teams are aggregated for the target clusters from the available resources. The evaluation indices of weapon allocation are referenced in establishing the objective function and the constraints for the issue. The scales of the target clusters are considered as the constraints for the scales of the cooperative teams to make them match in scale. The functions of the intersection between the "mission time-window" and the UAV "arrival time-window" are introduced into the objective function and the constraints in order to describe the mission synchronization effectively. The results demonstrate that the proposed expanded model can meet the requirement of mission synchronization, guide the aggregation of cooperative teams for the target clusters and control the scale of the problem effectively.