Energetic landscape of alpha-lytic protease optimizes longevity through kinetic stability.

During the evolution of proteins the pressure to optimize biological activity is moderated by a need for efficient folding. For most proteins, this is accomplished through spontaneous folding to a thermodynamically stable and active native state. However, in the extracellular bacterial alpha-lytic protease (alphaLP) these two processes have become decoupled. The native state of alphaLP is thermodynamically unstable, and when denatured, requires millennia (t1/2 approximately 1,800 years) to refold. Folding is made possible by an attached folding catalyst, the pro-region, which is degraded on completion of folding, leaving alphaLP trapped in its native state by a large kinetic unfolding barrier (t1/2 approximately 1.2 years). alphaLP faces two very different folding landscapes: one in the presence of the pro-region controlling folding, and one in its absence restricting unfolding. Here we demonstrate that this separation of folding and unfolding pathways has removed constraints placed on the folding of thermodynamically stable proteins, and allowed the evolution of a native state having markedly reduced dynamic fluctuations. This, in turn, has led to a significant extension of the functional lifetime of alphaLP by the optimal suppression of proteolytic sensitivity.     

基于Laguerre函数模型的多变量广义预测自适应控制

通过对Laguerre函数模型结构的分析 ,把多变量广义预测自适应控制方法应用于该模型中 ,利用Laguerre函数模型近似控制对象系统结构 ,将模型中间参量的辨识和模型的预测输出有效的统一了起来 ,克服了单纯基于参数化模型预测控制通常需要已知系统的时延和阶次的局限 ,为适合该类模型的工业对象应用提供一种有参考价值的控制方法。     

Comparative study of the karyotypes of two Egyptian species of bats,Taphozous perforatus andTaphozous nudiventris (Chiroptera: Mammalia)

A detailed karyotypic analysis of two Egyptian species of bats,Taphozous perforatus andTaphozous nudiventris, was made on the basis of conventional data and G-band patterns. No detectable karyotypic difference was found between the two species (2n=42, F.N. 64). By comparison of G-band patterns, some differences between the two species were seen in the corresponding autosomal pairs. These results are reported for the first time in Egypt.     

SIMULTANEOUS REACTION AND LIQUID-LIQUID EXTRACTION IN THE HYDROGEN PEROXIDE PRODUCTION

The gas-liquid-liquid reactive extraction system for preparing hydrogen peroxide via anthraquinone was investigated. The oxidation reaction of hydrogenated working solution was combined with the extraction of hydrogen peroxide from working solution in a sieve plate column. The reaction of 2-ethylanthrahydroquionone with oxygen and the liquid-liquid extraction of hydrogen peroxide take place simultaneously. The oxygen was introduced with hydrogenated working solution through a nozzle in the bottom of the column, which worked as agitated air as well as oxidation reagent. The results showed the oxidation and extraction do not hamper each other, on the contrary, the presence of oxidation gas in the column can promote the transfer of hydrogen peroxide from organic phase to aqueous phase, thus the reaction efficiency and extraction efficiency increased with increasing gas superficial velocity. Furthermore, the oxidation efficiency is almost 100% and the extraction efficiency is higher than 90% in this process.     

财务报表的时间性特征及其对财务分析的影响

财务报表中的各种指标按所反映的企业资金运动的时间状况，可分为反映企业资金运动在某一时刻状况的指标和反映企业资金运动在某一时期内发展变化结果的指标两大类：充分认识财务报表指标的时间性特征，有利于人们了解它对财务分析的影响。从而正确计算和运用某些财务分析指标。     

Web环境下的火工品感度虚拟仿真测试

应用WWW上的虚拟现实建模语言VRML，制作了可在Internet上应用Ⅲ和Netscape等普通浏览器进行交互操作的火工品感度虚拟仿真测试系统，对实现该测试系统的关键技术进行了论述。该虚拟仿真测试系统具有高度的真实效果，使操作人员如同在实地进行真正测试一样，是虚拟现实技术在万维网上的具体应用。     

反应条件及添加惰性物质对三聚甲醛合成反应的影响

研究了三聚甲醛合成过程进料浓度、催化剂用量等对副产物（特别是甲酸）生成行为的影响。结果表明，该体系副产物的生成强烈地依赖于反应时间和催化剂硫酸的用量，而与原料浓度的波动无关。在反应－精馏过程的反应器中添加惰性高沸有机物，可有效地缩短反应物的停留时间，提高三聚甲酸的选择性，大大降低快速反应－精馏过程对反应器的设计要求。     

基于框图建模的表现模型研究

讨论了表现模型的概念和构成，以及它与可视化模型和仿真模型的关系。在此基础上，以交战级仿真应用为背景，设计和实现了基于框图建模方法的表现模块库。用户可以根据需要，通过选取相应的功能模块，订购相应的仿真模型数据，建立表现模块之间的输入输出关系，和设置表现模块的功能参数来快速构建三维表现模型。该表现模型将仿真模型和仿真表现分离，在仿真演示上具有灵活、通用的特点。     

基于IP多播的机房信息管理系统的设计与实现

提出了一种基于IP多播技术的解决方案并加以实现,满足了对上机学生按系或班级分组进行管理与各类统计的需要,实现了传统C/S结构所能实现的全部功能,解决了传统机房信息管理系统使用带来的问题。