Roles of protein kinase C in oocyte meiotic maturation and fertilization

Protein kinase C (PKC) is a superfamily of Ser/Thr protein kinases that is distributed widely in eukaryotes. It plays key regulatory roles at multiple steps of oocyte meiotic maturation and fertilization. During the process of meiotic maturation, the activation of PKC in cumulus cells stimulates meiotic maturation, whereas the activation of PKC in oocytes results in the inhibition of germinal vesicle breakdown. PKC activity increases following the meiotic maturation, and decreases at the transition of metaphase/anaphase in meiosis I, so as to facilitate the release of the first polar body and the entry of meiosis II. In fertilization of mammalian oocytes, PKC may act as one of the downstream targets of Ca2+ to stimulate the cortical granule exocytosis, release the oocytes from MII arrest and to induce pronucleus formation. PKC is also involved in the regulation of maturation promoting factor (MPF) and mitogen-activated protein kinase (MAPK). Several PKC isoforms have been identified in mammalian oocytes, and there is evidence showing that classical PKCs may be the principal mediator of oocyte cortical reaction.     

大学预科化学课程教学探讨

本针对大学预科班学生的特点，从大学预科化学课程的基本目的和要求出发，讨论大学预科化学课程教学中应注意的问题．     

关于生物高分子元素活性中心分布规律的第四统计力学理论标度的研究(Ⅱ)——心血管中药的生命动力元素按原子序数分布的规律与群子参数间关系

首次采用第四统计力学群子理论对心血管中药中生命动力元素的分布规律进行了系统的研究 ,结果表明心血管中药的生命动力元素按原子序数分布呈现出如下四种分布规律，即不同中药有轻度元素分布、较轻度元素分布、较重度元素分布和重度元素分布 ,并且每一种分布根据R₂ /R₁的值又可分为两个分支。本文还首次阐述了群子统计参数R₁、R₂ 、R₂ /R₁及R₁·R₂ 在中药生命动力元素分布中的物理内涵。这些研究为进一步定量地研究中药的性味和药效之间的关系提供了必要的依据。     

Land vehicle positioning using GPS and dead reckoning

To ensure reliable land vehicle positioning, the Global Positioning System (GPS) is one of the best techniques commonly used in present-day positioning systems. However, GPS signals are not available if line of sight with the satellites is lost. In this respect, the addition of the Dead Reckoning (DR) method to complement the GPS unit would enhance the reliability of land vehicle positioning system. For implementing the DR method, the magnetic sensor and accelerometer are used for obtaining heading and velocity or distance information. Calibration of two sensors' dynamic model and DR algorithm are also introduced in this paper. The test result utilizing the GPS and DR methods is analyzed in this paper. It utilize spositioning information from GPS receiver when GPSsignal is available, otherwise DR is started to compensate GPS outage with the GPS output as the original point. The results showed that the error in east and north produced by the DR algorithm for a short time interval can be limitedwithin an acceptable range.     

In-vehicle GPS/DR navigation system development and test results in Singapore

This paper introduces the in-car navigation system prototype development and test results under the context of Singapore. In the system, integrated GPS/DR is used for continuous vehicle positioning. A digital road network map database is built for the whole Singapore. The database is designed to support map matching, route determination, and route guidance functions. The prototype system demonstrates GPS positioning of the vehicle in real-time, tracking the vehicle onto a digital map with fix updates every one or two seconds.With the map matched vehicle location on the map, voice and/or text guidance is provide to the driver. The vehicle position can also be transferred to control centre through communication data link for the purpose of fleet management.     

A carbon- and oxygen-isotope record of recent environ- mental change from Qinghai Lake, NE Tibetan Plateau

An understanding of natural climatic variability is essential for evaluating anthropogenic impacts on recent and future climate[1—3]. Due to the lack of lengthy instrumental records, such an understanding must be gained from natural archives of climate change. Palaeolimnological indicators of past lake levels may provide a sensitive record of changes in effective precipitation in closed basins. This approach is particularly relevant on the Tibetan Plateau, where instrumental records are very…     

数控机床的电器故障诊断及维修

与传统机床维修方式相比，数控机床在维修理论、技术和手段上有了巨大的变化。维修前要做好技术、工具与备件的准备。进行故障现场调查与检查，归纳可能造成故障的所有原因，确定故障产生原因。     

湿地生态安全评价刍议

由于缺乏必要的科学信息，我们仍然无法知晓人类活动对湿地生态系统的影响以及温地生态系统安全状况的变化对人类自身生存发展带来的影响，所以，建立湿地生态安全评价体系，提供湿地生态安全信息，是进行温地生态安全管理、保证温地资源可持续利用不可或缺的基础。     

三相串联电能质量控制器及其补偿电压算法

为了抑制系统电压的跌落和消除电压谐波,提出了一种新型的三相串联电压质量控制器。利用向量图和几何方法对串联控制器的补偿极限进行了分析,提出了向三相三线制系统中注入零序电压以提高串联单元补偿极限的方法。新型的补偿电压控制算法可以快速得到三相交流补偿电压。利用对补偿极限的研究结果和补偿电压的控制算法,串联装置可以对稳态电压跌落和电压谐波进行治理,并且极大地提高了补偿极限。运用电力系统仿真软件PSCAD/EMTDC对该方法进行仿真,结果证明了理论分析和设计的有效性。     

泥石流危险性动量分区方法与应用

运用泥石流运动数值模拟和GIS相结合的方法模拟泥石流出山口后的运动全过程, 求得泥石流流速和流深分布, 确定泥石流过程中泛滥范围内任一点的最大动量, 建立了泥石流危险性动量分区模型Z = Khv. 根据考察和实验资料对委内瑞拉首都加拉加斯的Chacaito沟百年一遇泥石流运动过程进行了模拟, 利用动量分区方法划分出泥石流危险区.