Biomimetic fluorapatite films for conservation of historic calcareous stones

Fluorapatite protective films were prepared on marble substrates using a biomimetic method. By mimicking the mineralization mechanism of enamel, phosphorus and fluorine were introduced on the surface of the marble substrate. In the presence of a biological template, namely collagen, an integrated fluorapatite film was produced and the marble substrate was entirely covered. The prepared fluorapatite films were characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), and energy dispersive X-ray (EDX) spectroscopy. The performances of the fluorapatite films were evaluated by color changes, capillary water absorption, and acid resistance tests. The results revealed that the fluorapatite films had good compatibility with the marble substrate; the physical properties such as color and capillary water adsorption of the marble substrates were unchanged. The fluorapatite films also had good acid resistance and were stable even in heavy acid rain.     

A numerical method to simulate the coupled oscillations of flexible structures in flowing fluids

A numerical method is developed to simulate the coupled phenomena in a fluid-flexible-structure system. Specifically, a two-dimensional panel method is used to calculate the hydrodynamic forces and a modal superposition method is adopted to solve the governing equation of an Eulerian beam. The stability boundary of a single flexible beam in a uniform flow is calculated and compared with previous results to verify the validity of the code. The flow-induced flapping of a single and two flexible bodies for S=1.0, U*=7.0 are investigated. For the flow-induced vibration of a single beam, the oscillation frequency is close to the secondary natural frequency of a cantilever. For two parallel flexible beams, they oscillate in phase when the non-dimensional separating distance H<0.25. When H>0.25, the out-of-phase mode occurs with a jump in frequency. When H>1, the interaction between the two beams decouples and the frequency and forces of each beam revert to behavior associated with a single beam in the same flow. Simulations of coupled-flapping of two tandem flexible structures proved that the drag acting on the upstream body is reduced while for that downstream drag is obviously increased when the structures are closely arranged. The numerical results obtained in the present work are qualitatively consistent with early experimental results.     

Radioprotectors from pyrodextrins

Cornstarch heated in the range of 230–280°C depolymerized into pyrodextrins characterized by two-component EPR signals of relatively stable free radicals. These thermally generated radicals could serve as efficient scavengers for free radicals generated from pyrodextrins with the 200 Gy dose of γ-radiation. The most efficient traps/scavengers were produced from cornstarch at 250–280°C. IR data indicated incorporation of the OH groups to the pyrodextrins. These groups most probably originated from the OH· radicals formed by the radiolysis of water. EPR spectra provided evidence for trapping free radicals generated by γ-irradiation and for their subsequent annihilation on contact with pyrodextrins. Water affected radical processes occurring in pyrodextrins caused by γ-irradiation.     

二次型在超曲面上条件极值的矩阵解法

利用矩阵理论得到了二次型在一般的二次超曲面上取得条件极值的充分条件，并结合实例用Matlab编程实现了求解过程．     

Automatic identification of use cases from codes: A user’s goal driven approach

Based on the different roles played by base flow and alternative flow in the process to achieve user’s goals, we have found that loop structure is frequently used to implement alternative flow and/or to connect different use cases. This paper presents an approach to identify base flows and alternative flows of different use cases by traversing control flow graph in which back edges are eliminated. The effectiveness of the approach is verified by identification of the use case structure of an ATM system. The workload of human intervention of the approach is relatively slight, and the manner of human intervention closely follows the usual process of software comprehension.     

Identification of a bacterial inhibitor against g-type lysozyme

Lysozymes are antibacterial effectors of the innate immune system in animals that hydrolyze peptidoglycan. Bacteria have evolved protective mechanisms that contribute to lysozyme tolerance such as the production of lysozyme inhibitors, but only inhibitors of chicken (c-) and invertebrate (i-) type lysozyme have been identified. We here report the discovery of a novel Escherichia coli inhibitor specific for goose (g-) type lysozymes, which we designate PliG (periplasmic lysozyme inhibitor of g-type lysozyme). Although it does not inhibit c- or i-type lysozymes, PliG shares a structural sequence motif with the previously described PliI and MliC/PliC lysozyme inhibitor families, suggesting a common ancestry and mode of action. Deletion of pliG increased the sensitivity of E. coli to g-type lysozyme. The existence of inhibitors against all major types of animal lysozyme and their contribution to lysozyme tolerance suggest that lysozyme inhibitors may play a role in bacterial interactions with animal hosts.     

Molecular basis of parathyroid hormone receptor signaling and trafficking: a family B GPCR paradigm

The parathyroid hormone (PTH) receptor type 1 (PTHR), a G protein-coupled receptor (GPCR), transmits signals to two hormone systems—PTH, endocrine and homeostatic, and PTH-related peptide (PTHrP), paracrine—to regulate different biological processes. PTHR responds to these hormonal stimuli by activating heterotrimeric G proteins, such as G_S that stimulates cAMP production. It was thought that the PTHR, as for all other GPCRs, is only active and signals through G proteins on the cell membrane, and internalizes into a cell to be desensitized and eventually degraded or recycled. Recent studies with cultured cell and animal models reveal a new pathway that involves sustained cAMP signaling from intracellular domains. Not only do these studies challenge the paradigm that cAMP production triggered by activated GPCRs originates exclusively at the cell membrane but they also advance a comprehensive model to account for the functional differences between PTH and PTHrP acting through the same receptor.     

某轿车的铰接点——A点优化设计

对某轿车的铰接点(A点)进行了刚度及其灵敏度分析,并在此基础上对A点进行了优化,对比分析优化后的A点发现,重量减轻了,刚度并没有减弱.说明这种以减重为目标的优化分析方法是有效可行的.     

An improved 3-D ray tracing method using linear traveltime interpolation

An approach of three-dimensional seismic ray tracing is presented, which is derived from adopting two-dimensional linear traveltime interpolation (LTI). By adjusting the forward process using the partition of grid interface, and backward step by considering more directions, the new approach is suitable for the application of three-dimensional models. The calculation results show that, with the same accuracy, the improved 3-D method is much faster than the method of traditional LTI directly applied in the three-dimensional case.     

Language clusters based on linguistic complex networks

To investigate the feasibility of using complex networks in the study of linguistic typology, this paper builds and explores 15 lin-guistic complex networks based on the dependency syntactic treebanks of 15 languages. The results show that it is possible to classify human languages by means of the following main parameters of complex networks: (a) average degree of the node, (b) cluster coefficients, (c) average path length, (d) network centralization, (e) diameter, (f) power exponent of degree distribution, and (g) the determination coefficient of power law distributions. The precision of this method is similar to the results achieved by means of modern word order typology. This paper tries to solve two problems of current linguistic typology. First, the language sample of a typological study is not real text; second, typological studies pay too much attention to local language structures in the course of choosing typological parameters. This study performs better in global typological features of language and not only enhances typological methods, but it is also valuable for developing the applications of complex networks in the humanities, social, and life sciences.