兴义坡岗自然保护区陆生贝类资源调查及区系分析(腹足纲:前鳃亚纲;肺螺亚纲)

对贵州省兴义市坡岗自然保护区进行陆生贝类资源调查,共获得标本2 954号,经鉴定得66种(8个未定种),分隶于12科32属。区系分析表明:保护区内陆生贝类以东洋界种类为主,占种类总数的89%。东洋界西南区种类,占种类总数的33%;同时也有少数古北界的种类渗透,占种类总数的7%;广分布种类较少,仅占种类总数的4%。     

渡槽整体结构环境激励模态试验

为获得渡槽整体结构动力特性,开展单向SIMO法、双向MIMO法环境激励模态试验,选用增强频域分解法识别纵向、横向、竖向、横竖双向模态参数.结果表明:2种方法识别出的模态大多数谱峰明显、识别效果较好;纵向模态以排架结构振动为主,槽身整体平动或转动或不动;前4阶横向模态以排架结构振动为主,槽身整体平动或转动或横摇,第5阶模...     

对现代园林植物景观设计的理性思考

植物景观设计是现代园林景观设计的重要内容．针对现代园林植物景观设计中出现的问题和误区,提出了现代园林植物景观设计应遵循自然为先的原则．     

视频点播系统交互式功能的设计与实现

针对视频点播系统的交互特性,在使用MPEG标准的基础上,利用空间换效率的思想,建立Ⅰ帧文件及其索引,进而提出了单道交互式功能的调度模型,实现了类视频录像系统的交互式功能,如快进、快退、暂停、随机读取和恢复播放等．根据IP组播技术的特点,为用户建立专用的类视频录像操作的数据通道提供非单道模式下的数据传输,并利用流的分离与合并技术,给出了流共享机制下实现交互式功能的解决方案．单道交互式功能的测试显示出播放、快进和快退等状态能够进行平滑切换,达到录像机相应操作状态的效果．     

二母散对博来霉素诱导大鼠肺纤维化模型FGF、CTGF和CollagenⅠ表达的影响

目的 研究二母散对大鼠肺纤维化模型的作用及其作用机制.方法 50只SPF级SD大鼠按体质量随机分为假手术组(SC组)、模型对照组(M组)、二母散低剂量组(1.08 g生药/kg,EL组)、二母散高剂量组(2.16 g生药/kg,EH组)、泼尼松对照组(5.4 mg/kg,PR组).大鼠经乙醚麻醉后切开颈部皮肤,暴露气管...     

地应力测量非弹性应变恢复法在某金属矿的应用

为获得某金属矿深部岩体地应力分布特征,采用非弹性应变恢复法,选取该矿同一勘探线附近距地表埋深615 m、665 m、715 m三个水平进行现场地应力测量。通过分析3个水平各测点地应力测量结果,得到该矿区地应力分布规律。该矿区最大主应力和最小主应力均为近水平主应力,中间主应力为近垂向的应力;3个水平的最大水平主应力方向基本一致,方位角为101°～130°。主应力的大小随深度呈线性增长。近水平应力大于近垂向应力,表明该矿浅部地壳应力占主导地位的是水平构造应力。两个相邻样品的非弹性应变恢复法地应力测量值平均差系数最大为8.33%,表明其结果具有较好的一致性,验证了非弹性应变恢复法的可靠性。     

基于类别不平衡的企业信用风险违约测度探索 ——以制造业上市公司为例

针对所获取的类别不平衡的深沪A股制造业上市公司财务数据,为了预测制造业上市公司信用违约情况,提出基于欠采样改进的Lasso-Logistic模型;首先通过计算WOE和IV值,剔除风险识别能力和稳定性较差的变量,接着从"数据"层面对现有的Lasso-Logistic模型进行批量欠采样处理,最后结合"算法"层面对Lasso...     

Cystic fibrosis transmembrane conductance regulator—emerging regulator of cancer

Mutations of cystic fibrosis transmembrane conductance regulator (CFTR) cause cystic fibrosis, the most common life-limiting recessive genetic disease among Caucasians. CFTR mutations have also been linked to increased risk of various cancers but remained controversial for a long time. Recent studies have begun to reveal that CFTR is not merely an ion channel but also an important regulator of cancer development and progression with multiple signaling pathways identified. In this review, we will first present clinical findings showing the correlation of genetic mutations or aberrant expression of CFTR with cancer incidence in multiple cancers. We will then focus on the roles of CFTR in fundamental cellular processes including transformation, survival, proliferation, migration, invasion and epithelial–mesenchymal transition in cancer cells, highlighting the signaling pathways involved. Finally, the association of CFTR expression levels with patient prognosis, and the potential of CFTR as a cancer prognosis indicator in human malignancies will be discussed.     

Interleukin-33 stimulates formation of functional osteoclasts from human CD14+ monocytes

Interleukin (IL)-33 is a recently described pro-inflammatory cytokine. Here we demonstrate IL-33 as a regulator of functional osteoclasts (OCs) from human CD14⁺ monocytes. IL-33 stimulates formation of tartrate-resistant acid phosphatase (TRAP)⁺ multinuclear OCs from monocytes. This action was suppressed by anti-ST2 antibody, suggesting that IL-33 acts through its receptor ST2, but not by the receptor activator of NF-κB ligand (RANKL) decoy, osteoprotegerin, or anti-RANKL antibody. IL-33 stimulated activating phosphorylations of signaling molecules in monocytes that are critical for OC development. These included Syk, phospholipase Cγ2, Gab2, MAP kinases, TAK-1, and NF-κB. IL-33 also enhanced expression of OC differentiation factors including TNF-α receptor-associated factor 6 (TRAF6), nuclear factor of activated T cells cytoplasmic 1, c-Fos, c-Src, cathepsin K, and calcitonin receptor. IL-33 eventually induced bone resorption. This study suggests that the osteoclastogenic property of IL-33 is mediated through TRAF6 as well as the immunoreceptor tyrosine-based activation motif-dependent Syk/PLCγ pathway in human CD14⁺ monocytes.