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991.
本文提出了测量Ng10二通插装阀静,动态性能的试验方法,测试了阀套开口形状、各种尾部结构的阀芯、阀芯行程、阀芯锥度、控制盖板阻尼孔尺寸等结构形状参数对插装阀静、动态性能的影响,并对试验结果进行了对比分析.在此基础上.确定了本文述及条件下的最佳结构形状和参数. 相似文献
992.
从压力角表达式出发,提出了构造凸轮机构类速度图的一种有效方法。它对于平面与空间凸轮机构同样适用。 相似文献
993.
通信装备备件保障系统的复杂性决定了运用建模仿真技术对其性能研究的适用性及有效性。针对两级备件保障体制下备件配置问题,在分析通信装备备件保障流程的基础上,以备件利用率及故障装备修复率为输出指标,利用Arena仿真软件建立了基于流程的通信装备备件保障系统仿真模型。通过仿真实例,分析了不同备件配置策略对备件利用率及故障装备修复率的影响规律,仿真结果验证了模型的有效性,同时也表明:相比传统建模方法,在描述备件保障过程中变量的随机特性及系统的动态行为方面,Arena软件有显著的有效性和优越性。 相似文献
994.
Liu G Parant JM Lang G Chau P Chavez-Reyes A El-Naggar AK Multani A Chang S Lozano G 《Nature genetics》2004,36(1):63-68
The p53 protein integrates multiple upstream signals and functions as a tumor suppressor by activating distinct downstream genes. At the cellular level, p53 induces apoptosis, cell cycle arrest and senescence. A rare mutant form of p53 with the amino acid substitution R175P, found in human tumors, is completely defective in initiating apoptosis but still induces cell cycle arrest. To decipher the functional importance of these pathways in spontaneous tumorigenesis, we used homologous recombination to generate mice with mutant p53-R172P (the mouse equivalent of R175P in humans). Mice inheriting two copies of this mutation (Trp53(515C/515C)) escape the early onset of thymic lymphomas that characterize Trp53-null mice. At 7 months of age, 90% of Trp53-null mice had died, but 85% of Trp53(515C/515C) mice were alive and tumor-free, indicating that p53-dependent apoptosis was not required for suppression of early onset of spontaneous tumors. The lymphomas and sarcomas that eventually developed in Trp53(515C/515C) mice retained a diploid chromosome number, in sharp contrast to aneuploidy observed in tumors and cells from Trp53-null mice. The ability of mutant p53-R172P to induce a partial cell cycle arrest and retain chromosome stability are crucial for suppression of early onset tumorigenesis. 相似文献
995.
Comparative studies on phenotypic plasticity of two herbs, Changium smyrnioides and Anthriscus sylvestris 总被引:1,自引:0,他引:1
The endangered medicinal herb, Changium smyrnioides can only be found in deciduous forest gaps within the middle to northern subtropical broad-leaved evergreen forest zone of China. The considerable plasticity of its shoot and root structure helps it to capture light more effectively in winter and early spring, and to adapt to the soil moisture conditions in its narrow habitat. Another medicinal plant, Anthriscus sylvestris, is of similar economic importance but commonly distributed widely. In contrast to C. smyrnioides, it has low structural plasticity. It is also specialized to adapt to the moist and sunny environment, where habitat, such as the banks of creeks and rivers, is abundant. 相似文献
996.
Chang S Multani AS Cabrera NG Naylor ML Laud P Lombard D Pathak S Guarente L DePinho RA 《Nature genetics》2004,36(8):877-882
Mutational inactivation of the gene WRN causes Werner syndrome, an autosomal recessive disease characterized by premature aging, elevated genomic instability and increased cancer incidence. The capacity of enforced telomerase expression to rescue premature senescence of cultured cells from individuals with Werner syndrome and the lack of a disease phenotype in Wrn-deficient mice with long telomeres implicate telomere attrition in the pathogenesis of Werner syndrome. Here, we show that the varied and complex cellular phenotypes of Werner syndrome are precipitated by exhaustion of telomere reserves in mice. In late-generation mice null with respect to both Wrn and Terc (encoding the telomerase RNA component), telomere dysfunction elicits a classical Werner-like premature aging syndrome typified by premature death, hair graying, alopecia, osteoporosis, type II diabetes and cataracts. This mouse model also showed accelerated replicative senescence and accumulation of DNA-damage foci in cultured cells, as well as increased chromosomal instability and cancer, particularly nonepithelial malignancies typical of Werner syndrome. These genetic data indicate that the delayed manifestation of the complex pleiotropic of Wrn deficiency relates to telomere shortening. 相似文献
997.
Room-temperature ferroelectricity in strained SrTiO3 总被引:1,自引:0,他引:1
Haeni JH Irvin P Chang W Uecker R Reiche P Li YL Choudhury S Tian W Hawley ME Craigo B Tagantsev AK Pan XQ Streiffer SK Chen LQ Kirchoefer SW Levy J Schlom DG 《Nature》2004,430(7001):758-761
Systems with a ferroelectric to paraelectric transition in the vicinity of room temperature are useful for devices. Adjusting the ferroelectric transition temperature (T(c)) is traditionally accomplished by chemical substitution-as in Ba(x)Sr(1-x)TiO(3), the material widely investigated for microwave devices in which the dielectric constant (epsilon(r)) at GHz frequencies is tuned by applying a quasi-static electric field. Heterogeneity associated with chemical substitution in such films, however, can broaden this phase transition by hundreds of degrees, which is detrimental to tunability and microwave device performance. An alternative way to adjust T(c) in ferroelectric films is strain. Here we show that epitaxial strain from a newly developed substrate can be harnessed to increase T(c) by hundreds of degrees and produce room-temperature ferroelectricity in strontium titanate, a material that is not normally ferroelectric at any temperature. This strain-induced enhancement in T(c) is the largest ever reported. Spatially resolved images of the local polarization state reveal a uniformity that far exceeds films tailored by chemical substitution. The high epsilon(r) at room temperature in these films (nearly 7,000 at 10 GHz) and its sharp dependence on electric field are promising for device applications. 相似文献
998.
LIYang WANGLiduo CHANGChun DUANLian QIUYong 《科学通报(英文版)》2004,49(13):1328-1331
The transparent ITO/Ag/ITO multi-layers are developed as anodes on flexible PET (poly(ethylene terephthalate)) substrates. The influence of these anodes on FOLED (Flexible Organic Light-emitting Diodes) is investigated. From the results of research, it can be seen that the multi-layer anode has optimum characteristics, whose sheetresistance is 11 Ω and optical transmittance is about 80%,when the thickness of Ag sandwiched by two ITO layers is in the range of 14--18 nm. It is demonstrated that the OLED devices with multi-layer anodes give better luminescence and higher efficiency compared with those with single ITO anodes. 相似文献
999.
Gray JM Karow DS Lu H Chang AJ Chang JS Ellis RE Marletta MA Bargmann CI 《Nature》2004,430(6997):317-322
Specialized oxygen-sensing cells in the nervous system generate rapid behavioural responses to oxygen. We show here that the nematode Caenorhabditis elegans exhibits a strong behavioural preference for 5-12% oxygen, avoiding higher and lower oxygen levels. 3',5'-cyclic guanosine monophosphate (cGMP) is a common second messenger in sensory transduction and is implicated in oxygen sensation. Avoidance of high oxygen levels by C. elegans requires the sensory cGMP-gated channel tax-2/tax-4 and a specific soluble guanylate cyclase homologue, gcy-35. The GCY-35 haem domain binds molecular oxygen, unlike the haem domains of classical nitric-oxide-regulated guanylate cyclases. GCY-35 and TAX-4 mediate oxygen sensation in four sensory neurons that control a naturally polymorphic social feeding behaviour in C. elegans. Social feeding and related behaviours occur only when oxygen exceeds C. elegans' preferred level, and require gcy-35 activity. Our results suggest that GCY-35 is regulated by molecular oxygen, and that social feeding can be a behavioural strategy for responding to hyperoxic environments. 相似文献
1000.
We continue our discussion of the competing arguments in favour of the unified theory and the pluralistic theory of radiation advanced by three nineteenth-century pioneers: Herschel, Melloni, and Draper. Our narrative is structured by a consideration of the epistemic criteria relevant to theory-choice; the epistemic focus highlights many little-known aspects of this relatively well-known episode. We argue that the acceptance of light-heat unity (and of the unified theory of radiation more generally) in this period cannot be credibly justified on the basis of common evaluative criteria such as simplicity and standard notions of explanatory power. Whether the consensus was justified by some other criteria remains an open question. 相似文献