On robust estimation of threshold autoregressions

We investigate the effects of additive outliers on the least squares (LS) estimation of threshold autoregressive models. The class of generalized-M (GM) estimates for linear time series is modified and applied to non-linear threshold processes. A Monte Carlo experiment is carried out to study the robust properties of these estimates. Their relative forecasting performances are also examined. The results indicate that the GM method is preferable to the LS estimation when the observations are contaminated by additive outliers. A real example is also given to illustrate the proposed method.     

AN FTIR SPECTROSCOPIC STUDY OF LOW TEMPERATURE PLASMA TREATED WOOL FABRIC

FTIR-ATR technique with second-order derivative measurement was used for assessing the amount of oxidation products of cystine present on the plasma-treated wool fabric surface. In this paper, three non-polymerising gases namely oxygen, nitrogen and 25% hydrogen/75% nitrogen gas mixture were used for the plasma treatment of wool fabric. The oxidation products of cystine studied included S-sulphonate, cysteic acid, cystine monoxide and cystine dioxide. The variations of the amount of these products as a function of treatment time were studied. Experimental results showed that the oxygen plasma could produce a large amount of oxidation products of cystine on the wool fabric surface followed by nitrogen plasma and gas mixture plasma.     

初等几何题的高等几何解法

本文论述采用高等几何的多种方法，解椭圆有关问题和线段长度有关问题的解法．     

Cyclic CMP (cytidine 3',5'-monophosphate) suppresses changes in human sperm amplitude of lateral head displacement and hyperactivation

The dibutyryl analog of cCMP suppressed sperm amplitude of lateral head displacement and hyperactivation. Sperm motility was inhibited by dibutyryl cCMP with a shift toward less linear trajectory sperm movements. The results suggest a role of cCMP as an inhibitory signal on sperm motility patterns related to sperm capacitation.     

面向产品工艺信息共享CAPP系统的开发研究

介绍了一种基于C/S模式的面向产品工艺信息共享CAPP系统 ,阐述了系统的主要功能、系统结构及软件组织和特点。并讨论了系统设计中的关键技术。     

Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma

Follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL) are the two most common non-Hodgkin lymphomas (NHLs). Here we sequenced tumour and matched normal DNA from 13 DLBCL cases and one FL case to identify genes with mutations in B-cell NHL. We analysed RNA-seq data from these and another 113 NHLs to identify genes with candidate mutations, and then re-sequenced tumour and matched normal DNA from these cases to confirm 109 genes with multiple somatic mutations. Genes with roles in histone modification were frequent targets of somatic mutation. For example, 32% of DLBCL and 89% of FL cases had somatic mutations in MLL2, which encodes a histone methyltransferase, and 11.4% and 13.4% of DLBCL and FL cases, respectively, had mutations in MEF2B, a calcium-regulated gene that cooperates with CREBBP and EP300 in acetylating histones. Our analysis suggests a previously unappreciated disruption of chromatin biology in lymphomagenesis.     

Consortium for the Human Information and Neurocognitive Endophenotype （CHINE） in mainland China： An example from neurological soft signs for neuropsychiatric disorders

Increasing efforts to identify alternate expressions of neuropsychiatric disorders that are broader than the DSM or ICD diagnostic criteria needed to diagnose them reflects a growing consensus that multidimensional expressions of neuropsychiatric disorders may advance the search for underlying etiological or modulatory factors. Endophenotypic research can be considered to be one of the most promising strategies to bridge the gap between genomic complexity and the phenotypic heterogeneity observed in neuropsychiatric disorders. However, the majority of endophenotype studies were limited to our western counterparts, very little has been done and initiated by scholars in mainland China. In this paper, we urge the need to establish a potential central consortium for endophenotypes to study neuropsychiatric disorders in mainland China. In particular, we illustrate a potential example of neurological soft signs in following the steps for building the consortium.     

精氨酸等物质对紫色红曲菌产Monacolin K及红曲色素的影响

基于前期的非靶向代谢组学研究结果,在红曲菌发酵液原有营养成分的基础上添加精氨酸、L-苹果酸、D-葡萄糖、烟酰胺、α-酮戊二酸、苯丙氨酸、赖氨酸、焦磷酸硫胺素、黄素单核苷酸、L-乳酸等差异代谢物,对发酵第8天和第15天的红曲色素以及Monacolin K的产量进行了分析。结果表明:精氨酸、苯丙氨酸、赖氨酸以及黄素单核苷酸的添加对Monacolin K产量的提高效果较好,推测氨基酸类物质的添加对Monacolin K产量有促进效果;其中精氨酸添加后效果最为显著,Monacolin K产量约为对照组的2.2～3.7倍。不同含量的烟酰胺对Monacolin K有不同的影响,低含量具有促进作用;而高含量则表现为抑制作用。赖氨酸、苯丙氨酸以及黄素单核苷酸对红曲色素提升效果较好,其中黄素单核苷酸可使红曲色素产量约提高至对照组的1.5～3.0倍。