全文获取类型
收费全文 | 194篇 |
免费 | 0篇 |
国内免费 | 1篇 |
专业分类
系统科学 | 1篇 |
理论与方法论 | 2篇 |
现状及发展 | 52篇 |
研究方法 | 23篇 |
综合类 | 101篇 |
自然研究 | 16篇 |
出版年
2021年 | 1篇 |
2018年 | 1篇 |
2017年 | 3篇 |
2016年 | 2篇 |
2015年 | 1篇 |
2013年 | 4篇 |
2012年 | 9篇 |
2011年 | 32篇 |
2010年 | 1篇 |
2008年 | 13篇 |
2007年 | 8篇 |
2006年 | 11篇 |
2005年 | 13篇 |
2004年 | 8篇 |
2003年 | 9篇 |
2002年 | 11篇 |
1997年 | 1篇 |
1996年 | 3篇 |
1994年 | 2篇 |
1991年 | 1篇 |
1989年 | 1篇 |
1985年 | 2篇 |
1984年 | 2篇 |
1981年 | 1篇 |
1980年 | 2篇 |
1979年 | 4篇 |
1978年 | 3篇 |
1977年 | 3篇 |
1976年 | 2篇 |
1975年 | 1篇 |
1974年 | 2篇 |
1973年 | 3篇 |
1972年 | 2篇 |
1971年 | 1篇 |
1970年 | 3篇 |
1969年 | 3篇 |
1968年 | 4篇 |
1967年 | 7篇 |
1966年 | 3篇 |
1965年 | 6篇 |
1964年 | 2篇 |
1958年 | 1篇 |
1957年 | 1篇 |
1954年 | 1篇 |
1947年 | 1篇 |
排序方式: 共有195条查询结果,搜索用时 492 毫秒
171.
172.
173.
174.
Genome-wide association study and mouse model identify interaction between RET and EDNRB pathways in Hirschsprung disease 总被引:13,自引:0,他引:13
Carrasquillo MM McCallion AS Puffenberger EG Kashuk CS Nouri N Chakravarti A 《Nature genetics》2002,32(2):237-244
Genetic studies of Hirschsprung disease, a common congenital malformation, have identified eight genes with mutations that can be associated with this condition. Mutations at individual loci are, however, neither necessary nor sufficient to cause clinical disease. We conducted a genome-wide association study in 43 Mennonite family trios using 2,083 microsatellites and single-nucleotide polymorphisms and a new multipoint linkage disequilibrium method that searches for association arising from common ancestry. We identified susceptibility loci at 10q11, 13q22 and 16q23; the gene at 13q22 is EDNRB, encoding a G protein-coupled receptor (GPCR) and the gene at 10q11 is RET, encoding a receptor tyrosine kinase (RTK). Statistically significant joint transmission of RET and EDNRB alleles in affected individuals and non-complementation of aganglionosis in mouse intercrosses between Ret null and the Ednrb hypomorphic piebald allele are suggestive of epistasis between EDNRB and RET. Thus, genetic interaction between mutations in RET and EDNRB is an underlying mechanism for this complex disorder. 相似文献
175.
Quantum encounters of the cold kind 总被引:2,自引:0,他引:2
Since the introduction of laser-cooling techniques for neutral atoms in the early 1980s, the study of collisional interactions between atoms and molecules has been extended to the regime of ultracold temperatures. With nanokelvin temperatures now attainable, our ability to probe the interactions, both experimentally and theoretically, has also progressed. Understanding of the subtle and often highly quantum-mechanical effects that are manifest at such low energies has advanced to the point where new precision measurements are matched by highly accurate theoretical calculations. Low-energy phenomena such as Bose-Einstein condensation and the photoassociation of atoms into bound molecules are now accurately described with no free parameters. 相似文献
176.
P A Parsons 《Experientia》1964,20(10):569-570
177.
Distribution of ribosomal RNA in fusing myoblasts 总被引:1,自引:0,他引:1
K F Ross D E Jans P F Larson F L Mastaglia R Parsons J J Fulthrope M Jenkinson J N Walton 《Nature》1970,226(5245):545-547
178.
Parsons DW Wang TL Samuels Y Bardelli A Cummins JM DeLong L Silliman N Ptak J Szabo S Willson JK Markowitz S Kinzler KW Vogelstein B Lengauer C Velculescu VE 《Nature》2005,436(7052):792
Protein kinases are enzymes that are important for controlling cellular growth and invasion, and their malfunction is implicated in the development of some tumours. We analysed human colorectal cancers for genetic mutations in 340 serine/threonine kinases and found mutations in eight genes, including in three members of the phosphatidylinositol-3-OH kinase (PI(3)K) pathway. The discovery of this mutational activation of a key cell-signalling pathway may provide new targets for therapeutic intervention. 相似文献
179.
180.