We report the first identified mutation in the gene encoding human cytochrome c (CYCS). Glycine 41, invariant throughout eukaryotes, is substituted by serine in a family with autosomal dominant thrombocytopenia caused by dysregulated platelet formation. The mutation yields a cytochrome c variant with enhanced apoptotic activity in vitro. Notably, the family has no other phenotypic indication of abnormal apoptosis, implying that cytochrome c activity is not a critical regulator of most physiological apoptosis. 相似文献
The objective of this study was to conduct Action Research (AR) to create and implement a WEEE management program that was in line with the BNPSW regulations. The city chosen for this study was São João del Rei (SJDR) located in the state of Minas Gerais, Brazil. Using AR it was possible to structure a WEEE management program that involved stakeholders from the city administration, the Federal University of São João del Rei, and representatives from the private sector. The program ultimately collected 1710 kg of WEEE that received an environmentally appropriate destination. Although no major difficulties were observed with respect to the AR process itself, some challenges were encountered. Lack of infrastructure and hesitance on behalf of the public with respect to implementing WEEE Reverse Logistics were complicating factors. The action research as methodology proved to be highly efficient in dealing with e-waste reverse logistics. It resulted in faster decision making, in turn generating better results. Good decisions were repeated and errors were corrected. The Action Research project highlighted the need for raising public awareness about WEEE disposal. It also showed that the public was ultimately interested in participating and contributing to the proposed WEEE management program. The awareness of the population has led to a significant increase in the amount of collected waste. The model resulting from this research serve as a reference for decision makers in implementing similar programs around the world and to contribute to the existing body of knowledge on the subject.