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141.
A. Gomes da Costa 《Cellular and molecular life sciences : CMLS》1978,34(1):82-83
Summary Filamentous bodies have been identified in the glomerular cells of human kidney biopsies. These structures have a close morphological resemblance to ciliary rootlets, although the cells of the glomerular tuft only occasionally bear cilia. Their significance could be, as for cilia, of a cellular disdifferentiation of a pathological cellular proliferation. 相似文献
142.
The fixative action of uranyl acetate in electron microscopy 总被引:3,自引:0,他引:3
M. T. Silva F. Carvalho Guerra M. M. Magalhães 《Cellular and molecular life sciences : CMLS》1968,24(10):1074-1074
Resumen La utilización del acetato de uranilo después del osmio durante la fijación, reduce la cantidad de fosfolípidos extraídos durante la deshidratación de los tejidos, lo que demuestra sus propiedades de fijador químico. 相似文献
143.
A. da Costa e Silva Z. P. Albuquerque 《Cellular and molecular life sciences : CMLS》1978,34(11):1465-1466
Summary A significant diminution in liver arginase activity of chronic renal failure uremic rats is described, thus implying that the experimental finding of an increased urea production is not due to a depressed arginase activity.This work was supported by the Conselho Nacional de Desenvolvimento Cientifico e Tecnologico do Brasil's Grants. —Acknowledgments. We are indebted to Mr D'Arrochela Lobo for technical assistance, Mr Celso Chiarin for the statistical review and Dr C.E. Tosta and Dr Linda Caldas for helpful advice. 相似文献
144.
M. Svartman E. J. Cardoso de Almeida 《Cellular and molecular life sciences : CMLS》1993,49(8):718-720
Cytogenetical data, including G-, C-bands and NORs distribution ofOxymycterus sp (2n=54; FN=64) captured in Distrito Federal, state of Goiás, Central Brazil are presented. Our results are compared to the karyotype information already available on this genus. 相似文献
145.
M. Queiroz da Cruz H. M. Bräscher J. R. Vargens A. Oliveira-Lima 《Cellular and molecular life sciences : CMLS》1991,47(1):89-92
Summary Viable metacyclic forms ofT. cruzi, Y strain, treated with an adequate dose of actinomycin D (50 g Act-D/ml/107 parasites/ml for 72 h at 28° C) showed the following properties: 1) they lost their ability to replicate in culture medium, in blood and in tissues of normal mice and were no longer able to incorporate tritiated thymidine; 2) they could no penetrate into Vero cells and could not replicate inside normal macrophages; 3) they retained their immunogenicity and the ability to protect mice against a virulent infection; 4) they did not induce histological lesions as described in chronic experimental Chagas' disease. 相似文献
146.
Bond J Roberts E Springell K Lizarraga SB Lizarraga S Scott S Higgins J Hampshire DJ Morrison EE Leal GF Silva EO Costa SM Baralle D Raponi M Karbani G Rashid Y Jafri H Bennett C Corry P Walsh CA Woods CG 《Nature genetics》2005,37(4):353-355
Autosomal recessive primary microcephaly is a potential model in which to research genes involved in human brain growth. We show that two forms of the disorder result from homozygous mutations in the genes CDK5RAP2 and CENPJ. We found neuroepithelial expression of the genes during prenatal neurogenesis and protein localization to the spindle poles of mitotic cells, suggesting that a centrosomal mechanism controls neuron number in the developing mammalian brain. 相似文献
147.
H. P. Lorez M. da Prada A. Pletscher 《Cellular and molecular life sciences : CMLS》1975,31(5):593-595
Zusammenfassung Nach Behandlung von Blutplättchen mit Mepacrin, Acridin-Orange und Daunomycin, die sich selektiv in den 5-Hydroxytryptamin- (5HT)-Speicher-organellen anreichern, werden letztere im Fluoreszenzmikroskop sichtbar. Unter violett-blauer Bestrahlung zeigen die einzelnen Plättchen mehrere sukzessive, blitzartige Zunahmen der Fluoreszenz-Intensität, wobei sie während einiger Sekunden vollständig ausgeleuchtet erscheinen. Die Blitze sind wahrscheinlich durch Freisetzung der fluoreszierenden Stoffe aus je einer 5HT-Speicherorganelle bedingt.
Acknowledgment. We thank DrsH. R. Baumgartner andH. Steffen, Research Department, F. Hoffmann-La Roche & Co. Ltd, Basel, for advice in performing and interpreting the experiments. 相似文献
Acknowledgment. We thank DrsH. R. Baumgartner andH. Steffen, Research Department, F. Hoffmann-La Roche & Co. Ltd, Basel, for advice in performing and interpreting the experiments. 相似文献
148.
Résumé Des rats ont été traités avec de la chlorpromazine et ont reçu en suite une seule injection de35S-méthionine. Des radioautographies des coupes histologiques ont montré que la chlorpromazine a un effect inhibitoire dans la synthèse de la protéine nucléaire et cytoplasmatique. Les cellules qui ont une grande vitesse de synthèse protéique sont les plus affectées.
This investigation was supported by grants from the Rockefeller Foundation and Conselho Nacional de Pesquisas.
The authors wish to acknowledge the help of Prof. L. C. U.Junqueira for criticism and encouragement, and MissEdna Freymüller for her skilled technical assistance. 相似文献
This investigation was supported by grants from the Rockefeller Foundation and Conselho Nacional de Pesquisas.
The authors wish to acknowledge the help of Prof. L. C. U.Junqueira for criticism and encouragement, and MissEdna Freymüller for her skilled technical assistance. 相似文献
149.
R. Rosa W. Silva G. Escalona de Motta A. D. Rodríguez J. J. Morales M. Ortiz 《Cellular and molecular life sciences : CMLS》1992,48(9):885-887
In a search for potential target sites for C11N5 compounds obtained from marine sponges of the genusAgelas we evaluated their interaction with muscarinic acetylcholine receptors from rat brain membranes. In competition experiments with3H-QNB these compounds displayed the following rank order of potency: sceptrin>oroidindibromosceptrinclathrodin. Sceptrin (50 M) was shown to be a competitive inhibitor of3H-QNB binding as revealed by Scatchard analysis. The results demonstrate the ability of these compounds to interact with multiple target molecules in the micromolar range. 相似文献
150.
Anjana Silva Ben Cristofori-Armstrong Lachlan D. Rash Wayne C. Hodgson Geoffrey K. Isbister 《Cellular and molecular life sciences : CMLS》2018,75(23):4465-4478
Snake venom α-neurotoxins potently inhibit rodent nicotinic acetylcholine receptors (nAChRs), but their activity on human receptors and their role in human paralysis from snakebite remain unclear. We demonstrate that two short-chain α-neurotoxins (SαNTx) functionally inhibit human muscle-type nAChR, but are markedly more reversible than against rat receptors. In contrast, two long-chain α-neurotoxins (LαNTx) show no species differences in potency or reversibility. Mutant studies identified two key residues accounting for this. Proteomic and clinical data suggest that paralysis in human snakebites is not associated with SαNTx, but with LαNTx, such as in cobras. Neuromuscular blockade produced by both subclasses of α-neurotoxins was reversed by antivenom in rat nerve–muscle preparations, supporting its effectiveness in human post-synaptic paralysis. 相似文献