A genome-wide association study in Han Chinese identifies new susceptibility loci for ankylosing spondylitis

To identify susceptibility loci for ankylosing spondylitis, we performed a two-stage genome-wide association study in Han Chinese. In the discovery stage, we analyzed 1,356,350 autosomal SNPs in 1,837 individuals with ankylosing spondylitis and 4,231 controls; in the validation stage, we analyzed 30 suggestive SNPs in an additional 2,100 affected individuals and 3,496 controls. We identified two new susceptibility loci between EDIL3 and HAPLN1 at 5q14.3 (rs4552569; P = 8.77 × 10(-10)) and within ANO6 at 12q12 (rs17095830; P = 1.63 × 10(-8)). We also confirmed previously reported associations in Europeans within the major histocompatibility complex (MHC) region (top SNP, rs13202464; P < 5 × 10(-324)) and at 2p15 (rs10865331; P = 1.98 × 10(-8)). We show that rs13202464 within the MHC region mainly represents the risk effect of HLA-B*27 variants (including HLA-B*2704, HLA-B*2705 and HLA-B*2715) in Chinese. The two newly discovered loci implicate genes related to bone formation and cartilage development, suggesting their potential involvement in the etiology of ankylosing spondylitis.     

Molten-salt synthesis of tungsten oxide nanotubes： Morphological and gas sensitivity

A very simple molten-salt method was used to synthesize WO3 nanotubes at moderate temperature （600 ）. The outer and inner diameters of the WO3 nanotubes were about 100 nm and 30 nm,with a length of dozens of micrometers. TEM and XRD analyses showed that the WO3 nanotubes were single crystal, and had monoclinic structure with the axes preferentially aligned along the [011] direction. The photoluminescence and the gas sensitivity of the nanotubes had been tested, showing that the products very well responded to acetone at 340℃.     

Best tracking performance for integrator and dead time plant

The optimal tracking performance for integrator and dead time plant in the case where plant uncertainty and control energy constraints axe to be considered jointly is inrestigated.Firstly,an average cost function of the tracking error and the plant input energy over a class of stochastic model errors are defined.Then,we obtain an internal model controller design method that minimizes the average performance and further studies optimal tracking performance for integrator and dead time plant in the simultaneous presence of plant uncertainty and control energy constraint.The results can be used to evaluate optimal tracking performance and control energy in practical designs.     

Peritectic solidification under high undercooling conditions

The solidification characteristics of highly undercooled Cu-7.77%Co peritectic alloy has been examined by glass fluxing technique. The obtained undercoolings vary from 93 to 203 K(0.14 TL). It is found that the α(Co) phase always nucleates and grows preferentially, which is followed by peritectic transformation. This means that the peritectic phase cannot form directly, even though the alloy melt is undercooled to a temperature far below its peritectic point. The maximum recalescence temperature measured experimentally decreases as undercooling increases , which is lower than the thermodynamic calculation result owing to the actual non-adia-batic nature of recalescence process. The dendritic fragmentation of primary α(Co) phase induced by high undercooling is found to enhance the completion of peritectic transformation. In addition, the LKT/BCT dendrite growth model is modified in order to make it applicable to those binary alloy systems with seriously curved liquidus and solidus lines. The dendrite growth velocities of primary α(Co) phase are subsequently calculated as a function of undercooling on the basis of this model.     

On the human resources management and development of construction enterprises

人力资源是21世纪市场经济中最重要的竞争力,而建筑施工企业的人力资源仍存在许多问题,必将制约该行业的发展.文章从人力资源管理与开发的理论出发,阐述了建筑施工业中人力资源的现状,分析了现状背后的原因,并提出了相应的对策建议.     

On the Differences in Single- walled Carbon Nanotubes and Multi- walled Carbon Nanotubes

碳纳米管作为最重要的纳米材料之一,其研究越来越得到人们的重视.文章主要综述了单壁碳纳米管和多壁碳纳米管的差异.     

The control of PLC in ash handing system in second - phase project of hejin power plant

文章根据河津发电厂二期2x300MW机组除灰系统的控制性能要求,采用“上位机+ PLC”的方式实现了对除灰系统的集中控制.系统设计具有抗干扰能力强,稳定性好,使用寿命长,扩展方便等优点.     

Climatic Characteristics and Trend Research of Fogs in Lin - fen from 1974 to 2009

利用临汾所辖17个站1974-2009年的观测资料,采用相关分析、趋势分析等方法,分析了雾的时空特征和长期变化趋势.结果发现:临汾市年平均雾日数为10.95 d,中间盆地的雾日数多大于周围山区和丘陵地区;秋季是雾的多发季节,地理分布差异最大;10月雾发生的频率最高;雾日数在1982年以前是偏少期,雾日最少的年份是2008年,雾日最多的年份是2006;临汾市雾日有一定变化趋势,西山永和、大宁、吉县等站呈明显下降趋势,而襄汾、临汾呈明显上升趋势,其余站点变化不大.     

螺旋手性SWBNNT尺寸对Lys分子手性转变反应限域的影响

用量子力学与分子力学组合的ONIOM方法, 研究两种构象的赖氨酸(Lys)分子限域在螺旋手性单壁氮化硼纳米管(SWBNNT)内的手性转变机理. 结果表明： 限域 在小管径螺旋手性SWBNNT的Lys分子骨架形变明显; 当两种构象的Lys分子限域在SWBNNT(6,4)时, 旋光异构反应的表观能垒分别为17590,23044 kJ/mol, 旋光异构反应决速步骤的内禀能垒分别为21140,23044 kJ/mol, 来源于质子从手性C向氨基N迁移的过渡态, 比裸反应的决速步骤能垒(252.60 kJ/mol) 低. 即螺旋手性SWBNNT的管径越小, 限域催化作用越明显, 限域在SWCNT(6,4)内具有氨基与羧基间单氢键的Lys分子先旋光异构.