图像边缘检测经典算法研究综述

边缘检测是图像处理领域中的基本课题.本文就图像边缘检测的具体内容及几种传统的图像边缘检测方法进行了综述.分析了各种边缘检测算子的特点,并对它们的检测效果进行了分类比较.提出了该研究领域还存在的问题及发展趋势.     

关于提高高校图书馆员素质和自主学习的思考

阐述了高校图书馆员的现状,探讨了提高图书馆员素质的重要性和必要性,从自主学习的角度论述了高校馆员素质提高的有效途径,并阐述了馆员素质提高与自主学习之间的密切关系.     

12CaO·7Al2O3型精炼合成渣物性与脱硫试验

对近两年从国外发展起来的新型精炼合成渣 12 Ca O· 7Al2 O3的烧成工艺、物性和脱硫能力进行了试验研究。结果表明 ,该渣系原料来源广泛 ,成本较低 ;以 12 Ca O· 7Al2 O3为低熔点相 ,具有较低的熔化温度 ,在精炼温度下具有较好的流动性 ;由于具有很高的碱度和 Al2 O3含量 ,因而具有较强的脱硫能力和吸附铝脱氧产物的能力 ,并且在精炼过程中还可配加大量石灰 ,进一步提高其脱硫能力 ,尤其适用于铝脱氧钢     

一部全面揭示唐代西南地区经济发展的学术著作——评卢华语等著《唐代西南经济研究》

由科学出版社出版的卢华语等著《唐代西南经济研究》,突破地方行政区划的局限,以区域史架构,全面、系统地论述唐代整个西南地区经济发展的全貌、揭示该地经济发展的多样性、差异性及兼容并包的地域特色,并对比了西南与江南二地在唐时的经济发展,在研究方法上采用宏观与微观、定性与定量、文史互证等多种方法,资料翔实。进一步拓展、挖掘了经济史研究的空间和深度。     

Retromer复合体通过吞噬受体CED-1调控凋亡细胞的清除

程序性细胞死亡（细胞凋亡）是一个对生物体的发育、组织的动态稳定至关重要的生物学过程。细胞凋亡的发生过程如下：在决定要凋亡的细胞内,一些死亡基因被启动,细胞被杀死,这称为凋亡的执行过程。随后,凋亡细胞被吞噬细胞识别并内吞;最终,凋亡细胞在吞噬细胞内被完全降解。凋亡细胞的吞噬和降解是细胞凋亡程序的重要环节,凋亡细胞的清除障碍会引起炎症疾病和免疫紊乱。在秀丽隐杆线虫中,吞噬受体CED-1对于吞噬细胞识别凋亡细胞起着关键作用。本研究发现细胞内的蛋白分选复合体retromer可以通过调控CED-1在细胞膜与细胞质之间的循环来参与凋亡细胞的清除过程。Retromer会被招募到吞噬小体的表面,介导CED-1从吞噬小体到细胞膜的回收过程。当retromer丧失功能时,CED-1会被运送到溶酶体降解,CED-1的这种减少造成了凋亡细胞的清除障碍。我们的工作揭示了retromer复合体参与凋亡细胞清除的这一新功能,并发现了吞噬受体的一种新的调控机制。     

The Theoretical and Experimental Analysis of the Maximal Information Coefficient Approximate Algorithm

In the era of big data, correlation analysis is significant because it can quickly detect the correlation between factors. And then, it has been received much attention. Due to the good properties of generality and equitability of the maximal information coefficient(MIC), MIC is a hotspot in the research of correlation analysis. However, if the original approximate algorithm of MIC is directly applied into mining correlations in big data, the computation time is very long. Then the theoretical time complexity of the original approximate algorithm is analyzed in depth and the time complexity is n2.4 when parameters are default. And the experiments show that the large number of candidate partitions of random relationships results in long computation time. The analysis is a good preparation for the next step work of designing new fast algorithms.     

A genome-wide scan identifies mutations in the gene encoding phosphodiesterase 11A4 (PDE11A) in individuals with adrenocortical hyperplasia

Phosphodiesterases (PDEs) regulate cyclic nucleotide levels. Increased cyclic AMP (cAMP) signaling has been associated with PRKAR1A or GNAS mutations and leads to adrenocortical tumors and Cushing syndrome. We investigated the genetic source of Cushing syndrome in individuals with adrenocortical hyperplasia that was not caused by known defects. We performed genome-wide SNP genotyping, including the adrenocortical tumor DNA. The region with the highest probability to harbor a susceptibility gene by loss of heterozygosity (LOH) and other analyses was 2q31-2q35. We identified mutations disrupting the expression of the PDE11A isoform-4 gene (PDE11A) in three kindreds. Tumor tissues showed 2q31-2q35 LOH, decreased protein expression and high cyclic nucleotide levels and cAMP-responsive element binding protein (CREB) phosphorylation. PDE11A codes for a dual-specificity PDE that is expressed in adrenal cortex and is partially inhibited by tadalafil and other PDE inhibitors; its germline inactivation is associated with adrenocortical hyperplasia, suggesting another means by which dysregulation of cAMP signaling causes endocrine tumors.     

Differentiated cells are more efficient than adult stem cells for cloning by somatic cell nuclear transfer

Since the creation of Dolly via somatic cell nuclear transfer (SCNT), more than a dozen species of mammals have been cloned using this technology. One hypothesis for the limited success of cloning via SCNT (1%-5%) is that the clones are likely to be derived from adult stem cells. Support for this hypothesis comes from the findings that the reproductive cloning efficiency for embryonic stem cells is five to ten times higher than that for somatic cells as donors and that cloned pups cannot be produced directly from cloned embryos derived from differentiated B and T cells or neuronal cells. The question remains as to whether SCNT-derived animal clones can be derived from truly differentiated somatic cells. We tested this hypothesis with mouse hematopoietic cells at different differentiation stages: hematopoietic stem cells, progenitor cells and granulocytes. We found that cloning efficiency increases over the differentiation hierarchy, and terminally differentiated postmitotic granulocytes yield cloned pups with the greatest cloning efficiency.     

油气弹簧系统阻尼特性的仿真分析

本文主要对油气弹簧系统的阻尼特性进行分析.建立油气弹簧缸的物理模型,计算阻尼力和阻尼系数建立数学模型,并利用Matlab/Simulink系统对油气弹簧阻尼特性进行仿真.     

Instruments of Music,Instruments of Science: Hermann von Helmholtz's Musical Practices,his Classicism,and his Beethoven Sonata

The young Hermann Helmholtz, in an 1838 letter home, declared that he always appreciated music much more when he played it for himself. Though a frequent concert-goer, and celebrated for his highly influential 1863 work on the physiological basis of music theory, Die Lehre von den Tonempfindungen, it is likely that Helmholtz's enduring engagement with music began with his initial, personal experience of playing music for himself. I develop this idea, shifting the discussion of Helmholtz's work on sound sensation back to its origins, and examine the role of his material interaction with musical instruments and music itself. In his sound sensation studies, Helmholtz understood sound as an external, physical object. But Helmholtz also conceived of sound in musical terms. Further, Helmholtz's particular musical tastes as well as his deeply personal interaction with musical instruments allowed him to reconcile his conception of sound as physical object with his conception of sound as music. Helmholtz's physiological theory of sound sensation was both the product of and constitutive of how he heard and created sound. I argue that Helmholtz himself was the embodied reconciliation of his physiological theory of sound sensation and his belief that musical aesthetics were historically and culturally contingent.