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Resumen El efecto de estímulos condicionantes sobre el potencial evocado del área prepiriforme fué estudiado en gatos. La estimulación del bulbo olfatorio y de la corteza prepiriforme contralateral provocan inhibiciones de larga duración (> de 100 mseg); estas pertenecen al tipo presináptico a juzgar por la depolarización aferente primaria (DAP) de los terminales axónicos y los efectos desinhibitorios de la picrotoxina. 相似文献
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Hall N Pain A Berriman M Churcher C Harris B Harris D Mungall K Bowman S Atkin R Baker S Barron A Brooks K Buckee CO Burrows C Cherevach I Chillingworth C Chillingworth T Christodoulou Z Clark L Clark R Corton C Cronin A Davies R Davis P Dear P Dearden F Doggett J Feltwell T Goble A Goodhead I Gwilliam R Hamlin N Hance Z Harper D Hauser H Hornsby T Holroyd S Horrocks P Humphray S Jagels K James KD Johnson D Kerhornou A Knights A Konfortov B Kyes S Larke N Lawson D Lennard N Line A Maddison M 《Nature》2002,419(6906):527-531
Since the sequencing of the first two chromosomes of the malaria parasite, Plasmodium falciparum, there has been a concerted effort to sequence and assemble the entire genome of this organism. Here we report the sequence of chromosomes 1, 3-9 and 13 of P. falciparum clone 3D7--these chromosomes account for approximately 55% of the total genome. We describe the methods used to map, sequence and annotate these chromosomes. By comparing our assemblies with the optical map, we indicate the completeness of the resulting sequence. During annotation, we assign Gene Ontology terms to the predicted gene products, and observe clustering of some malaria-specific terms to specific chromosomes. We identify a highly conserved sequence element found in the intergenic region of internal var genes that is not associated with their telomeric counterparts. 相似文献
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J. P. Horwitz L. Horn A. V. Loud S. C. Brooks 《Cellular and molecular life sciences : CMLS》1962,18(9):414-416
Zusammenfassung Die Inkubation von 16-C14-Oestron und 4-C14-Oestradiol--acetat in Puffer (pH 7.4) bei Gegenwart von Rattenleber ergibt elektrophoretisch zwei deutliche radioaktive Bänder. Das erste Band entsteht im Albuminbereich und stimmt mit den früheren Beobachtungen vonSzego undRoberts
2 überein. Das zweite, früher nicht beschriebene Band entsteht deutlich ausserhalb des Albuminbereiches. Beide Kurvengipfel werden mit wenig homogenisierter Rattenleber, die möglichst frei von Mikrosomen ist, gewonnen. Der zweite Gipfelpunkt wird in diesem Fall der obenauf schwimmenden Phase zugeschrieben. 相似文献
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Theologis A Ecker JR Palm CJ Federspiel NA Kaul S White O Alonso J Altafi H Araujo R Bowman CL Brooks SY Buehler E Chan A Chao Q Chen H Cheuk RF Chin CW Chung MK Conn L Conway AB Conway AR Creasy TH Dewar K Dunn P Etgu P Feldblyum TV Feng J Fong B Fujii CY Gill JE Goldsmith AD Haas B Hansen NF Hughes B Huizar L Hunter JL Jenkins J Johnson-Hopson C Khan S Khaykin E Kim CJ Koo HL Kremenetskaia I Kurtz DB Kwan A Lam B Langin-Hooper S Lee A Lee JM Lenz CA Li JH Li Y Lin X Liu SX Liu ZA Luros JS 《Nature》2000,408(6814):816-820
The genome of the flowering plant Arabidopsis thaliana has five chromosomes. Here we report the sequence of the largest, chromosome 1, in two contigs of around 14.2 and 14.6 megabases. The contigs extend from the telomeres to the centromeric borders, regions rich in transposons, retrotransposons and repetitive elements such as the 180-base-pair repeat. The chromosome represents 25% of the genome and contains about 6,850 open reading frames, 236 transfer RNAs (tRNAs) and 12 small nuclear RNAs. There are two clusters of tRNA genes at different places on the chromosome. One consists of 27 tRNA(Pro) genes and the other contains 27 tandem repeats of tRNA(Tyr)-tRNA(Tyr)-tRNA(Ser) genes. Chromosome 1 contains about 300 gene families with clustered duplications. There are also many repeat elements, representing 8% of the sequence. 相似文献
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Marin MC Jost CA Brooks LA Irwin MS O'Nions J Tidy JA James N McGregor JM Harwood CA Yulug IG Vousden KH Allday MJ Gusterson B Ikawa S Hinds PW Crook T Kaelin WG 《Nature genetics》2000,25(1):47-54
The p73 protein, a homologue of the tumour-suppressor protein p53, can activate p53-responsive promoters and induce apoptosis in p53-deficient cells. Here we report that some tumour-derived p53 mutants can bind to and inactivate p73. The binding of such mutants is influenced by whether TP53 (encoding p53) codon 72, by virtue of a common polymorphism in the human population, encodes Arg or Pro. The ability of mutant p53 to bind p73, neutralize p73-induced apoptosis and transform cells in cooperation with EJ-Ras was enhanced when codon 72 encoded Arg. We found that the Arg-containing allele was preferentially mutated and retained in squamous cell tumours arising in Arg/Pro germline heterozygotes. Thus, inactivation of p53 family members may contribute to the biological properties of a subset of p53 mutants, and a polymorphic residue within p53 affects mutant behaviour. 相似文献